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MT 6314 PCOL > Beta-Lactams Antibiotics Cephalosporins & Cephamycins > Flashcards

Beta-Lactams Antibiotics Cephalosporins & Cephamycins Flashcards

(55 cards)

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1
Q

Derivatives of 7-aminocephalosporanic acid. More stable to many bacterial B-lactamases

A

Cephalosporins & Cephamycins

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2
Q

Cephalosporins that are excreted in bile

A

Cefoperazone and Ceftriaxone

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3
Q

Cephalosporins major elimination are via

A

renal tubular excretion

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4
Q

First-Generation Cephalosporins

A

Cephalexin, Cefazolin, Cefadroxil, Cephalotin, Cephadrine, Cephapirin

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5
Q

Second-Generation Cephalosporins

A

Cefuroxime, Cefoxitin, Cefotetan, Cefamandole, Cefaclor

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6
Q

Third-Generation Cephalosporins

A

Ceftriaxone, Cefotaxime, Cefoperazone, Ceftazidime, Cefixime

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7
Q

Fourth-Generation Cephalosporins

A

Cefepime

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8
Q

_______ and ______ gen don’t enter CSF even if meninges are inflamed

A

1st and 2nd

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9
Q

Not active against MRSA
a. First Gen
b. Fourth Gen

A

a. First Gen

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10
Q

Drug of choice against gram (+) cocci
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

c. Both

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11
Q

Drug of choice against E. coli
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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12
Q

Drug of choice against K. pneumoniae
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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13
Q

Drug of choice to treat Surgical Prophylaxis
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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14
Q

Drug of choice to treat cellulitis
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

b. Cephalexin

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15
Q

Drug of choice to treat Soft Tissue abscess
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

b. Cephalexin

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16
Q

Drug of choice to treat Skin and Soft Tissue Infections
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

c. Both

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17
Q

Toxicity of Drug fever is associated with
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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18
Q

The only 1st gen parenteral drug still in use

A

Cefazolin

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19
Q

Drug of choice against Pneumococcus
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

a. Cefuroxime

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20
Q

Drug of choice against H. influenzae
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

a. Cefuroxime

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21
Q

Drug of choice against Anaerobes
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

b. Cefotetan

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22
Q

Drug of choice against Serratia
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

b. Cefotetan

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23
Q

Resistant to Serratia
a. Cefotetan
b. Cefoxitin
c. Cefuroxime

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A

c. Cefuroxime

24
Q

Drug of choice to treat commonly-acquired pneumonia
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

Study These Flashcards
A

a. Cefuroxime

25
Drug of choice to treat Mixed Anaerobic Infections a. Cefuroxime b. Cefoxitin c. Cephalexin
b. Cefoxitin
26
Drug of choice to treat Pelvic Inflammatory Disease a. Cefuroxime b. Cefoxitin c. Cephalexin
b. Cefoxitin
27
Drug of choice to treat Peritonitis a. Cefuroxime b. Cefoxitin c. Cephalexin
b. Cefoxitin
28
Drug of choice to treat Diverticulitis a. Cefuroxime b. Cefoxitin c. Cephalexin
b. Cefoxitin
29
Most active cephalosporins against penicillin-resistant pneumococci (PRSP)
Ceftriaxone
30
Cephalosporins that cannot penetrate the BBB
cefoperazone and cefixime
31
Third-Generation Cephalosporins that the only agent w/ useful activity against P. aeruginosa
Ceftazidime
32
Not for gonococcal urethritis and cervicitis a. Cefotaxime b. Ceftazidime c. Cefixime
c. Cefixime
33
Drug of choice to treat Pneumonia a. Ceftriaxone b. Cefotaxime c. Both d. Neither
a. Ceftriaxone
34
Drug of choice to treat Osteomyelitis a. Ceftriaxone b. Cefotaxime c. Both d. Neither
a. Ceftriaxone
35
Drug of choice to treat Empiric Therapy for Serious Infections a. Ceftriaxone b. Cefotaxime c. Both d. Neither
c. Both
36
Drug of choice to treat Acute Otitis Media a. Ceftriaxone b. Cefotaxime c. Both d. Neither
a. Ceftriaxone
37
Drug of choice to treat Meningitis a. Ceftriaxone b. Cefotaxime c. Both d. Neither
c. Both
38
Drug of choice to treat Pyelonephritis a. Ceftriaxone b. Cefotaxime c. Both d. Neither
a. Ceftriaxone
39
Drug against MRSA (Methicillin-Resistant Staphylococcus aureus) a. Cefepime b. Ceftaroline c. both d. neither
b. Ceftaroline
40
Drug against MSSA (Methicillin-Susceptible Staphylococcus aureus) a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
41
Drug against Enterobacteriacaea a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
42
Drug against Haemophilus a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
43
Drug against Neisseria a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
44
First drug approved for MRSA
Ceftaroline
45
Drug of choice to treat complicated P. aeruginosa infections a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
46
Drug against Febrile Neutropenia a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
47
Drug against community-acquired pneumonia a. Cefepime b. Ceftaroline c. both d. neither
b. Ceftaroline
48
Drug that penetrates well to cerebrospinal fluid a. Cefepime b. Ceftaroline c. both d. neither
a. Cefepime
49
More resistant to hydrolysis by chromosomal B- lactamase but hydrolyzed by ESBL
Cefepime
50
carbapenemase- producing organisms a. Ceftazidime- avibactam b. Ceftolozane- tazobactam c. both d. neither
a. Ceftazidime- avibactam
51
Bound by active iron transporters and pumped into the bacterial cell wall at high conc
Cefiderocol
52
Resistant to P. aeruginosa a. Ceftaroline b. Ceftazidime c. Cefiderocol
a. Ceftaroline
53
Resistant to Organisms w/ metallo-B-lactamase a. Ceftaroline b. Ceftazidime c. Cefiderocol
b. Ceftazidime
54
Resistant to Gram (+) anaerobic organisms a. Ceftaroline b. Ceftazidime c. Cefiderocol
c. Cefiderocol
55

MT 6314 PCOL (3 decks)

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