Biothérapies/thérapies ciblées Flashcards

1
Q

V/F: Les Ac monoclonaux sont dirigés contre le même épitope

A

Vrai

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2
Q

Ac anti-CD20: humain, murin, murin humanisé ou chimérique? (rituximab)

A

chimérique

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3
Q

Quel est le risque de la 1ère cure de Rituximab?

A

syndrome de relargage cytokinique

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4
Q

Donner les 2 hémopathies et l’autre type d’indication du rituximab

A

LLC, lymphome B

maladies auto-immunes

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5
Q

Ac anti-CD52 (alemtuzumab): humain, murin, murin humanisé ou chimérique?

A

murin humanisé

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6
Q

Quel est le risque de la 1ère cure d’alemtuzumab?

A

sd de relargage de cytokines

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7
Q

Quel est le petit nom de l’Herceptine?

A

Trastuzumab, c’est un Ac humanisé

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8
Q

Contre quoi est dirigé le Devacizumab (Avastin)?

A

VEGF: c’est un anti-angiogénique

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9
Q

Anti-TNF alpha: Protéines de fusion ou anticorps? Embrel

A

Protéine de fusion. Embrel

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10
Q

Anti-TNF alpha: Protéines de fusion ou anticorps? Remicade R

A

anticorps monoclonal chimérique: infliximab

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11
Q

Anti-TNF alpha: Protéines de fusion ou anticorps? Humira

A

anticorps monoclonal humain: adalimumab

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12
Q

A quelle classe apparitennent le certolizumab Cemzia et le golimumab Simponi?

A

anti-TNF alpha

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