Beckman Menopause Flashcards
____ consecutive months with no menstrual bleeding is diagnostic for menopause.
12 months
Follicular maturation is induced and stimulated by what two hormones?
FSH and LH
Plasma concentrations of what hormone begin to increase several years before menopause
FSH, usually found to be >30mIU/mL due to oocytes becoming more resistant to FSH
T/F The age of menopause is influenced by menarche, OCP use, and race.
False, age of menopause is only influenced by genetic and lifestyle factors (malnourished and smokers tend to have earlier menopause)
What is premature ovarian failure
When women undergo menopause before age 40 (~1% of women)
After menopause what hormone is mainly produced by the ovaries
Androstenedione, which gets peripherally converted to Estrone (E1) dependent on the amount of fatty tissue
Which population of post-menopausal women is at a higher risk for endometrial hyperplasia? Menopausal symptoms?
Endometrial Hyp - obese women because estrogen promotes endometrial proliferation
Symptoms - slender women
FSH level during prime reproductive years
6-10 mIU/mL
Which phase of the menstrual cycle remains constant and how long is it
Luteal Phase - 13-14 days
What is the first symptom of dec. ovarian function (perimenopause)
Hot Flashes, due to vasomotor instability
Commons symptoms associated with menopause
Hot flashes, vaginal dryness, mood/memory changes, skin/hair changes, osteoporosis, lipid changes (inc. cholesterol and LDL, dec. HDL)
Recommended Calcium and Vitamin D doses during menopause to prevent bone loss
1200mg Calcium
600mg Vitamin D
T/F 17-Beta Estradiol (E2) gets converted to Estrone (E1) only when administered orally
True, when E2 is administered trans- dermal/buccal/vaginal or IV/IM it is unaltered
In women who have not undergone hysterectomy what hormone in addition to estrogen should you give during HRT
Progestin, to protect against unopposed estrogen –> endometrial hyperplasia
Risks of HRT
MI, Stroke, Thromboembolic disease, Breast Cancer
