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BCR Flashcards

1
Q

Ce det > 70% din toate cazurile de BCR

A
  1. DZ
  2. HTA
  3. Ateroscleroza
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2
Q

De ce depinde rata de declin a functiei renale

A
  1. Nefropatia de baza

2. Controlul HTA

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3
Q

Efecte angiotensina II

A
  1. Moduleaza pres capilara intragl si RFG
  2. Vasoconstrictia arteriolelor postgl
  3. Cresterea pres hidrostatice gl
  4. Cresterea fractiei de filtrare
  5. Stim prod de TGF beta si PAI-1
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4
Q

Prognosticul BCR se coreleaza cu

A
  1. HTA
  2. Proteinurie
  3. Gradul de lezare a interstitiului
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5
Q

Mecanismele anemiei normocrome normocitare

A
  1. Deficit de eritropoietina
  2. Pierderi de sange
  3. Afectare MO
  4. Deficit vit si minerale
  5. Distrugere crescuta eritrocite
  6. IECA
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6
Q

Agenti stimulatori ai eritropoiezei - ex, RA

A
  1. Epoetina - alfa, beta; Darbepoetina alfa

2. RA: HTA, encefalopatie, orbire corticala tranzitorie

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7
Q

Efecte FGF23

A
  1. Fosfaturie
  2. Inhiba 1alfa hidroxilaza renala
  3. Scade capacitatea vit D de a abs fosfat intestinal
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8
Q

Cel mai puternic predictor al mortalitatii in BCR

A

Nivelul crescut de FGF23

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9
Q

Modif biochimice caract hiperparatiroidismului sec

A
  1. Hipocalcemie
  2. Hiperfosfatemie
  3. Creste PTH
  4. Creste FA
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10
Q

Trat in reducerea fosforului si limitarea incarcaturii excesive cu Ca

A
  1. Restrictie dietetica
  2. Chelatori int de fosfor
  3. Chelatori int de fosfor cu Al
  4. Tenapanor
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11
Q

Chelatori int de fosfor

A

Carbonat Sevelamer, carbonat de lantan, carbonat si acetat de Ca

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12
Q

Trat in controlul PTH si obt unui nivel normal al Ca seric

A
  1. Calcitrol (1,25-(OH2)D3)
    Analogi vit D3 - alfacalcidol
    Noii metaboliti ai vit D3 - oxacalcitrol, paricalcitol, doxercalciferol
  2. Agenti calcimimetici - cinacalcet, etelcalcetid
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13
Q

Factori de risc in boala cardiovasculara

A
  1. HTA
  2. DZ
  3. Dislipidemia
  4. Fumat
  5. Barbati
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14
Q

Factori de risc in aparitia calcificarilor

A
  1. calciu x fosfor crescut
  2. hiperparatiroidism
  3. uremie
  4. inflamatie
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15
Q

Biopsia in FSN

A

Proliferarea fibrocitelor din derm cu depunere excesiva de colagen

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16
Q

Medicamente nefrotoxice

A
  1. tetracicline (exceptie doxi)
  2. gentamicina
  3. AINS
  4. spironolactona, amilorid
17
Q

Debitul sangvin necesar unei dialize eficiente

A

250-450 ml/min

18
Q

Crearea fistulei arteriovenoase din

A

Artere radiala sau brahiala + vena cefalica

19
Q

Ce se utilizeaza daca nu putem folosi fistula

A

Cateter venos central tunelizat cu lumen dublu (longlife, semi-permanent) i venele jugulare sau femurale

20
Q

Simptome dializa ineficienta

A

Insomnie, prurit, astenie, sind picioarelor nelinistite, neuropatie senz perif

21
Q

Complicatii specifice dializa

A
  1. Malfunctie, tromboza, sangerare pe abordul vasc
  2. Bacteriemie / septicemie - artrita, endocardita, spondilodiscita
  3. Dezechil de dializa -> edem cerebral
  4. hTA intradialitica
  5. Amiloidoza
22
Q

Simptome peritonita bacteriana

A
  1. Febra
  2. Durere abd
  3. Drenaj lichid tulbure (>100 leucocite/mm3)
23
Q

Efecte adverse inhibitori de calcineurina

A
  1. NEfrotoxicitate
  2. HTA
  3. DZ
  4. Hirsutism
  5. Virilizare
24
Q

Efecte adverse inhibitori ai sintezei de purina

A
  1. Neutropenie
  2. Pancitopenie
  3. Afectare teste hepatice (AZA)
  4. DIaree (MMF)
25
Atc anti-CD25: ex, mecanism
Daclizumab, Basiliximab | Blocheaza rec pt IL-2
26
Atc anti-Ly T ex
``` ATG = globulina anti timocite OKT3 = atc monoclonal anti CD3 ``` * Distrug Ly T
27
Atc anti-CD52: ex, RA
Alemtuzumab | RA - Imunosupresie severa, risc de sepsis, malignitati
28
Ce e Belatacept
Atc anti-B7
29
Ce e Eculizumab + RA
Atc anti-C5a | RA - Infectii (meningita meningococica)
30
Complicatii precoce post transplant
1. Disfunctia precoce 2. Necroza tubulara acuta 3. Rejetul acut 4. Infectii
31
Complicatii tardive post transplant
1. Tulburari limfoproliferative 2. Tumori cutanate (trat imunosupresor) 3. Boli cardiovasculare 4. Osteoporoza 5. Recurenta bolii renale

Kumar (8 decks)

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