Cholinergic Agonists

Question 1

Parasympathomimetics actions (Cholinergic)

Answer 1

Decreases heart rate & CO
Bronchoconstriction , Miosis
Increases GI tract motility +lacrimation + urination

Question 2

Nicotinic Receptors Types

Answer 2

Muscular/NMJ (Nm) / Ganglionic (Nn)

Question 3

Muscarinic Receptors Types

Answer 3

M1- Gq (neural , gastric), M2- Gi (cardiac), M3-Gq (glandular/smooth muscle),

Question 4

Bethanechol Type

Answer 4

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

Question 5

Bethanechol Uses

Answer 5

Urinary Retention

Question 6

Bethanechol MOA

Answer 6

increases bladder smooth muscle tone

Question 7

Bethanechol Side Effects

Answer 7

generalized cholinergic stimulation

Question 8

Carbachol

Answer 8

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

Question 9

Carbachol Uses

Answer 9

Glaucoma

Question 10

Carbachol MOA.

Answer 10

miosis (Muscarinic & Nicotinic)

Question 11

Pilocarpine

Answer 11

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

Question 12

Pilocarpine Uses

Answer 12

Glaucoma , Xerostomia

Question 13

Pilocarpine MOA

Answer 13

miosis , inc. sweat , tears , & saliva (M. effect)

Question 14

Methacholine

Answer 14

Direct Acting Cholinergic Agonist (doesn’t Cross BBB)

Question 15

Methacholine MOA

Answer 15

Bronchoconstriction

Question 16

Methacholine Uses

Answer 16

diagnose bronchial hypersensitivity (Methacholine Challenge Test)

Question 17

Physostigmine

Answer 17

Indirect acting cholinergic agonist (inhibits AchE)

Question 18

Physostigmine Uses

Answer 18

Glaucoma (not v effective) , Atropine/tricyclic AD overdoses , used to increase intestinal & bladder motility

Question 19

Physostigmine Side Effects

Answer 19

Convulsions , bradycardia , skeletal muscle paralysis (high doses)

Question 20

Neostigmine

Answer 20

Indirect acting cholinergic agonist (inhibits AchE)

Question 21

Neostigmine Uses

Answer 21

Treats Myasthenia Gravis (greater effect on Nm) , antidote for tubocurarine

Question 22

Edrophonium

Answer 22

Indirect acting cholinergic agonist (inhibits AchE)

Question 23

Edrophonium Uses

Answer 23

Diagnosis of MG

Question 24

Donepezil, Rivastigmine, Galantamine Uses

Answer 24

delay progression of Alzheimer’s

Question 25

Donepezil, Rivastigmine, Galantamine

Answer 25

Indirect acting cholinergic agonist (inhibit AchE)

Question 26

Nerve Gaz (sarin)

Answer 26

Indirect Acting Cholinergic Agonists: Irreversible

Question 27

Nerve Gaz Effects

Answer 27

Respiratory depression

Question 28

Echothiophate

Answer 28

Indirect Acting Cholinergic Agonists: Irreversible

Question 29

Echothiophate Uses

Answer 29

Glaucoma

Question 30

Pralidoxime MOA

Answer 30

Reactivation of inhibited AChE

Question 31

Pralidoxime Uses

Answer 31

treat organophosphate and pesticide poisoning

Question 32

Ach Cardiovascular Actions

Answer 32

decreases HR : M2-R (inhibit AC & Ca entry) , Decreases BP : M3-R (nitric oxide= SM relaxation)

Question 33

Ach GI + Eye actions

Answer 33

Increases salivary secretion & motility Contraction: colicky pain / expulsion of urine (Tone of muscle is increased) / miosis

Question 34

Ach Adverse Effects

Answer 34

Diarrhea , nausea , urinary urgency , miosis , diaphoresis

Question 35

Nicotine Actions

Answer 35

Low doses: stimulation of ganglionic nicotinic receptors → enhancing S (BV) and PS (heart+GI) High doses: depolarizing blockade of ganglia

Question 36

Suxamethonium MOA

Answer 36

Depolarizing Nm blocker (agonist)