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Biochem > Biosynthesis of nucleotides > Flashcards

Biosynthesis of nucleotides Flashcards

1
Q

Important name in nucletoides? scientist..

A

John Buchanan

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2
Q

What is the difference between purines and pyrimidines?

A

Purine= 2 carbon nitrogen rings

pyrimidines: 1 carbon 1 nitrogen ring

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3
Q

What are the purines?

A

Adenine

Guanine

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4
Q

What are the pyrimidines?

A

Cytosine
Thymine
Uracil

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5
Q

What are the 2 pathways of nucleotide synthesis?

A
  • De novo : using metabolic precursors (a.a. , ribose-5-phosphate, CO2, NH3)
  • Salvage pathway: using purine and pyrimidines bases released from degration of nucleotides
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6
Q

What is the difference between nucleotide, nucleoside, and nitrogenous bases?

A

Nitrogenous bases: purine or pyrimidine
Nucleoside: pentose sugar + nitrogenous ring
Nucleotide: phosphate group: pentose sugar+ nitrogenous base

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7
Q

What is the bond between the nucleotides? Between what and what carbon?

A

Phosphodiester bond

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8
Q

Can purine and pyrimide be synthesized as independant molecules?

A

no! They are always part of a nucleotide

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9
Q

What are purines build on?

A

Ribose phosphate

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10
Q

What are pyrimidines build on?

A

OROTATE, and than attached to RIBOSE PHOSPHATe

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11
Q

What is one precursor but also intermediate in many pathways of a.a. and nucleotide synthesis?

A

5-phosphoribosyl 1-pyrophosphate (PRPP)

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12
Q

what is the a.a. precursor for purines?

A

GLycine

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13
Q

What is the a.a. precurosr for pyrimidines?

A

Aspartate

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14
Q

Aller voir les slides pour de novo synthesis of purines

A

GO

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15
Q

What type of inhibition is the regulation of novo synthesis of purines?

A

Feedback inhibition

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16
Q

What are the 2 phases in pentose phosphate pathway?

A

Oxidative and non-oxidative phase

17
Q

What is the main enzyme that participate in the conversion of ribonucleotides to deoxyribonucleotides

A

Ribonucleotide reductase

18
Q

Aller voir la page sur conversion de ribonucletodie to deoxyribonucleotide

A

GO

19
Q

What does the non-oxidative phase of pentose phosphate pathway does?

A

It regenerates G-6-P from ribulose-5-phosphate

20
Q

What does PRPP do in novo synthesis of purines and pyrimidines?

A

It brings in the ribose!

Biochem (8 decks)

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