BETA Blockers

Question 1

What are the types of BETA adrenergic receptor antagonists

Answer 1

• Non selective first generation
• B1- selective second generation
• Non selective third generation
• B1-selective third generation

Question 2

Non selective first generation antagonist drugs

Answer 2

• Nadolol
• propranolol
• Timolol
• Sotalol

Question 3

B1-selective second generation antagonist drugs

Answer 3

• Atenolol
• Bisoprolol
• Esmolol
• Metoprolol

Question 4

Non selective third generation antagonist drugs

Answer 4

• Carvedilol
• Labetalol

Question 5

B1-selective third generation antagonist drugs

Answer 5

nebivolol

Question 6

B1-Receptor heart function

Answer 6

• heart rate
• contractility
• automaticity
• conduction velocity

Question 7

B2-Receptor function lungs

Answer 7

• Bronchorelaxation

Question 8

B1- receptor function in kidneys

Answer 8

renin release in kidneys

Question 9

B2- receptor function in skeletal muscle

Answer 9

• vasodilation
• glycogenolysis

Question 10

B2- receptor function in liver

Answer 10

• Glycogenolysis
• Gluconeogenesis

Question 11

1/2 life of most B-antagonist

Answer 11

3-10 hours

Question 12

what drug is the exception to the 1/2 life rule

Answer 12

Esmolol. Has a 1/2 life of 10 minutes

Question 13

What drugs are not limited to varying degrees due to first pass metabolism

Answer 13

Betaxolol, Penbutolol, pindolol, sotalol

BePPiS

Question 14

partial agonists

Answer 14

Depends on the activity of the sympathetic nervous system

EX: ligand for receptor is high the drug acts as antagonist, if it is low drugs can bind and activate it

Question 15

what drugs block a1 receptors?

Answer 15

Labetalol, carvedilol

Question 16

Vasodilator drugs

Answer 16

Nebivolol

Question 17

Antioxidant drugs

Answer 17

Carvedilol

Question 18

BETA blocker effects on the eye

Answer 18

Reduce the intraocular pressure and decrease aqueous humor

Question 19

Why is it a bad idea to abruptly stop taking a BETA blocker

Answer 19

Your sympathetic nervous system is upregulated while taking which could cause a angina and increase risk of sudden death

Question 20

CNS effects with BETA blockers

Answer 20

• Fatigue
• Depression
• sleep disturbances

No clear correlation

Question 21

Propranolol clinical use

Answer 21

Treats hypertension, Angina pectoris , cardiac arrhythmias, myocardial infraction, and pheochromocytoma, migrane, tremor

Question 22

propranolol adverse effects

Answer 22

cardiovascular, bradycardia, hypotension, heart failure, fatigue ,withdrawal symptoms, bronchospasm,

Question 23

timolol Clinical use

Answer 23

Treatment of glaucomal, which decreases aqueous humor concentration

(Timmy got sum glasses)

Question 24

metoprolol clinical use

Answer 24

Hypertension,Cardiovascular, angima, congestive heart
failure C.A.C.H

(slows heart)

Question 25

Metroprolol adverse effects

Answer 25

Overlap with propranolol . Less risk of bronchoconstriction. Mediated by B2 receptors -blurry, bradychardia, hypotension : METRO TOOK A BEAN

Question 26

Esmolol clinical use

Answer 26

(B1) Administered when a beta blockade of short duration is desired. Mainly used to treat tachycardia

Question 27

Esmolol Adverse Effect

Answer 27

Ultra short acting 1/2 life of 8 minutes

Question 28

labetalol function

Answer 28

Antagonist for Beta 1 and Beta 2 receptors as well as Alpha 1 receptors Treats hypertensive emergencies

Question 29

Labetalol clinical use

Answer 29

treats hypertension and treats hypertensive emergency

Question 30

carvedilol function

Answer 30

antagonist for Alpha 1 and both beta receptors, but has anti-oxidant and anti inflammatory type properties - Slows heart making it easier for blood pumping

Question 31

carvedilol clinical use

Answer 31

treat acute myocardial infraction, HTN, and heart failure MHH

Question 32

Nebivolol function

Answer 32

B1 antagonist and stimulates nitric oxidate release.

Question 33

Nebivolol clinical use

Answer 33

treat hypertension

Question 34

drugs used following a myocardial infraction

Answer 34

Timolol, Propranolol, metoprolol

Question 35

advantages of beta blockers in cardiac arrythmias

Answer 35

slows ventricular response rates to atrial flutter and fibrillation

Question 36

advantages of beta blockers in heart failure

Answer 36

effective in reducing mortality in patients with chronic heart failure

Question 37

drugs to reduce heart failure

Answer 37

metoprolol, bisoprolol, and carvedilol M.B.C

Question 38

What type of beta blockers are suitable for local use in the eye

Answer 38

Beta blockers that lack local anesthetic properties

Question 39

Beta blocker affects on hyperthyroidism

Answer 39

Beta blockers assist and make symptoms better in hyperthyroidism

Question 40

Beta blockers for migraines

Answer 40

propranolol, metoprolol, timolol: PMT (same drugs used for post acute MI) probably effective: atenolol, nadolol

Question 41

Beta blocker for anxiety and tremors

Answer 41

propranolol

Question 42

When choosing a beta blocker what must be considered

Answer 42

comorbidities such as diabetes or other diseases