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Flashcards in Biochemistry Deck (6)
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1

Leflunomide

Inhibits dihydroorotate dehydrogenase

Blocks conversion of carbamoyl phosphate to orotic acid

Pyrimidine synthesis step

2

Mycophenolate and Ribavirin

Inhibit IMP dehydrogenase

Blocks conversion of IMP to GMP

Purine synthesis step

3

Hydroxyurea

Inhibits ribonucleotide reductase

Blocks conversion of UDP to dUDP

Pyrimidine synthesis step

4

6-mercaptopurine and Azathioprine

Inhibit de novo synthesis of purine

Blocks conversion of PRPP to IMP

5

5-FU

Inhibits thymidylate synthase which decreases deoxythymidine monophosphate (dTMP) because blocks conversion of dUMP to dTMP

Pyrimidine synthesis step

6

Methotrexate (MTX), Trimethoprim (TMP), and Pyrimethamine

Inhibits dihydrofolate reductase

Meds in order: in humans, bacteria, and protozoa

Blocks conversion of DHF to THF

Pyrimidine synthesis step