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Flashcards in Neurophysiology Deck (26):
1

alpha1 receptors

adrenergic

location = SmM of skin and splanchnic regions, GI, bladder sphincteres, and radial muscles of iris

produces excitation = contraction or constriction

NE and Epi (think NE)

Mechanism:
Gq protein --> phospholipase C --> (+) IP3 and Ca2+

2

alpha 2 receptors

adrenergic

location = presynaptic nerve terminal of walls of GI tract

produces inhibition = relaxation and dilation

NE and Epi

Mechanism:
Gi protein --> (-) adenylate cyclase --> (-) cAMP

3

beta 1 receptors

adrenergic

SA node, AV node, and ventricular heart muscle

produce excitation = increased heart rate, increased conduction velocity, and increased contractility

(+) = both NE and Epi (more sensitive than alpha1 receptors!!)

(-) = propanolol

Mechanism:
Gs protein --> stimulation of adenylate cyclase --> cAMP

4

beta 2 receptors

adrenergic

SmM of bronchials, and walls of GI and bladder

produces relaxation

more sensitive to Epi thanNE

more sensitive to Epi than alpha1 receptors

(-) propanolol

Mecanism (same as beta1):
Gs protein --> stimulation of adenylate cyclase --> cAMP

5

Parasympathetic signal pathway

CNS --> long preganglionic --> release ACh

ACh stimulates nicotinic receptor --> postganglionic neuron (+)

release ACh to effective organ --> (+) muscarinic receptor

6

Sympathetic signal pathway

CNS --> short preganglionic --> release ACh

ACh stimulates nicotinic receptor --> postganglionci neuron (+)

release NE (mostly) --> (+) alpha1,2 or beta1,2

7

adrenal stimulation signal pathway

preganglionic neuron release ACh

ACh stimulates nicotinic receptor on adrenal galdn --> (+) mostly epi than NE

8

Pacinian corpuscle

onion like sructures in the subcutaneous skin (surrounding unmyelinated nerve endings)

vibration, tapping

rapidly adapting

9

Meissner's corpuscle

present in non hairy skin

velocity sensation encoded

rapidly adapting

10

Merkel's disk

transducer in on epithelial cells

location sensation encoded

slowly adapting

11

which autonomic receptor is blocked by hexamethonium at the ganglia....but not at the neuromuscular junction

cholinergic nicotinic receptors

12

Prazosin (medication to lower high bp)

mechanism =?

inhibition of alpha-1 receptors on vascular SmM

prevents constriction

13

which is mediated by parasympathetic stimulation?

dilation of bronchiolar SmM

erection

ejaculation

constriction of GI sphincters

increased cardiac contractility

erection

14

which autonomic receptor mediates increased heart rate

adrenergic beta 1

15

what drugs would you give to an asthma patient

beta2 agonists
- albuterol
- epinephrine (to lesser extent NE)

16

what drugs would you NOT give an asthma

beta2 antagonists
- propanaolol

17

which autonomic receptors stimulate adenylate cyclase

beta 1 and 2

18

NE = what kind of agonist

beta 1

19

atropine = what kind of antagonist

muscarinic cholinergic antagonist

20

clonidine

alpha 2 agonist

21

curare

nicotinic cholinergic antagonist

22

propanolol

beta 1 and 2 antagonist

23

receptor that mediates release of epinephrine from adrenal medulla

ACh nicotinic

24

which autonomic receptor is stimulated by low levels of epinephrine released from adrenal medulla

beta 2 receptors

more sensitive than alpha 1

25

autonomic recpetor that (+) IP3/Ca2+

alpha 1

26

autonomic receptor that (-) adenylate cyclase

alpha 2