Beckman Infertility

Question 1

Infertility affects what % of repro. Age women

Answer 1

15%

Question 2

Define Infertility

Answer 2

Inability to conceive after 1 year of unprotected frequent intercourse

Question 3

Fecundability Def.

Answer 3

Probability of achieving pregnancy within 1 menstrual cycle

Question 4

Fecundity Def.

Answer 4

Probability of achieving a live birth in one menstrual cycle

Question 5

6 steps of successful conception

Answer 5

1) ovulation of competent oocyte
2) prod. Of competent sperm
3) sperm meets egg in repro. tract
4) generation of viable embryo
5) transport embryo to uterine cavity
6) successful implantation

Question 6

Distribution (%) of infertility associated with men, women or idiopathic

Answer 6

Men: 20%
Women: 65%
Idiopathic: 15%

Question 7

Best predictor of ovulation

Answer 7

Regular predictable menses

Question 8

Progesterone changes the Thermo set point to what during the luteal phase

Answer 8

0.6 F higher than basal body temp

Question 9

Oocyte release occurs how many days prior to the first temperature spike

Answer 9

1 day

Question 10

Ovulation occurs how many hours after the LH surge

Answer 10

24 hours

Question 11

Initial Evaluation of Female Ovulation

Answer 11

H&P
Basal Body Temp charting
Ovulation Predictor kits (Urine LH)

Question 12

Further Eval of Female Ovulation

Answer 12

Mid luteal phase progesterone
Ultrasonography
Endocrine testing

Question 13

Female Uterus initial eval

Answer 13

Ultrasound

Question 14

Female Uterus further eval

Answer 14

Saline infusion sonography
Hysterosalpingography (HSG)
MRI
Hysteroscopy

Question 15

Fallopian Tubes and Peritoneum initial eval

Answer 15

HSG

Question 16

Fallopian tubes further eval

Answer 16

Laparoscopy and chromotubation

Question 17

Male initial eval

Answer 17

Semen analysis
Repeat semen analysis (?)
Postcoital test (not routine)

Question 18

Male further eval

Answer 18

Genetic testing
FSH, LH, T levels 
Prolactin level
Epididymal sperm aspiration 
Testicular biopsy

Question 19

Most common cause of ovulatory dysfunction in repro age women

Answer 19

PCOS

Question 20

Causes of amenorrhea

Answer 20

Prego
Hypothalamic dysfunction (stress)
Ovarian failure
Obstruction of repro tract

Question 21

When is uterine assessment particularly important

Answer 21

Hx of abnormal bleeding, preg loss, preterm delivery, previous uterine surgery

Question 22

What day of fertilization during normal pregnancy does the embryo enter the endometrial cavity

Answer 22

Day 5

Question 23

HSG captures what % of anatomic abnormalities

Answer 23

70%

Question 24

During semen analysis how is the semen collected

Answer 24

Masturbation 🍻 - after 2-3 days of abstinence

Question 25

Sperm conc. Of healthy semen

Answer 25

15 million/mL

Question 26

Sperm production and development takes _____ days

Answer 26

70

Question 27

Low LH + Oligospermia (<5 million/mL) + normal T = ________

Answer 27

Exogenous steroid use 💉

Question 28

Most common genetic abnormalities in men

Answer 28

Cystic Fibrosis
Somatic and Sex Chromosome Abnormalities
Micro deletions of Y chromosome

Question 29

Advanced paternal age ____ rates of ______ mutations

Answer 29

Increased; Autosomal-Dominant