beta lactams

Question 1

beta lactam classes

Answer 1

1. Penicillins
2. Cephalosporins
3. Carbapenems
4. Monobactam

Question 2

N.penicillins are effective against:

Answer 2

G+ve ex: S. pyogenes
viridans faecalis
+ N.G

Question 3

N.penicillins are ineffective against:

Answer 3

MRSA
G-VE

Question 4

N. penicillins treat

Answer 4

Necrotizing faecalis
Syphilis

RF
Endocarditis

Question 5

Anti-staph penicillins examples

Answer 5

nafcillin (IV)
Dicloxacillin (ORAL)

Question 6

Anti-staph penicillins effective

Answer 6

MSSA , viridans , faecialis , pyogenes

Question 7

Anti-staph penicillins ineffective

Answer 7

MRSA , B. fragilis , aerobic g-ve

Question 8

Anti-staph penicillins treat

Answer 8

cellulitis , skin infections (SA)

Question 9

Anti-Pseudomonas Penicillins examples

Answer 9

Piperacillin +/ tazocin ( with tazobactam)

Question 10

Anti-Pseudomonas Penicillins effective

Answer 10

Alone: PA
Tazocin: anaerobes (BF) , Strep , MSSA

Question 11

Anti-Pseudomonas Penicillins ineffective

Answer 11

MRSA , ESBL

Question 12

Anti-Pseudomonas Penicillins treat

Answer 12

hospital & polymicrobial infections
(ps CAN’T TREAT MENINGITIS)

Question 13

Anti-Pseudomonas ADVERSE EFFECTS

Answer 13

interstitial nephritis + nephrotoxicity (if combined with vancomycin)

Question 14

Aminopenicillins examples

Answer 14

ampicillin , amoxicillin (helps absorption)

Question 15

Aminopenicillins effective

Answer 15

enterococci , enterobacterals , strep (ex agalactiae) , listeria

Question 16

Aminopenicillins ineffective

Answer 16

PA , MRSA

Question 17

Aminopenicillins treat

Answer 17

Neonatal Meningitis , H.pylori , endocarditis , community inf , prophylaxis in preg.

Question 18

cefazolin

Answer 18

1st generation

Question 19

cefazolin effective

Answer 19

MSSA , pyogenes , agalactiae , “enterobacterals & ecoli”

Question 20

cefazolin ineffective

Answer 20

BALME: BF , atypicals , l.monocytogenes , MRSA, enterococci

Question 21

cefazolin treats

Answer 21

surgical prophylaxis

Question 22

Cefuroxime

Answer 22

2nd generation

Question 23

Cefuroxime effective

Answer 23

H.I , MSSA , pyogenes , agalactiae , enterobacteriacae

Question 24

Cefuroxime ineffective

Answer 24

BALME

Question 25

Ceftriaxone

Answer 25

3rd ex: ceftazidime

Question 26

Ceftriaxone effective

Answer 26

HI , pneumococci , MSSA , Enterobacterals , PA

Question 27

Ceftriaxone ineffective

Answer 27

BALME

Question 28

Ceftriaxone treats

Answer 28

meningitis

Question 29

Ceftriaxone Adverse effects

Answer 29

kernicterus , cholelithiasis , cholestasis

Question 30

Cefepime

Answer 30

4th

Question 31

Cefepime effective

Answer 31

MSSA, Strep , PA , enterobacterales c.

Question 32

Cefepime ineffective

Answer 32

BALME

Question 33

Ceftaroline

Answer 33

5th

Question 34

Ceftaroline effective

Answer 34

MRSA , strep , PA , enterobacterals

Question 35

Ceftaroline ineffective

Answer 35

BALE + ESBL

Question 36

Imipenem

Answer 36

carbapenem (most potent BL)

Question 37

Imipenem effective

Answer 37

ESBL , entercocci Faceium , enterbacterals ,anaerobes

Question 38

Imipenem ineffective

Answer 38

MRSA , S. maltophilia

Question 39

Imipenem adverse effects

Answer 39

seizures

Question 40

Monobactam

Answer 40

Aztreonam

Question 41

Monobactam effective

Answer 41

Gram -ve : PA

Question 42

Monobactam ineffective

Answer 42

G+ve , anaerobes

Question 43

Vancomycin MOA

Answer 43

blocks transpeptidase

Question 44

Vancomycin effective

Answer 44

penicillin R. strep pneumoniae , MRSA , S.epi , C. difficile

Question 45

Vancomycin ineffective

Answer 45

G-ve

Question 46

Vancomycin treats

Answer 46

hospital acquired pneumonia , bacteremia , PC

Question 47

Vancomycin adverse effects

Answer 47

nephrotoxicity , red man syndrome (histamine) require TDM