Biology of Cancer Flashcards
DNA damage is not a mutation until when?
HNPCC is due to what type of DNA defect?
Ataxia telangiectasia is due to what type of DNA defect?
ATM gene - DNA damage recognition
BRCA-1,2 (predisposition to breast cancer) is due to what kind of DNA defect?
repair by homologous recombination
Xeroderma pigmentosum is due to what kind of DNA defect?
Nucelotide excision repair (NER)
These cells are anchor independent, resistant to senescence, and resistant to apoptosis
This results from gain of function mutations of a growth promoting gene
Normal genes that encode growth-inhibiting products that show loss of function in cancer cells
Tumor suppressor genes
c-onc refers to
Ras stimulates what pathway, which in turn activates transcription?
MAP kinase cascade
When Ras remains activated, how does this effect the cell cycle?
Mitosis is activated and remains activated
What is bound to Ras to activate it?
What is the tumor suppressor that is responsible for turning off the Ras complex?
Rb binds to what protein to arrest the cell cycle from inappropriate proliferation?
Tumor Suppressor Gene for Retinoblastoma