Bladder Disorders & Urinary Incontinence Flashcards

(79 cards)

1
Q

Signs of Glomerular Bleeding

A

Red cell casts: glomerulonephritis
Dysmorphic RBCs
Proteinuria with hematuria with a large percentage being albumin

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2
Q

Etiologies for Non-glomerular Hematuria

A
UTI: acute cystitis, pyelonephritis
Kidney trauma
Stones: calyx, ureter
Contamination at menstruation or postpartum
Fistula
Endometriosis
BPH
Vigorous exercise
Post strep glomerular nephritis
IG nephropathy
Cancer: over 40
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3
Q

Risk Factors for Malignancy

A
Age: 35+
Smoking history
Occupational exposure to chemicals/dyes
Hx of gross hematuria
Hx of chronic cystitis or irritative voiding symptoms
Hx of pelvic irradiation
Exposure to cyclophosphamide
Hx of chronic indwelling FB
Hx of analgesic abuse
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4
Q

Hematuria Work-Up

A

Urine culture
Urine cytology
Imaging: CT IVP, US (pregnant women)
Cystoscopy

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5
Q

Negative Work-up of Hematuria in Young & Middle-age Patients

A

Mild glomerular disease

Predisposition to stone disease

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6
Q

Negative Work-up of Hematuria in Patients at High Risk for Malignancy

A

Need annual UA

May need another work-up in 1-3 years

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7
Q

Monitoring for Mild Glomerular Disease

A

BP: every 6 months
GFR/CrCl: yearly
Proteinuria: yearly

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8
Q

Reasons for Cystitis

A

UTI
Pyelonephritis
Non-infectious
STI-Male

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9
Q

Pathogenesis of Cystitis

A

Colonization of the vaginal introits from fecal flora
Ascension to the bladder via the urethra
Can ascend to the kidneys (pyelonephritis)

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10
Q

Most Common Pathogens in Microbiology

A

E. coli (75-90%)
Proteus
Klebsiella

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11
Q

Clinical Presentation of UTI

A
Dysuria
Frequency
Urgency
Suprapubic pain
Hematuria
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12
Q

Clinical Presentation of Pyelonephritis

A
Symptoms of cystitis may or may not be present
Chills
Flank pain with CVA tenderness
N/V
Appears ill
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13
Q

Diagnostic Tests for Cystitis

A

UA
Positive leukocyte esterase +/- nitrites
Consider urine culture with sensitivities

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14
Q

Diagnostic Tests for Pyelonephritis

A

UA

Urine culture & sensitivities

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15
Q

Treatment of Cystitis in Women

A

Nitrofurantoin
Bactrim
Fosfomycin
Phenozopyridine (Pyridium)

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16
Q

Differential for Men with Cystitis

A

Prostatitis
Urethritis secondary to STI
Urinary tract abnormality
Nephrolithiasis

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17
Q

Treatment of Cystitis in Men

A

Trimethoprim-sulfamethoxazole (Bactrim)

Fluoroquinolone

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18
Q

Outpatient Treatment for Pyelonephritis

A

Mild to moderate illness
Fluoroquinolone resistance low: Cipro or levoquin
Other: Bactrim or Augmentin

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19
Q

Inpatient Treatment for Pyelonephritis

A

Oral fluoroquinolone + aminoglycoside

Extended spectrum cephalosporin

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20
Q

Symptoms of Non-infectious Cystitis

A

Similar to cystitis with nocturne

Pressure in pelvis

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21
Q

Irritants of Non-infectious Cystitis

A
Bubble baths
Feminine hygiene sprays
Tampons
Spermicidal jellies
Chemoradiation
Foods: tomatoes, artificial sweeteners, caffeine & chocolate
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22
Q

Work-up of Non-infectoius Cystitis

A

UA
Urine culture
Sometimes cystoscopy

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23
Q

Treatment of Non-infectious Cystitis

A

Avoiding irritants
Voiding routine
Kegel’s

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24
Q

Manifestations of Chlamydia in Males

A

Urethritis: symptomatic or asymptomatic
Epididymitis
Prostatitis

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25
Diagnosing Chlamydia in Males
NAAT testing
26
Treatment of Chlamydia
Azithromycin | Rocephin
27
Presentation of Gonorrhea in Males
Symptomatic urethritis | Epididymitis: age
28
Diagnosing Gonorrhea in Males
NAAT testing
29
Treatment of Gonorrhea
Azithromycin | Rocephin
30
Presentation of Overactive Bladder Without Incontinence
Urgency Frequency Nocturia
31
Pathophysiology of Overactie Bladder Without Incontinence
Detruser muscle contracts irregularly at small volumes Usually idiopathic Can be secondary to DM, stroke, spinal disease
32
Treatment of Overactive Bladder
Anti-muscarinics
33
SE of Anti-muscarinics
No spit No shit No pee No see
34
MOA of Anti-muscarinics
Increase bladder capacity | Block basal release of acetyl choline during bladder filling
35
Anti-muscarinic Agents for Overactive Bladder
Oxybutynin (ditropan) Tolterodine (Detrol) Solifenacin (Vesicare)
36
New Agent for the Treatment of Overactive Bladder
Mirabegron (Myrbetriq) | Beta 3-adrenoceptor agonist
37
SE of Mirabegron (Myrbetriq)
HTN Incomplete bladder emptying Dry mouth
38
Medical Morbidity of Urinary Incontinence
Perineal candida infection Cellulitis & pressure ulcers UTIs & urosepsis Falls & fractures from slipping on urine Sleep interruption & deprivation Psychologically: poor self esteem, social withdrawal, depression & sexual dysfunction
39
Reasons for Sexual Dysfunction with Urinary Incontinence
Afraid of leaking urine during sex
40
Pathophysiology of Incontinence
Non-intact micturition physiology | Lack of functional ability to toilet oneself
41
Risk Factors for Incontinence
``` Obesity Functional impairment Parity (# of pregnancies) Family history Smoking Age DM Stroke Depression Estrogen depletion Genitourinary surgery Radiation ```
42
Transient Causes of Incontinence
``` D: delirium I: infection A: atrophic vaginitis P: pharmacologic P: psychological E: excessive urine production R: restricted mobility S: stool impaction ```
43
Pharmacologic Causes of Incontinence
Sedatives Diuretics Anti-cholinergics
44
Excessive Urine Production Causes of Incontinence
``` Diuretics ADH problems Psychogenic polydipsia DM Hypercalcemia ```
45
Incontinence Questions for Screening
In the past 3 months have you leaked urine? Which precipitants led to leakage? Which precipitant caused leakage most often? Do you ever wear pads, tissue or cloth in your underwear to catch urine?
46
Important History for Incontinence
Questions about incontinence Precipitants Bowel & sexual function Status of other medical conditions, parity, & meds Any prior continence therapy, particularly surgical treatments
47
Etiology of Urge Incontinence
Uninhibited bladder contractions Detrusor over activity May be due to bladder abnormalities or idiopathic
48
Presentation of Urge Incontinence
Sudden urge to void: nocturia, frequency Preceded or accompanied by leakage of urine More common in older women Also seen in men
49
Define Stress Incontinence
Leakage of urine with increased intra-abdominal pressure in the absence of a bladder contraction
50
Stress Incontinence Due to
Urethral hypermobility | Intrinsic sphincter deficiency
51
Mixed Incontinence
Most common type in women | Vary in predominance and/or bother of urge or stress leakage
52
Define Incomplete Emptying
Continuous leakage or dribbling of ruine
53
Causes of Incomplete Emptying
Detruser underactivity | Bladder outlet obstruction
54
Reasons for Detrusor Underactivity
Low estrogen Aging Peripheral neuropathy due to DM, chemo, B12 deficiency, meds, ETOH Damage to the spinal detrusor efferents (MS)
55
Possible Etiologies of Nocturia
CHF Late evening beveragesSleep apnea Sleep disturbances: chronic pain, depression Detrusor overactivity
56
Diagnostic Tool for Bladder Issues
Bladder diary
57
Bladder Diary
``` Record time & volume of continent & incontinent voiding Activity Caffeine intake House of sleep Episodes of nocturia ```
58
Physical Exam in a Patient with Urinary Incontinence
``` Heart Lungs Neurologic conditions Check for cystocele/rectocele, atrophy Have patient cough: look for leakage Examination of the prostate Cognitive & functional status ```
59
Post-Void Residual
How much urine is left in the bladder after the patient empties their bladder
60
Labs for Urinary Incontinence
``` Renal function Serum calcium & glucose UA PSA for men if indicated Urine cytology if there is hematuria or pelvic pain Increased post-void residual ```
61
Treatment of Urinary Incontinence
``` Weight loss Adequate but not excessive fluid intake Avoid caffeinated beverages & alcohol Minimize evening fluid intake for nocturia Smoking cessation Behavioral therapy Pessiaries Pharmacotherapy ```
62
Behavioral Therapy for Urinary Incontinence
Bladder training: frequent voluntary voiding, relaxation techniques for urge incontinence Kegel exercises Biofeedback
63
Pharmacotherapy for Urge & Mixed Incontinence
Tolterodine (Detrol LA) Solifenacin (Vesicare) Oxybutynin (Ditropan): IR, ER, Patch
64
SE of Anti-muscarinics
``` Dry mouth Blurred vision Constipation Drowsiness Decreased cognitive function ```
65
Contraindication of Anti-muscarinics
Narrow angle glaucoma
66
MOA of Oxybutynin (Ditropan)
Direct antispasmodic effect on detrusor muscle
67
MOA of Miragebron (Myratriq)
Causes bladder relaxation
68
SE of Miragebron (Myratriq)
``` HTN Tachycardia Urinary retention Inflammation of the nasal passages Dry mouth Constipation Abdominal pain Memory problems ```
69
Surgical Therapy for Incontinence
Used for stress incontinence | Abdominal or vaginal approaches
70
Vaginal Surgical Therapy Includes
Midurethral sling Bladder neck sling Submucosal injection of urethral bulking agents
71
Mesh Related Complications of Surgeries Performed Prior to New Guidelines
``` Mesh exposure (erosion) Dyspareunia Infection urinary problems Bleeding Organ perforation Deaths associated with bowel perforation or hemorrhage ```
72
When to Immediately Refer for Urinary Incontinence
``` Incontinence with abdominal and/or pelvic pain Hematuria in the absence of UTI Suspected fistula Complex neurological conditions Abnormal findings ```
73
When to Electively Refer for Urinary Incontinence
Persistent symptoms after adequate therapeutic trial Uncertainty in diagnosis Significantly elevated PVR that doesn't resolve after treatment of precipitants Prior pelvic surgery or pelvic irritation Desiring surgical therapy for stress incontinence
74
Presentation of Interstitial Cystitis
Persistent pain or "unpleasant" sensation with filling of the bladder, relieved with voiding Gradual onset with worsening symptoms Urinary frequency Urgency Nocturia
75
Diagnosis of Interstitial Cystitis
``` Through PE Tender suprapubic area Dyspareunia Irritable bowel Vulvodynia UA & culture ```
76
Define Interstitial Cystitis
Unpleasant sensation perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than 6 weeks duration in the absence of infection or other identifiable causes
77
1st Line Management of Interstitial Cystitis
Patient education noting reasonable expectations about pain relief & chronicity of condition Psychosocial support Self-care & behavior modification
78
2nd Line Management of Interstitial Cystitis
PT: patients with pelvic muscle pain Meds: amitriptyline, pentosan polysulfate sodium (PPS), hydroxyzine
79
MOA of Pentosan Polysulfate Sodium (PPS)
Reconstitues deficient protective glycosaminoglycan layer over the urothelium