Binary decision: Neurogenesis Flashcards Preview

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Flashcards in Binary decision: Neurogenesis Deck (6)
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1
Q

What are the fates of progenitors?

A
  • Move laterally and differentiate into mature neurons in mantle zone.
  • not undergo differentiation into neurons and stay in ventricular zone (central lumen)
2
Q

What happens to the neurons that do not differentiate?

A

Exist as Radial Glia (neural stem cells)

They provide a pool of undifferentiated cells that are used to build up the nervous system over time in embryogenesis

3
Q

What do we call the early neural tube?

A

neuroepithelium/neuralepithelial cells

4
Q

Progentior cells (neuroepithelium cells) that proliferate

A

Their nuclei undergo interkinetic migration.
In G1 and S phase of the cell cycle, the Nucleus is away from the lumen.
At M phase and cytokinesis, the nucleus is close to the lumen.
At cytokinesis, the lateral attachment is lost, then reforms

5
Q

How can neuroepithelial cells divide and give rise to

A

Early neuroepithelial cells can divide Symmetrically, generating 2 identical
daughters.
These start to change shape and become Radial glial-like – ie cells with a longer Process.

6
Q

How do Radial Glia divide and what do they give rise to

A

Radial glia can divide asymmetrically, giving rise to one daughter which is like its mother – ie a radial glia (stem cell), and a 2nd daugher that will differentiate to a neuron. This daughter uses the scaffold provided by its sister to migrate away from the ventricular zone