Biochem 22: glycolysis Flashcards
Glycolysis begins with
Phosphorylation of glucose to G6P by hexokinase
Net energy for glycolysis
-2 ATP + 4ATP= +2 ATP
+2 NADH
Glycolysis occurs in
Cytoplasm
Complete aerobic oxidation of glucose to CO2 produces
30-32 ATP per glucose
Hexokinase is inhibitted by
G6P
Control of G6P entry into glycolysis is by what enzyme
PFK-1
PFK is inhibitted by ____ and activated by ______
In what fashion
Inhibitted by ATP
Activated by AMP
In addition to energy, pyruvate is a precursor to
Fatty acid synthesis
Essential fructosuria cause
Fructokinase deficiency
Hereditary fructose intolerance cause
Deficiency of fructose 1-p cleavege by aldolase B
Polyol pathway steps
Aldose reductase converts glucose to sorbitol which is then oxidized to fructose
How is galactose converted to glucose
Galactose is phosphorilated by galactokinase into Galactose-1-P
Galactose-1-p is activated by galactosyl urydil transferase into Glucose-1-P
Classical galactosemia cause
Galactosyl uridyltransferase deficiency. Galactose-1-p accumulates
Branch point of carbohydrate metabolism
G6P
can either get used for glycolysis, pentose phosphate or glycogen
Rate limiting enzyme of fructose metabolism
Aldolase B
