Biochemistry Medications Flashcards Preview

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Flashcards in Biochemistry Medications Deck (19):
1

phlorizin

inhibits SGLT2

reduces blood glucose levels

type II diabetes med

2

omeprazole (prilosec)

inhibits H/K ATPase

gastric reflux

3

sulfonylurea drugs

closes ATP gated K channel in pancreatic beta cells

type II diabetes

increases insulin release

4

diazoxide

opens ATP K channels in beta cells

blocks insulin secretion....treats hyperinsulinemia

5

zidovudine (ZDV) and azidothymidine (AZT)

nucleoside analog of deoxythymidine
- Reverse transcription inhibitor

block further DNA syn since no 3'-OH group

RT = higher affinity for these than our own DNA polymerases

6

2,3 dideoxyinosine (DDI)

2' and 3' carbons --> chain terminatoin

HIV

7

acyclovir (HSV)

ganecyclovir

guanosine analogs

phosphorylated in infected cells

inhibit DNA synthesis

8

5FU

analog of thymidine and uracil

F-dUMP binds and inhibits thymidine synthetase

dUMP can't be converted to dTTP

cancer drug

9

allopurinol

suicide inhibitor of xanthine oxidase

treates gout

increases hypoxanthine and xanthine levels (more soluble than uric acid)

10

antabuse

inihibts acetaldehyde dehydrogenase

increases acetaldehyde --> hangover symptoms

11

methotrexate

BH4 analog

prevents formation of BH4

cancer treatment

12

rifampicin

inhibits initiation of prokaryotic RNA synthesis

treats tuberculosis

13

ciprofloxacin

inhibits bacterial topoisomerase

14

irinotecan

topotecan

type I topoisomerase inhibitors

treats colorectal and ovarian cancers

15

doxorubicin

etoposide

ellipiticine

type II topoisomerase inhibitors

16

cisplatin

cause DNA adduction to trigger apoptosis

17

statins

inhibit HMG-CoA reductase

upregulation of LDL receptor --> reduction of blood cholesterol levels

not helpful with people with dysfunctional LDL receptors

18

bile acid sequestrants

decrease bile acid reabsorption in intestines

more cholesterol has to be converted to bile acids for digestion

19

fibrates

reduce TG levels by activating transcription factor PPARalpha

can cause gall stones