Biguanidele Flashcards

1
Q

reprezentanti

A

metformin
buformin

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2
Q

reprezentanti metformin

A

siofor 500, 850 mg
meguan( diguan) 500mg
metfogama 500mg
glucofage 850mg, 1000 mg
* 2-3 prize
*max 2500mg/zi

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3
Q

reprezentati buformin

A

silubin 100
diabiten 100

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4
Q

administrare

A

postprandial
initiere cu 250 mg
titrare saptamanala
efectele apar in 3-5 zile
devin maxime in 1-2 saptamani
se asociaza cu oricare alt antidiabetic

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5
Q

efecte adverse

A

acidoza lactica fatala in 50% din cazuri
reactii g-i dispar in cateva zile
cresc enzimele hepatice
scade absorbtia intestinala de B12

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6
Q

contra indicatii

A

IR
IC congestiva
hepatopatie cronica cu transaminaze cu 3x crescute
bolnavii peste 80 de ani
deficit de B12
dz1
traumatisme severe
infectii grave
soc
se intrerupe cu 48 de ore in cadrul administrarii preparate iod

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