Blistering Dermatoses Flashcards Preview

Pathoma - Skin Pathology Ch19 > Blistering Dermatoses > Flashcards

Flashcards in Blistering Dermatoses Deck (15):
1

Pathology of Pemphigus vulgaris, type of hypersenistivity reaction?

Autoimmune destruction of desmosomes between keratinocytes, IgG Ab against desmoglein (type II hypersensitivity

2

Pemphigus vulgaris histological presentation

Acantholysis of stratum spinosum keratinocytes from stratum basalis resulting in basal layer cells attached to basement membrane with "tombstone appearance".

3

What is Nikolsy sign?

Easy rupture of blisters in pemphigus vulgaris leading to shallow erosions with dried crusts

4

What are the findings for Pemphigus vulgaris on immunofluorescence?

Highlights IgG surrounding keratinocytes in "fishnet" pattern

5

What is Bullous Pemphigoid?

Autoimmune destruction of hemidesmosomes b/w basal cells and underlying basement membrane due to IgG Abs (hemidesmosome components BP180)

6

Bullous Pemphigoid presentation

Generally elderly with blisters on skin, oral mucosa is spared

7

What is the cause of the clinical presentation in Bullous Pemphigoid?

The blisters do not easily rupture because the entire dermis is involved

8

Histological findings of Bullous Pemphigoid?

Immunofluorescence highlights IgG along basement membrane (linear pattern)

9

What is Dermatitis Herpetiformis?

Autoimmune deposition of IgA at tips of dermal papillae

10

Clinical presentation of Dermatitis Herpetiformis?

Pruritic vesicles and bullae that are grouped

11

What disease is Dermatitis Herpetiformis associated with?

Celical disease - resolves with gluten-free diet

12

What is Erythema Multiforme?

Hypersensitivity rxn characterized by targetoid rash (central epidermal necrosis surrounded by erythema) and bullae

13

What conditions are associated with Erythema Multiforme?

HSV, Mycoplasma infection, Drugs (penicillin/sulfonamides), Autoimmune disease (SLE), malignancy

14

What is Stevens-Johnson Syndrome?

Erythema Multiforme with oral mucosa/lip involvement and fever

15

What is Toxic Epidermal Necrolysis?

Severe form of SJS characterized by diffuse sloughing of skin, resembling large burn; Frequently due to adverse drug reaction