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Flashcards in Basics Deck (12)
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1

Types of Neurones

1. Principal cells/ Interneurons
2. Golgi Type 1
3. Golgi Type 2

2

Primary types of Glial cells

1. Astrocytes
2. Oligodendrocytes
3. Tanycytes
-> Microglia

3

Roles of astrocytes

1. Structural
2. Glycogen fuel reserve
3. BBB
4. Metabolic support
5. Regulation of ion conc.

4

Ependyma

thin neuroectodermal lining of the ventricular system of the brain
-> 1/4 types of ependymal cells
-> CSF production

5

Tanycyte

Specialed ependyma cell found in 3rd ventricle + floor of 4th to hypothalamus

6

How do we categorise synapses?

Gray type 1 - asymmetric
Gray type 2 - symmetric

7

What are the output possible projections of the medium spiny neurone?

External Globus pallidus, internal globus pallidus/ primary substantia nigra

8

What are the inputs to the medium spiny neurone?

Cerebral cortex, thalamus, substantia nigra

9

Why type of cells are medium spiny neurones?

GABAergic inhibitory cell in the striatum

10

Primary phenotypes of MSNs

1. D1 direct pathway
2. D2 indirect pathway

11

Direct pathway MSNs...

excite ultimate basal ganglia output structure
- express: D1, A1 (adenosine), dynorphin peptides + substance P

12

Indirect pathway MSNs...

Inhibit output structure
- express: D2, A2A, DRD2-A2A heterotramers + enkephalin