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Kumar > BCR > Flashcards

BCR Flashcards

1
Q

Ce det > 70% din toate cazurile de BCR

A
  1. DZ
  2. HTA
  3. Ateroscleroza
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2
Q

De ce depinde rata de declin a functiei renale

A
  1. Nefropatia de baza

2. Controlul HTA

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3
Q

Efecte angiotensina II

A
  1. Moduleaza pres capilara intragl si RFG
  2. Vasoconstrictia arteriolelor postgl
  3. Cresterea pres hidrostatice gl
  4. Cresterea fractiei de filtrare
  5. Stim prod de TGF beta si PAI-1
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4
Q

Prognosticul BCR se coreleaza cu

A
  1. HTA
  2. Proteinurie
  3. Gradul de lezare a interstitiului
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5
Q

Mecanismele anemiei normocrome normocitare

A
  1. Deficit de eritropoietina
  2. Pierderi de sange
  3. Afectare MO
  4. Deficit vit si minerale
  5. Distrugere crescuta eritrocite
  6. IECA
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6
Q

Agenti stimulatori ai eritropoiezei - ex, RA

A
  1. Epoetina - alfa, beta; Darbepoetina alfa

2. RA: HTA, encefalopatie, orbire corticala tranzitorie

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7
Q

Efecte FGF23

A
  1. Fosfaturie
  2. Inhiba 1alfa hidroxilaza renala
  3. Scade capacitatea vit D de a abs fosfat intestinal
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8
Q

Cel mai puternic predictor al mortalitatii in BCR

A

Nivelul crescut de FGF23

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9
Q

Modif biochimice caract hiperparatiroidismului sec

A
  1. Hipocalcemie
  2. Hiperfosfatemie
  3. Creste PTH
  4. Creste FA
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10
Q

Trat in reducerea fosforului si limitarea incarcaturii excesive cu Ca

A
  1. Restrictie dietetica
  2. Chelatori int de fosfor
  3. Chelatori int de fosfor cu Al
  4. Tenapanor
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11
Q

Chelatori int de fosfor

A

Carbonat Sevelamer, carbonat de lantan, carbonat si acetat de Ca

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12
Q

Trat in controlul PTH si obt unui nivel normal al Ca seric

A
  1. Calcitrol (1,25-(OH2)D3)
    Analogi vit D3 - alfacalcidol
    Noii metaboliti ai vit D3 - oxacalcitrol, paricalcitol, doxercalciferol
  2. Agenti calcimimetici - cinacalcet, etelcalcetid
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13
Q

Factori de risc in boala cardiovasculara

A
  1. HTA
  2. DZ
  3. Dislipidemia
  4. Fumat
  5. Barbati
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14
Q

Factori de risc in aparitia calcificarilor

A
  1. calciu x fosfor crescut
  2. hiperparatiroidism
  3. uremie
  4. inflamatie
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15
Q

Biopsia in FSN

A

Proliferarea fibrocitelor din derm cu depunere excesiva de colagen

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16
Q

Medicamente nefrotoxice

A
  1. tetracicline (exceptie doxi)
  2. gentamicina
  3. AINS
  4. spironolactona, amilorid
17
Q

Debitul sangvin necesar unei dialize eficiente

A

250-450 ml/min

18
Q

Crearea fistulei arteriovenoase din

A

Artere radiala sau brahiala + vena cefalica

19
Q

Ce se utilizeaza daca nu putem folosi fistula

A

Cateter venos central tunelizat cu lumen dublu (longlife, semi-permanent) i venele jugulare sau femurale

20
Q

Simptome dializa ineficienta

A

Insomnie, prurit, astenie, sind picioarelor nelinistite, neuropatie senz perif

21
Q

Complicatii specifice dializa

A
  1. Malfunctie, tromboza, sangerare pe abordul vasc
  2. Bacteriemie / septicemie - artrita, endocardita, spondilodiscita
  3. Dezechil de dializa -> edem cerebral
  4. hTA intradialitica
  5. Amiloidoza
22
Q

Simptome peritonita bacteriana

A
  1. Febra
  2. Durere abd
  3. Drenaj lichid tulbure (>100 leucocite/mm3)
23
Q

Efecte adverse inhibitori de calcineurina

A
  1. NEfrotoxicitate
  2. HTA
  3. DZ
  4. Hirsutism
  5. Virilizare
24
Q

Efecte adverse inhibitori ai sintezei de purina

A
  1. Neutropenie
  2. Pancitopenie
  3. Afectare teste hepatice (AZA)
  4. DIaree (MMF)
25
Q

Atc anti-CD25: ex, mecanism

A

Daclizumab, Basiliximab

Blocheaza rec pt IL-2

26
Q

Atc anti-Ly T ex

A 
ATG = globulina anti timocite
OKT3 = atc monoclonal anti CD3
  • Distrug Ly T
27
Q

Atc anti-CD52: ex, RA

A

Alemtuzumab

RA - Imunosupresie severa, risc de sepsis, malignitati

28
Q

Ce e Belatacept

A

Atc anti-B7

29
Q

Ce e Eculizumab + RA

A

Atc anti-C5a

RA - Infectii (meningita meningococica)

30
Q

Complicatii precoce post transplant

A
  1. Disfunctia precoce
  2. Necroza tubulara acuta
  3. Rejetul acut
  4. Infectii
31
Q

Complicatii tardive post transplant

A
  1. Tulburari limfoproliferative
  2. Tumori cutanate (trat imunosupresor)
  3. Boli cardiovasculare
  4. Osteoporoza
  5. Recurenta bolii renale

Kumar (8 decks)

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