basics patho Flashcards
which transport mechanism is first activated in cell automatically once cellular swelling occurs
na-k-atpase
Whorled phospholipid precipitate derived from damaged cell membrane; phagocytized or degraded into fatty acid
may lead t calcium soap formation
myelin figures
seen in necrosis
3 characteristics of nuclear change
karyolysis - basophilia of chromatin may fade or dissolve
pyknosis - nuclear shrinkage and increased basophilia
karyorrhexis - pyknotic nucleus goes fragmentation
architecture of dead tissue is preserved for a few days
localized area is called an infarct
coagulative necrosis
heart renal
digestion of dead cells, resulting in transformation of the tissue into a liquid viscous mass
liquefactive necrosis
brain
abscess
pleural effusion
coagulative necrosis involving multiple tissue planes usually applied to the limb
grangenois necrosis
architecture not preserve, cheese like (friable white appearance)
granuloma formation (to contain the infection)
caseation necrosis
ptb, syphillitic, coccidiomycosis, cryptococcosis, histoplasmosis
2 types of fat necrosis
enzymatic fat necrosis- saponification like acute pancreatitis
traumatic fat necrosis
what electrolyte abnormality occurs in acute pancreatitis as a result of saponification?
hypocalcemia
type of necrosis d/t complexes of antigen & antibody are deposited in the walls of arteries
like vasculitis
fibrinoid necrosis
cell size in necrosis is?
apoptosis?
necrosis- enlarge
apoptosis- reduced/shrink
cell membrane in necrosis is?
apoptosis?
necrosis- disrupted
apoptosis- intact
2 types of irreversible injury
necrosis - always pathologic
apoptosis
suicide bags of cells
lysosomes
first manifestation of reversible cell injury
cellular swelling
sublethal/hydropic changes
