Pharm 10: Cholinergic Pharm

Question 1

Muscarinic acetylcholine receptor type and location

Answer 1

G-protein

All parasympathetics, few sympathetics, CNS

Question 2

Nicotinic Acetylcholine receptor type and location

Answer 2

Ligand gated

Post synaptic in excitatory ANS

Presynaptic in CNS

Question 3

Acetylcholine synthesis _____+______= acetylcholine

what enzyme?

Answer 3

Acetyl CoA+ Choline

Choline acetyltransferase

Question 4

How does choline get into neuron

Answer 4

NA+/Choline co-transporter

Question 5

How does choline get into vesicle

Answer 5

AcH/H+ cotransporter

Question 6

Hemicholinium-3 mechanism

Answer 6

Stops choline from entering the neuron (inhibits Na+/Choline transporter)

AcH can’t be synthesised

Anticholinergic

Question 7

Vesamicol mechanism

Answer 7

Inhibits H+/ACh antiporter meaning AcH can’t get into vesicle

Anticholinergic

Question 8

Muscarinic receptor type

Answer 8

G-protein coupled

Question 9

Nicotinic receptor type

Answer 9

Ligand-gated ion channel

Question 10

Muscarinic M1 Receptor location and response

Answer 10

Autonomic ganglia/CNS

Arousal, analgesia, late excitatory postsynaptic potential

Question 11

Muscarinic M2 receptor location and response

Answer 11

Heart

Decreased conductivity, conduction velocity and contractility

Question 12

Muscarinic M3 receptor location and response

Answer 12

Smooth muscle, contraction

Question 13

Muscarinic M4 location and response

Answer 13

CNS

Presynaptic autoreceptor. Feedback inhibittion to suppress ACh release

Question 14

Nicotinic Nm receptor location and response

Answer 14

Skeletal muscle neuromuscular junction

Depolarization and muscle contraction

Question 15

Nicotinc Nn receptor location response

Answer 15

Autonomic ganglia, adrenal medulla, CNS

Depolarization of postganglionic neuron, catecholamine secretion, arousal/attention/analgesia

Question 16

Ach is degraded by

Answer 16

AChE acetylcholinestarese

BuChE psyedocholinesterase

Question 17

Hexamethonium MOA

Answer 17

antagonizes AcH causing rapid tetanic fade

Question 18

Atropine MOA

Answer 18

antimuscarinic agent resulting in vagal blockade and subsequent tachycardia

Question 19

Methacholine MOA and use

Answer 19

Muscarinic receptor agonist… used to diagnose asthma and as a vagomemetic

Question 20

Reticular activating system

Answer 20

Cholinergic neurons that keep you awake

Benadryl make u sleeypy

Question 21

Pirenzipine use

Answer 21

Muscarinic M2/M3 blockade

Decreased GI motility for some reason

Question 22

Physostigmine MOA and use

Answer 22

AChE inhibitor

Used for anticholinergic overdoses

Question 23

Neostigmine MOA and use

Answer 23

AChE inhibitor

Used for GI motility, glaucoma

Question 24

Edrophonium MOA and use

Answer 24

Rapid and reversible AChE blocker

Used to diagnose myasthenia gravis

Question 25

Pralidoxime MOA

Answer 25

Binds to organophosphate deactivated AChE antidote

Question 26

Chronic myasthenia gravis treatments

Answer 26

long acting AChE inhibitors pyirdostigmine, neostigmine

Question 27

Why is physostigmine used for anticholinergic poisoning

Answer 27

CNS penetrance

Question 28

Drugs used for alzheimers

Answer 28

Donepezil, rivastigmine, galantamine

Question 29

Which alzeheimers drugs can also treat parkinsons

Answer 29

Rivastigmine

Question 30

Carbachol MOA and use

Answer 30

Muscarinic agonist used for glaucoma

Question 31

Bethanechol MOA and used

Answer 31

Muscarinic agonist. Used to promote GI/urinary motility

Question 32

Pilocarpine MOA and use

Answer 32

Miotic and saliva producing agent

Question 33

Cevilimine MOA and use

Answer 33

M1/M3 agonist for xerostomia in Sjörgen syndrome

Question 34

Succynicholine

Answer 34

THE S U C C depolarizing blockade of nicotinic receptors

Question 35

Scopalamine use and MOA

Answer 35

Muscarinic antagonist used for motion sickness

Question 36

Methscopolamine and glycopyrrolate

Answer 36

Quaternary amine antimuscarinics used to decrease GI spasms and oral secretions Glycoporrolate also prevents bradycardia (atropine pre medication style)

Question 37

Ipatropium MOA

Answer 37

Muscarinic antagonist

Question 38

Non depolarizing agents

Answer 38

Veccoronium Pancoronium Roccoronium

Question 39

Non depolarizing antidote MOA

Answer 39

Sugammadex forms complexes with vecc/rocc

Question 40

Benzotropine and Trihexyphenidyl MOA and use

Answer 40

M1 receptor antagonists. Balances dopamine with ACh Good for parkinsons

Question 41

Ipatroprium receptor

Answer 41

M3