Biopsycology Flashcards

(49 cards)

1
Q

A01-plasticity and functional recovery- plasticity

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Refers to the ability of our brain to adapt its structures/ functions as a result of our life experiences
- if a new task is learned a new pathway is formed, if this pathway is repeated/ used they are strengthened
- if the pathway is not used its weakened and the connections are deleted this is known as synaptic pruning
- research suggests that the brain continue to create new neural pathways and alter existing ones in response to changing experiences

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2
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AO1 plasticity and functional recovery- functional recovery

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-an important part of neural plasticity
-involves ability of the brain to recover loss of function after brain damage
- its the transfer of functions from a damaged area of the brain after trauma or physical damage to other undamaged areas
-the brain can reorganise itself by forming new synaptic connections
-secondary neural pathways are activated ‘unmasked’ to enable functioning to continue and recovering any damage that has occurred in a specific region.

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3
Q

A03- brain plasticity and functioning- supporting evidence for platisicity

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  • supporting evidence to support plasticity come form McGuire et al, she studied brains if London taxi drivers and found they has significantly higher volume of grey matter in the posterior hippocampus than a control group
    -part if a taxi drivers training is to improve spatial and navigational skills and are tested on this
  • this is a strength as the results from this study show that this learning alters the structure of their brains supporting brain plasticity
    -additionally this can be useful in real work application
    -perhaps companies can be aware when their drivers knowledge needs to be trained again by looking at brain scans to optimise taxi performance
    -however sample was androcentric
    -doesn’t include women
    -there are likely t be femal taxi drivers and the females navigational skills may be different to males
  • weakness as conclusions cannot be genralised to total population and can’t generalise to all cultures so culture bias.
    -but does give general idea f how brain plasticity works
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4
Q

A03- brain plasticity and functional recovery- application -strength

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-real life application
Understanding the processes of plasticity and functional recovery led to the development of neurorehabilitation which uses motor therapy and electrical stimulation of the brain to counter the negative effects and deficits in motor and cognitive functions following accidents, injuries and/or strokes. This demonstrates the positive application of research in this area to help improve the cognitive functions of people suffering from injuries.

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5
Q

-A03 functional recovery and plasticity - FR —strength FR supporting research

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  • Gaby Giffords was shot in the left hemisphere and place in a coma so her brain could recover
    -within months + some rehabilitation she could walk and regard control of left arm/leg
    -could read, understand and speak in short phrases
    -an now has some control over her right arm/leg
    Which is controlled by the left hemisphere so should be impossible
    -strength as fit gives support for functional recovery
    -however not very generalisable and also has economic implications as people with brain damage can potentially go back to work and contribute again
    -only one idographic case so can’t assume same succesful recovery os everyone else
    -also was a female so can’t assume males will ave the same level of functional recovery
    So weakness as its ungenralisable.
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6
Q

A01 split brain research + Lateralisation

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-based on concept of of hemispheric lateralisation which is the idea that the two hemispheres of the bran have different specialisations , they are not entirely the same
-sperrin and Gazzaniga were the first to investigate this with the use of split brain patients
- this is a procedure where the corpus callosum which connects the two hemispheres is cut,
-the aim of their research was to examine the extent to which the two hemispheres are specialised for certain functions
-findings hilights a number of differences between the two hemispheres
-left is dominant in terms of speech and right is dominant of visual and motor tasks.

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7
Q

A01 -split brain and lateralisation -procedure

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  • Sperry (1968) sought to demonstrate that the 2 hemispheres were specialised to certain functions
    -normally concrete by corpus callosum yet sperry studied a group of people who had theirs cut to control epileptic procedures . A commissurtomy.
  • an image or word was projected to a patients left hemisphere and another image to the right
    -in a Normal brain the corpus calllosum shares info between both hemispheres
    -in split brain the info cannot be converges from the chosen hemi to the other
    -other experiments were used such as deceive what they we and a drawing task and the ps has to respond with either their right hand, left hand or verbally
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8
Q

A01 split brain research and lateralisation - finings

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-when asked to describe the picture presented to the right visual field the patient could derscribe what they saw
-demonstrating superiority of the left hemisphere when it comes to language
-whereas when patient had to describe the picture presented to the left visual fiend they could not and often reported that there was s nothing there -
- however patainets could draw the image what their left had as the task does not require language
-sperry concluded that the left hemisphere is dominant for speech and language while the right hemisphere is specialises for visual spatial motor skills

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9
Q

A03- split brain and lateralisation — weakness generalisation

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  • many researches have said these finding cannot be genralised to the wider population or widely accepted as split brain patients are such an unusual unique sample of people
    -only 11 patients took part in all variations and all had history of seizures
    -this may have caused unique changes in the brain that influences the findings
    -limitation as it lilies the extent to which the findings can be genralised to normal brains therefore reducing its validity
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10
Q

A03- split brain and lateralisation— strength application

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-supporting evidence comes from rogers et al who studies chickens

It is assumed that the main advantage of brain lateralisation is that it increases neural processing capacity (the ability to perform multiple tasks simultaneously). Rogers et al. (2004) found that in a domestic chicken, brain lateralisation is associated with an enhanced ability to perform two tasks simultaneously (finding food and being vigilant for predators). Using only one hemisphere to engage in a task leaves the other hemisphere free to engage in other functions. This provides evidence for the advantages of brain lateralisation and demonstrates how it can enhance brain efficiency in cognitive tasks.

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11
Q

A03- split brain and lateralisation— strength methodology

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-sperry carefully standardised the procedure of presenting visual info to one hemisphere field at a time which was quite ingenuous
-the image flashed on front of the patients eye for 0.1 seconds so the patient hd no Time to move their eyes over the image and spread info across both sides of the visual field or both sides of the brain
- this allowed sperry to vary aspects of the basic procedure and ensure only one hemisphere received the info at a time
-therefore a strength as it was a well controlled procedure so has high internal validity

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12
Q

A01 localisation - motor and what

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-refers to the belief that specific areas of the brain are responsible for particular psychical and psychological functions
-motor area located at back of the frontal lobe, responsible for voluntary movement sending signals to the muscles
-right hemisphere controls left side of body and left hemisphere controls right

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13
Q

A01 localisation- brocas and somatosensory

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-brocas -located in the left frontal lobe and involved its speech production
-if damaged (brocas aphasia) a persons speech is slow and lacks fluency
The Broca’s area is named after Paul Broca, who discovered this region while treating a patient named Leborgne, who was more commonly referred to as ‘Tan’. Tan could understand spoken language but was unable to produce any coherent words, and could only say ‘Tan’.
Tan could understand spoken language but was unable to produce any coherent words, and could only say ‘Tan’. After Tan’s death, Broca conducted a post-mortem examination on Tan’s brain and discovered that he had a lesion in the left frontal lobe. This led Broca to conclude that this area was responsible for speech production. People with damage to this area experience Broca’s aphasia, which results in slow and inarticulate speech

-somatosensory-, located at the front of the parietal lobe
-receives sensory info from skin to produces sensations related to pressure, temp and pain

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14
Q

A01 localisation- visual and auditory

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  • visual area-back of occipital lobe
    -receives and processes visual info
    -damage to left visual area can produce blindness in the right visual field and vice versa
  • auditory- temporal lobe
    -responsible for analysing and processing acoustic information
    -info from left ear goes to right hemisphere and vice versa
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15
Q

A03-localisation - strength- supporting evidence

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-phineas gage
- experienced huge changes to his personality when a iron rod was blasted through his frontal lobe
- before acccident he was kind, calm ,reserved and after he was rude hostile and quick tempered
-demonstrates that there are localised areas of the brain as the area gage damaged links to reasoning control and mood.

-however this was a unique case study therefore we cannot generalise to the rest of the population and slo difficult to replicate so lowers the validity of the study

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16
Q

A03-localisation- Karl lashelys research weakness

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-removed 10-50% of cortexes in rats learning a maze
-when tested no specific area proved to be more important
-this suggests that learning is too complex to be localised and requires involvement of the whole brain
-so shows that higher cognitive functions like learning aren’t localised and is distributed in a more holistic way

-however this was an animal study, rats have different physiology than humans so can’t be accurately related to humans so can’t generalise to humans also could be classed as unethical and he removed rats brains which may have harmed them

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17
Q

A03-localisation- Lashley equipotenitality theory weakness

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However, although there is evidence from case studies to support the function of the Broca’s area and Wernicke’s area, more recent research has provided contradictory evidence. Dronkers et al. (2007) conducted an MRI scan on Tan’s brain, to try to confirm Broca’s findings. Although there was a lesion found in Broca’s area, they also found evidence to suggest other areas may have contributed to the failure in speech production. These results suggest that the Broca’s area may not be the only region responsible for speech production and the deficits found in patients with Broca’s aphasia could be the result of damage to other neighbouring regions.

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18
Q

A01-circadian rhythms- endogenous pacemakers

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-circadian rhythms last around 24 hours and are controlled by an endogenous pacemaker
-main one os suprachiasmatic nucleus (SCN} in the sleep wake cycle
- lack of light activates the SCN to send signals to the pineal glad to release melatonin which in turn inhibits paragon mechanisms which promote wakefulness and onset of sleep is triggered
-two divisions of SCN, ventral and dorsal.
- albus et al found that he ventral SCN is quickly reset by external cues whereas dorsal SCN is much less affected and more resistant to to being reset

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19
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A01-circadian rhythms- Siffre

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-demonstrated there is a fire running circadian rhythm
- stayed underground for extebed periods of time with no external cues to guide his rhythms ( no clock or day light)
- after spending 6 months in a cave his circadian rhythm settled to just over 24 hours
- indicates the roll of endogenous pacemaker in control of circadian rhythms

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20
Q

A01-circadian rhythms- core body temp

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  • core body temp best indicator or cocadian rhythm
  • lowest around 4;30 am ( 36) and highest around 6 pm (38)
    -cooler temp signals for reduced activity ( sleeping)
    And higher temp for increase acitivity
  • core body temp has been linked with cognitive ability
    -demonstrated by folkard et al where children who had stroke read to them at 3 pm (higher body temp ) showed superior recall and comprehension of the story retaining 8% more meaningful material than children read to at 9 am (lower core temp)
21
Q

A03- circadian rhythms- weakness siffre

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-was a case stidy meaning the findings are unique to him as his body’s behaviour may nit be typical of all people
-issue as the finding can not be generalised to the wider population as he is not representive
-moreover siffre noticed at the age OG 6- his internal clock ran slower than when he was a young man showing that individuals of different ges have unique circadian rhythms this limiting the external validity of the study
- however study had. High level of control ,(exigenous zeitgebers) in order to observe effects on circadian rhythms
-this means its possible to draw a casual relationship

22
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A03- circadian rhythms - strength practical application

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  • Bevin et al found that night workers who engaged in shift work experience a period of reduces concentration around 6 in the morning meaning mistakes and accidents are most likely to happen
  • research is useful to employers as it shows them when productivity is lowest and when incidents are most likely to take place so they could try and avoid them
    -thus research into the sleep wake cycle may have economic implication in terms of how to manage worker productivity
23
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A03- circadian rhythms- weakness - Duffy et al

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-important to note differences between indivials when it comes to circadian rhythms
- Duffy et al found that ‘morning people’ prefer to rise and go to bed early whereas ‘evening people’ prefer to get up anf go to bed late
-this demonstrate that there may be innate individual differences in circadian rhythms which suggests researchers should focus on these differences during investigations

24
Q

Endo and exo AO1- endo

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Endogenous- internal bodily regulators of bio rhythms or affecting such biological rhythms to conform to certain cyclical periods
Superchiasmatic nucleus receives info about day length from eyes where this info has beeen processed by the ocupital lobe and relayed to SCN via the optic chiasm
- SCN processes info and triggers the pineal gland to release different rates off melatonin
- increased melatonin triggers decreased serotonin production creating feelings of sleepiness and durning night the opposite
-

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Exo and endo- a01 - exo
Exogenous- external environmental changes affecting biological rhythms to conform to certain cynical time periods Social cues-are examples which entrain bio rhythms these include set meal and bed times which signify when to wake up and fall asleep This means in order to avoid jet lag it’s useful to accustom yourself too the set sleeping and eating times of your destination to avoid desynchronisation
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Endo and exo AO3- strength case study
- the effect of SCN was demonstrated by decoursey et al who surgically lesioned the SCNs of 30 chipmunks and compared their circadian rhythms in their natural habitat with 17 controls - researchers found that the vast majority of the experimental group had been killed in the first 80 days after being returned and episodes of nocturnal movement were detected within their permanent dens -this is a strength as it shows that the SCN establishes and maintains the sleep wake cycle -however difficult to generalise as its generalising from animals to humans which i hard to do as the physiology is different - moreover there’s ethical issues as the animals were exposed to much harm and risk so undermining its credibility
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Endo and exo AO3- strength case study exo
This was demonstrated and supported by siffre et al who stayed in a cave for 2 months with no exogenous z like light or a clock and his sleep wake cycle free ran to around 25-30 hours displaying how exogenous have influence over circadian rhythms Also was demonstrated by Campbell and Murphy who found that shining light on the back of ps knees shifted circadian rhythms which is a strength as its showing evidence light doesn’t need to be detected in they eyes to affect bio rhythms
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Endo and exo A03- confounding research exo
Miles (1977) recount the story of a blind man, who had been blind from birth and had a circadian rhythm of 24.9 hours. Despite being exposed to social cues his sleep/wake cycle could not change and needed sedatives at night and stimulants in the morning. Alongside this in artic regions people show normal sleep patterns despite prolonged exposure to light. Both suggest that there are occasions where exogenous zeitgebers have little bearing on our internal rhythm.
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Fight or flight- a01
-The fight or flight response becomes activated when an individual enters a stressful or dangerous situation -It is an evolved survival method that lets humans and other animals react quickly to life-threatening situations -1 the responses to the sensory impact for example what we hear see and smell -2They connect the century input with emotions associated with the fight of flight response for example fear and anger -3 If the situation is deemed stressful or dangerous, they make less sense a distress signal to the hypothalamus -4 this communicates with the body through the sympathetic nervous system -5 The SNS stimulates the adrenal medulla to secrete the hormones, adrenaline, and adrenaline into the bloodstream 6-Adrenaline can cause a number of psychological changes to prepare the body to fight or fly -Following the response, the parasympathetic nervous system is activated to return the body back to its normal resting state -The parasympathetic nervous system will slow down our heart rate and breathing rate and reduce our blood pressure -In the sympathetic nervous system, they can be many psychological changes for example increased heart rate to increase blood flow to organs, increase breathing rate to increase oxygen intake, pupil dilation to increase entry into the eye, sweat production to regulate temperature, and reduction of non-essential functions like the digestive system or salvation to increase energy for other essential functions
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Fight or flight- a03
One weakness is lots of early research into this response is typically conducted on males so his androcentric -Consequently many researchers assumed that the findings could be generalised to females -Many research finds that females can adopt a tend and befriend response to stressful and dangerous situations -Taylor found that women are more likely to protect their offspring (tend) -Or from alliances with other women (their friend) -Rather than fight an adversary or flea -Furthermore, the fight or flight response may be counterintuitive for women -As running might be seen as a sign of weakness and put their offspring at risk of danger -Therefore the research done into fight your flight highlights of beta bias. A psychologist assumed that females responded in the same way as males until Taylor provided evidence of a tend and befriend response
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Fight or flight- a03
-Another criticism would be that some psychologists would say that we have a freeze response -So Gary argued that we avoid confrontation and that prior to responding with attacking over running away most animals display the freeze or stop to look and listen response -Where the animal is hyper vigilant and alert to the slightest sign of danger -The adaptive advantages of this for humans is that freezing focuses our attention and makes them look for new information in order to make the best response for that particular threat -therefore, a weakness as It therefore doesn’t count for the whole story of fight or flight
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Fight or flight- a03
-there is evidence for positive behaviour rather than fight or flight behaviour -von dawans challenges of view that under distress men respond only with fight or flight -Whereas women are more prone to tend and be friend -It was found that acute stress can actually lead to greater cooperative and friendly behaviour even in men -This could explain the human connection that happened during term of crisis such as the 911 terrorist attack attacks -One reason for this maybe because human beings are fundamentally social animals and is the protective nature of human social relationships that has allowed our species to thrive
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Ultra/infra rhythms A01- infra
-infradian rhythms are those that take longer than 24 hours to complete -An example of this would be the menstrual cycle which is governed by monthly changes in hormone levels -A typical cycle lasts 28 days -During each cycle rising levels of oestrogen cause the ovary to release an egg -And after ovulation the hormone progesterone helps the womb lining to grow thicker -Ready in the womb for pregnancy -if pregnancy does not occur, the egg is absorbed into the body and the womb lining leaves the body -Seasonal affective disorder is also another example -And this is depression that caused during the winter and recovery is experienced in the summer -this is thought to be that the hormones serotonin is released less due to the dark winter months -research was conducted by Russell who studied 29 women with irregular periods -Samples of pheromones were gathered from none of the women are different stages of their menstrual cycle Kels -Via cotton pad placed in their armpits -The parts were rubbed on the upper lip of the participants -They found that 68% of women experience change to the cycle which brought them closer to the cycle of their older donor -suggesting the menstrual cycle is affected by pheromones which is an exogenous factor
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Ultra/infra rhythms A01 ultra
Ultraradian are rhythms that last less than 24 hours -An example would be blinking heartbeats sleep cycle and digestion -One big one is the sleep cycle -We go through five distinct stages which span about 90 minutes -It starts at light sleep progressing to deep sleep and then rem sleep -stage 1: this is light sleep you are easily woken up, Alpha brain waves occur -stage 2: light sleep continues, sleep spindles which are shortness of activity occasionally occur -stage 3 + 4 : There is deep sleep or slow wave sleep, Delta waves occur with lower frequencies, difficult to wake someone up at this point -stage 5 : Sleep, The body is paralysed yet brain activity closely resembles that of the awake brain, the brain produces feet of waves and the eyes move around and dreams are most often experienced during RAM sleep
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Ultra/infra rhythms A01 ultra research
-an assumption of research into the sleep cycle is that during REM sleep dreaming takes place - dement and Kleitman recorded the sleep patterns of nine participants in a sleep lab on an EEG -And controlled the effects of caffeine and alcohol -they were studied under controlled labs conditions and reported to the lab shortly before their usual bedtime -They were asked to abstain from alcohol and caffeine during the time period of the study -They went to bed in a dark room and observed over a number of nights with an EEG sensor attached to their head to measure brain and eye activity -They were randomly awoken a number of times per night using a doorbell sound -They were unaware if they had been awoken during NREM or REM sleep I will ask to record the content of their dreams if they had any into a nearby voice recorder -In the participants the REM sleep could last between three and 50 minutes but overall 20 -The participants experienced a period of RAM sleep every 92 minutes on average -And they all experienced REM sleep every night -80% of the time when they were walking during sleep, they reported a clear dream -However when awoken during NRM sleep only 7% recall having a dream -They show their dream rec recall is more frequent when waking up in REM sleep -and REM sleep is clearly linked with dreaming 
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Ultra/infra rhythms- ultra A03
-A strength of studying ultra radiant rhythms is a supporting evidence for the distinct stages of sleep comes from highly controlled lab studies -for instance dement and kleitman recorded the sleep patterns of nine participants in a sleep lab on an EEG and they control the effects of caffeine and alcohol -Using these methods allowed for high control of extraneous variables -Therefore increasing the validity as research is a more certain that the results obtained with due to the independent variable -Allowing us a concrete cause-and-effect relationship to be established -Additionally, the lab experiments used standardised practices and these can be tested for replicability and consistency -therefore, due to the methodological practices implemented it allows for objective and empirical evidence to be collected and a high internal validity 
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Ultra/infra rhythms ultra A03
-however a limitation is the research is done in a lab setting which is unrealistic to normal circumstances -Well investigating sleep patterns they subjected participants to a specific level of control and use EEG to measure such rhythms -So participants were attached to monitors in a sleep lab -Therefore arising methodological issues when assessing the effects of caffeine and alcohol as firstly they were in a lab environment unfamiliar to them -Which may have affected their natural sleep -And the EEG is attached to their scalps Also add an unrealistic setting which participants had to sleep in -Therefore, it reduces the ecological validity of the study and questions the generalisability of findings outside the research setting -therefore limiting its explanatory power 
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Ultra/infra rhythms - ultra A03
A weakness with studying the sleep cycle Kels is the difference is observed in people which make investigating patterns very difficult -tucker found significant differences between participants in terms of duration of each stage -Particularly stages three and four -this demonstrates that there may be an individual differences in trading rhythms which means that it is worth focusing on these differences during investigations into sleep cycles 
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Ultra/infra rhythms A03 infra
-research into the menstrual cycle is supported by the theory of evolution -For example, it may have been advantageous for women to men together and become pregnant at the same time -In social groups this would allow babies to have lost their mothers during childbirth to have access to breastmilk thereby improving the chances of survival -suggesting that the synchronisation of the menstrual cycle is an adaptive strategy 
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Ultra/infra rhythms A03 infra
-there is research to suggest that infradian rhythms such as the menstrual cycle are also important regulators for behaviour - Penton volk et al -Found that women expressed a preference for feminised faces at the least fertile stage of their menstrual cycle and from a masculine face at the most fertile point -these findings indicate that women sexual behaviour is motivated by their infra rhythms highlighting the importance of studying infra rhythms in relation to human behaviour 
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Ultra/infra rhythms A03
There is more research to suggest the menstrual cycle is to some extent governed by exogenous zeitgerbers - Reinberg examined a woman who spent three months in a cave with only a small lamp to provide light -He noticed that her mental cycle shortened from the usual 28 days to 2 5.7 days -The suggested that the lack of light in the cave has affected her mental cycle and therefore demonstrating the effect of external factors of infra rhythms 
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Brain scans ao1
So study the brain allows psychologist to investigate localisation of the brain and look at what part of the brain is responsible for different functions -Functional magnetic resonance imaging or FMRI -Works by detecting the changes in blood flow and blood oxygenation that occur as a result of neural activity -When a part of the brain is more active more blood is consumed to meet the demand of the increased activity -To meet this demand blood flow is directed towards the area -This is a haemodynamic response -The image produced is three dimensional showing which parts of the brain are involved in different mental processes
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Brain scans ao1
-electroencephalogram or EEG -Measures electrical activity within the brain the electrodes on a skull cap - The sky represents brain waves that are generated from the action of thousands of neurons -By measuring characteristic wave patterns the EEG can help to diagnose certain conditions of the brain -Event related potentials ERP’s -Is what’s left after a statistical averaging technique and is used to fill out all the extra extraneous brain activity from the original EEG recording and only leaving response related to the specific response
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Brain scans ao1
Post-mortem examination is a technique involving the analysis of a persons brain following their death -they are used to determine whether the behaviour is observed during a persons lifetime or linked to structural abnormalities in their brain 
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Brain scans ao3 FMRI
A strength of FMRis is unlike standing techniques like PET scans it does not rely on the use of radiation -It is also straightforward to use and risk free additionally non-invasive -However F MRIs are very expensive in comparison to other neuro imaging techniques -And has poor temporary resolution with a delay of around five seconds -Meaning the FMRI may not represent moment to moment brain activity
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Brain scans A03 eeg
-One strength of EGS is it has been useful in studying the stages of sleep and the diagnosis of conditions such as epilepsy -It has high temple resolution -And today the technology can detect brain activity our resolution of 1 ms which shows a real world usefulness -However they only provide a measure of general brain activity -Meaning the brain responds to a single stimulus or event of interest is not usually visible in an EEG -however, it is possible to tease out and isolate specific sensory cooperative and motor responses with EEG data 
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Brain scans ao3 eeg and erps
E.g.’s and ERP’s are less invasive than other scanning techniques such as PET scans -For example, they don’t use radiation or require instruments to be inserted in the brain -So they are virtually risk free -In addition they are cheaper methods compare to F MRIs and therefore more widely available to researchers -However a major disadvantage is they have poor spatial resolution -They only detect the activity in superficial regions of the brain -They are unable to Provide information on what is happening in the deeper regions of the brain like the hypothalamus making this technique limited in comparison to the FMRI which is a spatial resolution of one to 2 mm
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Brain scans ao3 post mortem
-One strength of a post-mortem is they were vital in the foundation for early understanding of key processes in the brain -Additionally they provided detailed examination of structure of the brain that is not possible with other scanning techniques -They can access areas such as the hypothalamus and hippocampus which other scanning techniques would struggle to reach -This matters because postmortal examinations provide research researchers with an insight into these deeper brain regions -Which often provide a useful basis for further research -Limitation however is the observed damage in the brain may not be directly linked to the behaviours or disorders in question -We cannot determine causation -In addition to this there are many ethical issues in relation to informed consent -many post-mortem examinations are carried out on patients with severe psychological deficits for example patient HM who suffered from severe amnesia -These participants would not be able to provide fully informed consent and yet a postal examination has been conducted on his brain -Therefore this is a severe ethical questioning surrounding the nature of such investigations
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Brain scans ao3
-what are the main limitations? However of post-mortem is the issue of causation? -The deficit of patient displays during their lifetime like an inability to speak may not be linked to the deficits found in the brain like a damaged Broca’s area - These deficits reported could’ve been a result of other illnesses and therefore psychologist are unable to conclude that the deficit is caused by the damage found in the brain -All the confounding factors, including medication a person may have been taking throughout their lives or the length of time between death and post-mortem at the age of a person’s death