Basics- Pharm

Question 1

Ibuprofen- type of drug?

Answer 1

Class 1 NSAID
- Competitive, reversible inhibitor that competes with arachidonic acid for COX active site
(better tolerated than aspirin and indomethacin, but shares the detrimental features of other NSAIDs)(better tolerated than aspirin and indomethacin, but shares the detrimental features of other NSAIDs)

Question 2

Naproxen- type of drug?

Answer 2

Class 1 NSAID
- Competitive, reversible inhibitor that competes with arachidonic acid for COX active site
(same as Ibuprofen)
(better tolerated than aspirin and indomethacin, but shares the detrimental features of other NSAIDs)

Question 3

COX-1 vs. COX-2?

Answer 3

Cox‐2: Produce prostaglandins mediating inflammation, fever & pain

COX-1: Produce prostaglandins important in GI & renal function

• Mucosa protection
• Platelet aggregation
• Renal blood flow

• Therefore, Cox‐2 specific inhibitors will reduce pain, fever, & inflammation without causing GI or renal injury

Question 4

Aspirin- MOA, therapeutic effects, & adverse effects?

Answer 4

MOA: Irreversibly acetylates COX-1 & 2
TEs: 
- Analgesic
- Antipyretic
- Anti-inflammatory
- Inhibits thrombosis (patients @ risk for MI)
AEs:
- GI irritation
- Increased bleeding time
- Prolongs gestation
- Inhibits renal function
- Induces asthma

Question 5

Acetaminophen

Answer 5

• Strong analgesic and antipyretic activity
• Very widely used nonopioid analgesic
• Very weak antiinflammatory activity
• Fewer side effects (in comparison w/ NSAIDs)
• Overdose can cause fatal liver damage - metabolite interacts with liver proteins

Question 6

Pheochromocytoma Tx:

Use _____ before removing tumor since high levels of released catecholamines will not be able to overcome blockage.

Answer 6

Phenoxybenzamine

Question 7

Sympathetic-blocker drug given to patients on MAO inhibitors who eat tyramine-containing foods?

Answer 7

Phentolamine