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Pharmacology 2 > Beta-Lactams from Cell Wall Synthesis Inh. and Incomplete Intro to Beta Lactams Pt 2 > Flashcards

Beta-Lactams from Cell Wall Synthesis Inh. and Incomplete Intro to Beta Lactams Pt 2 Flashcards

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1
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

Methicillin

A

penicillin/Penicillinase-Resistant Penicillins (Anti-staphylococcal Penicillins)

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2
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

nafcillin

A

penicillin/Penicillinase-Resistant Penicillins (Anti-staphylococcal Penicillins)

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3
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

oxacillin

A

penicillin/Penicillinase-Resistant Penicillins (Anti-staphylococcal Penicillins)

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4
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

Ampicillin

A

penicillin/Extended Spectrum Penicillins (± BLI combos)

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5
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

amoxicillin

A

penicillin/Extended Spectrum Penicillins (± BLI combos)

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6
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

Piperacillin

A

penicillin/Extended Spectrum Penicillins (± BLI combos)

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7
Q

Identify the penicillin/s:

Very narrow spectrum

A

Methicillin, nafcillin, oxacillin

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8
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

ticarcillin

A

penicillin/Extended Spectrum Penicillins (± BLI combos)

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9
Q

Identify the penicillin/s:

Not used much

A

Methicillin, nafcillin, oxacillin

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10
Q

Identify the penicillin/s:

emergence of MRSAs has essentially taken this drug off the table in terms of our choice (based on the video)

A

Methicillin

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11
Q

Identify the penicillin/s:

linked to interstitial nephritis

A

Methicillin

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12
Q

Identify the penicillin/s:

associated with neutropenia

A

Nafcillin

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13
Q

Identify the penicillin/s:

Wider spectrum, still susceptible to B-lactamases

A

Ampicillin, amoxicillin

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14
Q

Identify the penicillin/s:

Enhanced when used with clavulanate

A

Ampicillin, amoxicillin, ticarcillin

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15
Q

Identify the penicillin/s:

In eneterococcal infections, _______ is complementary with aminoglycosides

A

ampicillin

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16
Q

Identify the penicillin/s:

_________-gentamicin is commonly used because they work together

A

Ampicillin

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17
Q

Identify the penicillin/s:

Strong activity against gram-negative organisms

A

Piperacillin, ticarcillin

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18
Q

Identify the penicillin/s:

Complementary actions with aminoglycosides

A

Piperacillin, ticarcillin

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19
Q

piperacillin may be combined with _______ to produce a powerful effect against gram-negative organisms

A

tobramycin

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20
Q

Identify the penicillin/s:

Susceptible to penicillinases, used with tazobactam to limit resistance

A

Piperacillin, ticarcillin

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21
Q

Identify which beta-lactamase inhibitor is combined with:

amoxicillin

A

Clavulanic acid (amoxicillin-clavulanate)

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22
Q

Identify which beta-lactamase inhibitor is combined with:

ampicillin

A

sulbactam, clavulanate

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23
Q

Identify which beta-lactamase inhibitor is combined with:

piperacillin

A

Tazobactam

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24
Q

Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous:

Cefalozin

A

First generation cephalosporins

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25
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cephalexin
First generation cephalosporins
26
Identify the cephalosporin/s: more gram-positive active
Cefalozin, cephalexin (First generation cephalosporins)
27
Identify the cephalosporin/s: Used in surgical infections
Cefalozin, cephalexin (First generation cephalosporins)
28
T/F a lot of infections come from skin surface agents and pseudomonas aeruginosa
F Staphylococcus aureus
29
Identify the cephalosporin/s: Minimal effectiveness against gram-negative bacteria
Cefalozin, cephalexin (First generation cephalosporins)
30
Identify the cephalosporin/s: prototypical agent for Second generation cephalosporins
cefotetan
31
Identify the cephalosporin/s: Will also work against Haemophilus influenzae
Cefotetan, cefoxitina, cefamandole, cefuroxime, cefaclor (Second generation cephalosporins)
32
Identify the cephalosporin/s: commonly used in pneumonia treatment
cefuroxime
33
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Cefotetan
Second generation cephalosporins
34
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefoxitina
Second generation cephalosporins
35
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefamandole
Second generation cephalosporins
36
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefuroxime
Second generation cephalosporins
37
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefaclor
Second generation cephalosporins
38
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Ceftazidime
Third generation cephalosporins
39
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefoperazone
Third generation cephalosporins
40
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: cefotaxime
Third generation cephalosporins
41
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: ceftriaxone
Third generation cephalosporins
42
Identify the cephalosporin/s: Even more active against gram-negative
Ceftazidime, cefoperazone, cefotaxime, ceftriaxone (Third generation cephalosporins)
43
Identify the cephalosporin/s: go-to drug for 3rd generation agents, very good gram-negative agent
cefotaxime
44
Identify the cephalosporin/s: Will often work against organisms that are resistant to penicillin
Ceftazidime, cefoperazone, cefotaxime, ceftriaxone (Third generation cephalosporins)
45
Identify the cephalosporin/s: We only use these drugs in serious infections
Ceftazidime, cefoperazone, cefotaxime, ceftriaxone (Third generation cephalosporins)
46
Identify the cephalosporin/s: In general, they are only available in intravenous form
Ceftazidime, cefoperazone, cefotaxime, ceftriaxone (Third generation cephalosporins)
47
Identify the beta lactam class : highly associated with rash and allergy
penicillins
48
Identify the cephalosporin/s: prototypical agent of 4th generation cephalosporins
Cefepime
49
Identify the cephalosporin/s: More resistant to B-lactamases
Cefepime, ceftaroline (Fourth generation cephalosporins)
50
Identify the cephalosporin/s: Effective against Eneterobacter, Haemophilus, Neisseria
Cefepime, ceftaroline (Fourth generation cephalosporins)
51
Identify the cephalosporin/s: 4th generation cephalosporin which has activity in infections caused by methicillin resistant staphylococci
ceftaroline
52
_____________ are less likely to cause rashes and allergic reactions than penicillins
Cephalosporins
53
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: PCN-G
penicillin/Penicillin A-Sensitive PCNs (Natural Penicillins)
54
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: PCN-V
penicillin/Penicillin A-Sensitive PCNs (Natural Penicillins)
55
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Dicloxacillin
penicillin/Penicillinase-Resistant Penicillins (Anti-staphylococcal Penicillins)
56
Identify the cephalosporin/s: similar to 3rd generation cephalosporins, with respect to a broad spectrum of activity against gram-negative bacteria
Ceftaroline, ceftobiprole (Fifth Generation)
57
Identify the cephalosporin/s: have activity against gram-positive bacteria, including MRSA, as good as vancomycin and aztreonam
Ceftaroline, ceftobiprole (Fifth Generation)
58
Identify the cephalosporin/s: Have activity in infections caused by methicillin resistant staphylococcus aureus (MRSA)
Ceftaroline, ceftobiprole (Fifth Generation)
59
Identify the cephalosporin/s: 5th generation cephalosporin used for Community acquired pneumonia
Ceftaroline, ceftobiprole
60
Identify the cephalosporin/s: 5th generation cephalosporin used for hospital acquired pneumonia
Ceftobiprole
61
Identify the cephalosporin/s: 5th generation cephalosporin administered as Intravenous drug only
Ceftobiprole
62
Identify the cephalosporin/s: 5th generation cephalosporin that is not available in all countries
Ceftaroline
63
Identify the cephalosporin/s: 5th generation cephalosporin that is not available in most countries yet
Ceftobiprole
64
Identify the drug: Resistant to B-lactamases
Aztreonam
65
T/F Aztreonam is not commonly used in clinical practice
T
66
T/F Aztreonam has activity against gam-positive drugs
F no activity
67
Identify the drug: Binds to penicillin-binding protein 3 (PBP3)
Aztreonam
68
Identify the drug: Binds to penicillin-binding protein 2b (PBP2b) in MRSA
Ceftobiprole (5th gen cephalosporin)
69
Identify the drug: Adverse events - GI upset - Vertigo, headache
aztreonam
70
T/F aztreonam has no cross allergy with penicillins
T
71
Identify the drug: Powerful agents (gorillacillins)
Imipenem, doripenem, meropenem (carbapenems)
72
Identify the drug: Broad-spectrum activity against gram positives, gram negatives, anaerobes, and Pseudomonas.
Imipenem, doripenem, meropenem (carbapenems)
73
Identify the drug: Chemically unique, but still containing a B-lactam ring
Imipenem, doripenem, meropenem (carbapenems)
74
T/F carbapenems have high susceptibility to penicillinases
F low
75
Identify the drug: Very susceptible to renal dehydropeptidases
Imipenem, doripenem, meropenem (carbapenems)
76
carbepenem is Administered with _______ to inhibit renal dehydropeptidases
silastatin
77
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Imipenem
Carbapenems
78
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: doripenem
Carbapenems
79
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: meropenem
Carbapenems
80
Identify the drug: Bactericidal glycoprotein that binds to the alanine terminal of the peptidoglycan
Vancomycin
81
Identify the drug: Resistant organisms have an altered terminal will have decreased affinity for this drug
Vancomycin
82
Identify the drug (non-cephalosporin): Used for serious infections only
Vancomycin
83
Identify the drug: is a large molecule
Vancomycin
84
T/F vancomycin crosses the blood brain barrier
F does not cross
85
Identify the drug: used intrathecally (if you have a spinal infection or brain infection)
Vancomycin
86
Identify the drug: Used orally for luminal infections of the gut
Vancomycin
87
Identify the drug: “Red man syndrome”
Vancomycin
88
Identify the drug: May cause phlebitis, ototoxicity, nephrotoxicity
Vancomycin
89
severe cutaneous flushing from histamine release (not allergy)
“Red man syndrome"
90
Identify the drug: Used in topical treatment and decontamination syndromes
Bacitracin
91
Identify the drug: Used in staphylococcus colonization of the skin
Bacitracin
92
Identify the drug: Marked nephrotoxicity - not used parenterally or orally
Bacitracin
93
Identify the drug: Cyclic lipopeptide
Daptomycin
94
Identify the drug: For the treatment of VRE and VRSA
Daptomycin
95
Identify the drug: Monitor creatinine kinase during treatment
Daptomycin
96
Identify the drug: is myopathic
Daptomycin
97
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Aztreonam
miscellaneous (monobactam)
98
Classify as penicillin (including type)/cephalosporin (including generation)/carbapenem/miscellaneous: Vancomycin
miscellaneous
99

Pharmacology 2 (2 decks)

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