Basic Science Concepts

Question 1

Receptor: Muscarinic
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 1

Muscarinic
Ach

incr’ SLUDD
Pilocarpine, bethamechol (aka colinergic agonists)

decr’ SLUDD
Atropine, oxybutynin

Question 2

Receptor: Nicotinic
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 2

Nicotinic
Ach

incr’ HR, BP
Nicotine

Neuromuscular blockade
Rocuronium

Question 3

Receptor: Alpha-1 (mainly peripheral)
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 3

Alpha-1 (mainly peripheral)
Epi, NE

Smooth muscle vasoconstriction, incr’ BP
Phenylephrine, dose-dependent dopamine

Smooth muscle vasodilation, decr’ BP
Alpha-1 blockers (doxazosin, phentolamine, carvedilol)

Question 4

Receptor: Alpha-2 (mainly brain, central)
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 4

Alpha-2 (mainly brain, central)
Epi, NE

Decr’ release of NE & Epi in the brain
decr’ HR, BP
Clonidine, brimonidine (opth for glaucoma)

incr’ HR, BP
Ergot alkaloids, yohimbine

Question 5

Receptor: Beta-1 (mainly heart)
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 5

Beta-1 (mainly heart)
Epi, NE

incr’ myocardial contractility, CO, HR
Dobutamine, isoproterenol, dose-dependent dopamine

decr’ CO, HR
Beta-1 selective blockers (metoprolol) and non-selective BB (propranolol, carvedilol)

Question 6

Receptor: Beta-2 (mainly lungs)
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 6

Beta-2 (mainly lungs)
Epi

Bronchodilation
Albuterol, terbutaline, isoproterenol

Bronchoconstriction
Non-selective BB (propranolol, carvedilol)

Question 7

Receptor: Dopamine
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 7

Dopamine
Dopamine

Many including renal, cardiac and CNS effects
Levodopa, pramipexole

Many including renal, cardiac and CNS effects
FGA (haloperidol), metoclopramide

Question 8

Receptor: Serotonin
Endo-substrate

Agonist action
Agonist drug

Antagonist action
Antagonist drug

Answer 8

Serotonin
Serotonin

Many, including platelets, GI and psychiatric effects
Triptans (sumatriptan)

Many, including platelets, GI and psychiatric effects
Ondansetron, SGA (quetiapine)