basic science

Question 1

Stratum Spinosum __made de novo

Answer 1

– K1 and 10

Question 3

not made de novo in Stratum Spinosum

Answer 3

– K5 and 14

Question 3

K1 and 10 downregulated in

Answer 3

psoriasis

Question 4

– K6 and 16 upregulated in

Answer 4

psoriasis

Question 5

Desmocollin (Dsc) 1 (115kd and 105kd) and 2

Answer 5

Subcorneal pustular derm

Question 7

LABD Ag (NC 16 and col) (97/120kd)

Answer 7

Linear IgA

Question 8

Desmoglein (Dsg) 3 (130kd)

Answer 8

ntraepidermal neutrophilic

IgA dermatosis

Question 8

JEB

Answer 8

lam 5

Question 9

Intergrin a6b4

Answer 9

JEB with pyloric atresia

Question 10

Dsg 3 mostly, Dsg 1

Answer 10

Pemphigus vulgaris

Question 11

Pemphigus foliaceus

Answer 11

Dsg 1 (160kd)

Question 12

BPAg1 (230kd), Plectin

Desmoplakin (250kd),Envoplakin (210kd), Periplakin (190kd),(500kd), Dsg 1 and 3

Answer 12

Paraneoplastic Pemphigus

Question 13

cells that arrive first

Answer 13

• Neutrophils (greater in number) and monocytes

Question 14

Wound Healing

• Platelets (first response) release mediators like

Answer 14

ADP

Question 15

• Granulation

Fibronectin –>col III →

Answer 15

col I

Question 16

– 4 days after injury

Answer 16

• Granulation

Question 17

• Wound contraction

– are important (contain actin)

Answer 17

Myofibroblasts

Question 18

– Hours after injury

Answer 18

• Epithelialization

Question 19

___ are required for healing perform

– Debridement and secretion

Answer 19

• Macrophages

Question 20

k ___in all layers of migrating epidermis (normally in basal only)

Answer 20

– K5 and 14

– K6 and 16

Question 21

col V, fibrin and fibronectin form

Answer 21

provisional matrix

Question 22

___ receptors guide the path

Answer 22

– Integrin

Question 23

• First follicles on face at gestation

Answer 23

nine weeks

Question 24

• Hair-Remaining develop at

Answer 24

four to five months

Question 25

• Adults cannot generate new follicles T/F

Answer 25

T

Question 26

Most mitotic activity below this line

Answer 26

– Critical line of Auber | • Widest diameter of the bulb

Question 27

maintains the integrity of hair

Answer 27

– Cuticle

Question 28

bulk of keratins

Answer 28

– Cortex contains

Question 29

broken during hair styling

Answer 29

– Disulfide bonds are

Question 30

– Outer root sheath (ORS) | followed by

Answer 30

(IRS) then shaft

Question 31

(two to six years on scalp)

Answer 31

– Anagen

Question 32

– Inner root sheath from peripheral inward

Answer 32

* Henle’s | * Huxley’s

Question 33

• Cuticle | – Shaft from peripheral inward

Answer 33

* Cuticle * Cortex * Medulla

Question 34

Five substages (proanagen)

Answer 34

below the skin and

Question 35

___ is defined by | emergence above the skin

Answer 35

sixth substage (metanagen)

Question 36

85% of al hairs

Answer 36

anagen

Question 37

• Types of hair | –< 1 cm in length

Answer 37

Vellus—

Question 38

—1 cm

Answer 38

– Indeterminate

Question 39

—>1 cm

Answer 39

– Terminal

Question 40

– Reduced pigment

Answer 40

—gray

Question 41

– Loss of function mutation → shift from eumelanin to pheomelanin

Answer 41

Melanocortin-1 receptor (MC1R) is associated with red hair

Question 42

two to three weeks on scalp

Answer 42

– Catagen

Question 43

* Thinning and loss of pigment | * Matrix cells terminally differentiate

Answer 43

– Catagen

Question 44

• 1% of all hairs

Answer 44

– Catagen

Question 45

(two to three month on scalp)

Answer 45

– Telogen

Question 46

iClub-shaped har | • is shed

Answer 46

– Telogen

Question 47

• IRS absent

Answer 47

– Telogen

Question 48

• 14% of all hairs

Answer 48

– Telogen

Question 49

– Hair grows

Answer 49

0.4 mm/day

Question 50

– Melanin only formed when in phase

Answer 50

anagen

Question 51

• G protein-coupled receptor - 7 transmembrane domains receptor

Answer 51

Melanocortin-1 receptor (MC1R)

Question 52

• G protein-coupled receptor - 7 transmembrane domains receptor

Answer 52

Melanocortin-1 receptor (MC1R)

Question 53

western blot identifies

Answer 53

Protein

Question 54

northern blot identifies

Answer 54

RNA

Question 55

southern blot identifies

Answer 55

DNA.

Question 56

keratins expressed in the nail bed.

Answer 56

Keratins 6b & 17

Question 57

K6a/16 is expressed in

Answer 57

outer root sheath and in hyperproliferative keratinocytes,

Question 58

k4/13 expressed in

Answer 58

mucosal epithelium.

Question 59

k 1/9 in

Answer 59

palmoplantar suprabasalar keratinocytes,

Question 60

k2e/10

Answer 60

upper spinous and granular cell layers,

Question 61

markers for hyperproliferative keratinocytes. They are found in skin disease such as psoriasis, warts, actinic keratoses, and SCC's.

Answer 61

K16 and K6