BCH202

Question 1

What is the only pathway taking place in all cells

Answer 1

Glycolysis

Question 2

What part of the cell does glycolysis take place in

Answer 2

Cytoplasm/ Cytosol

Question 3

GLUT4 transporter is present in

Answer 3

Muscles and adipose tissue

Question 4

The end product of citric acid cycle is ?

Answer 4

Three molecules of NADH and one molecule of FADH2

Question 4

What transporter is located in intestine and kidney

Answer 4

SGLUT transporter

Question 5

Another name for glycolysis is ?

Answer 5

Embden Meyerhof Pathway

Question 6

The only source of energy in erythrocytes is ?

Answer 6

Glycolysis

Question 7

Enolase is inhibited by ?

Answer 7

Fluoride .

Question 8

Lactate dehydrogenase has how many isoenzymes ?

Answer 8

5

Question 9

The end product of glycolysis in RBC is

Answer 9

Lactic acid

Question 10

Accumulation of lactic acid in muscle cells causes

Answer 10

Muscle cramps

Question 11

The end product of glycolysis in RBC is ?

Answer 11

Lactic acid

Question 12

Pyruvate is converted to Acetyl CoA by a process known as

Answer 12

Oxidative decarboxylation

Question 13

1 NADH molecule and 3 NADH molecule produces how many ATP molecules respectively

Answer 13

1 NADH - 2.5 ATP
3 NADH- 7.5 ATP

Question 14

What is an important precursor in fatty acid biosynthesis and cholesterol synthesis

Answer 14

Acetyl CoA

Question 15

How many coenzymes does pyruvate dehydrogenase complex have and what are they ?

Answer 15

5
1. Thiamine pyrophosphate (TPP)
2. Coenzyme A
3. NAD+
4. FAD
5. Lipoic acid or lipoamide

Question 16

How many apoenzymes does pyruvate dehydrogenase complex have and what are they

Answer 16

3
1. Pyruvate dehydrogenase
2. Dihydrolipoyl transacetylase
3. Dihydrolipoyl dehydrogenase

Question 17

The reaction of citric acid cycle takes place in ?

Answer 17

Mitochondrial matrix

Question 18

TCA cycle produces how many molecules of ATP?

Answer 18

10

Question 19

Who discovered citric acid cycle ?

Answer 19

Hans Krebs

Question 20

How many ATP molecules does FADH2 produce ?

Answer 20

1.5 ATP

Question 21

Which of the cycles is amphibolic and anaplerotic

Answer 21

TCA cycle

Question 22

How many hydrogen molecules does Urea have ?

Answer 22

2

Question 23

What determines the type of transporter used for a protein ?

Answer 23

The R- side chain

Question 24

Arsenate inhibits which of the glycolysis enzymes

Answer 24

Glyceraldehyde -3 - phosphate dehydrogenase

Question 25

How many ATP is consumed in Urea cycle

Answer 25

4

Question 26

To form Carbamoyl phosphate how many ATP is required?

Answer 26

2

Question 27

Which of the substrates in urea cycle can form proline

Answer 27

Ornithine

Question 28

The two processes in urea cycle consuming ATP are

Answer 28

Formation of arginosuccinate and carbamoyl phosphate

Question 29

How many carbamoyl phosphate synthase are present in human tissues

Answer 29

2

Question 30

The carbamoyl phosphate synthaseII is used in? And is a — enzyme

Answer 30

Used in pyrimidine nucleotide sequences . It is a cytosolic enzyme

Question 31

Carbamoyl phosphate synthase -I is a ?

Answer 31

Hepatic mitochondrial enzyme

Question 32

Muscles release ammonia in the form of — in a process known as —

Answer 32

Alanine Glucose - alanine cycle

Question 33

Which of the following substrates in the urea cycle is a precursor for polyamines

Answer 33

Ornithine

Question 34

What are the purely ketogenic amino acids?

Answer 34

Leucine and lysine

Question 35

Which amino acids are both glucogenic and ketogenic?

Answer 35

Isoleucine, phenylalanine, Tyrosine, Tryptophan

Question 36

What does it mean for an amino acid to be ketogenic?

Answer 36

It can be degraded to acetyl CoA and acetoacetyl COA which can form ketone bodies but not glucose

Question 37

What does it mean for an amino acid to be glucogenic?

Answer 37

It can be degraded into pyruvate, and other intermediate of TCA cycle (oxaloacetate, a- ketoglutarate, Succinyl - CoA, Fumarate) and can be converted back to glucose by gluconeogenesis

Question 38

Which amino acids does not undergo transamination ?

Answer 38

Lysine, threonine and proline

Question 39

Which amino acids does not undergo deamination

Answer 39

None

Question 40

What enzyme is deficient in OTC deficiency?

Answer 40

Ornithine transcarbamylase

Question 41

What are the gray tires of CPSI deficiency

Answer 41

Hyperammonemia, lethargy, poor feeding in new borns

Question 42

What are the features of CPSI deficiency?

Answer 42

Hyperammonemia, lethargy, vomiting in new borns

Question 42

Which urea cycle disorder presents with elevated orotic acid?

Answer 42

OTC deficiency or hyperamonnemia

Question 43

What are the features of CPSI deficiency?

Answer 43

Hyperammonemia, lethargy, vomiting in new borns

Question 44

What accumulates in arginosuccinic aciduria ?

Answer 44

Arginosuccinic acid/ argunosuccinate

Question 45

What accumulates in arginosuccinic aciduria ?

Answer 45

Arginosuccinic acid/ argunosuccinate

Question 46

What accumulates in arginosuccinic aciduria?

Answer 46

Arginosuccinic acid/ argunosuccinate

Question 47

What accumulates in arginosuccinic aciduria?

Answer 47

Arginosuccinic acid or argunosuccinate

Question 48

What disorder causes sweet- smelling urine ?

Answer 48

Maple Syrup Urine Disease

Question 49

What enzyme is deficient in phenylketonuria ( PKU) ?

Answer 49

Phenylalanine hydroxylase

Question 50

What is the hallmark of alkaptonuria ?

Answer 50

Black urine and dark pigmentation of cartilage

Question 51

What enzyme is deficient in phenylketonuria ( PKU)?

Answer 51

Phenylalanine hydroxylase

Question 52

What disorder is associated with high homocysteine and thrombosis?

Answer 52

Homocystinuria

Question 53

What class of uremia is due to kidney damage ?

Answer 53

Renal Uremia

Question 54

What is prerenal uremia caused by?

Answer 54

Reduced renal perfusion and high protein diet

Question 55

What causes post renal uremia

Answer 55

Urinary tract obstruction.

Question 56

Which disorder presents with liver failure and cabbage- like odor

Answer 56

Tyrosinemia type - I

Question 57

What amino acids accumulate in Maple Syrup Urine Disease?

Answer 57

Isoleucine, valine, leucine

Question 58

What urea cycle disorder causes high citrulline levels

Answer 58

Citrullinemia

Question 59

What amino acids accumulate in Maple Syrup Urine Disease ?

Answer 59

Isoleucine, valine, leucine

Question 60

What enzyme is deficient in arginemia?

Answer 60

Arginase

Question 61

Eicosanoids are considered to be a class of - fatty acids

Answer 61

20 carbon

Question 62

Eicosanoids are classified into three which are

Answer 62

Prostaglandins Leukotrienes Thromboxanes

Question 63

Prostaglandins are derived from

Answer 63

Arachidonic acid

Question 64

Prostaglandin are said to be derived from the cyclic fatty acid

Answer 64

Prostanoic acid

Question 65

Prostaglandin have how many cyclopentane rings and how many aliphatic side chain

Answer 65

5 cyclopentane rings and 2 aliphatic side chains

Question 66

What are the primary processes in inflammation

Answer 66

Vasodilation, increased vascular permeability, chemotaxis, phagocytosis, release of inflammatory mediators and tissue repair for regeneration

Question 67

NSAIDS actions include

Answer 67

Reduce pain, decrease fever, prevent blood clot And in higher doses decrease inflammation

Question 68

Is paracetamol an NSAID? And why your choice of answer

Answer 68

No, it inhibits cox 2 in the CNS

Question 69

Leukotrienes is produced where ?

Answer 69

In neutrophils

Question 70

Leukotrienes has

Answer 70

No cyclic rings and 4 double bonds

Question 71

Cyclooxygenase is also known as

Answer 71

Prostaglandin endoperoxide synthetase