Lippencott's Ch 24 - Skin Flashcards Preview

Pathoma - Skin Pathology Ch19 > Lippencott's Ch 24 - Skin > Flashcards

Flashcards in Lippencott's Ch 24 - Skin Deck (39):
1

What are scaly, frequently pigmented, elevated papules with scales that are easily rubbed off called?

Seborrheic keratoses

2

What are broad anastomosing cords of mature stratified squamous epithelium associated with small cysts of keratin?

Seborrheic keratoses

3

What is CDKN2A better known as?

p16

4

A mutation in what gene has been found in patients with dysplastic nevus/melanoma?

Cyclin Dependent Kinase 2A (CDKN2A)

5

What kind of gene is CDKN2A?

Tumor Suppressor Gene

6

What can actinic keratoses lead to?

Squamous Cell Carcinoma

7

What is the following describing: Cytologic atypia and dyskeratosis limited to the basal layers of the stratum spongiosum as well as kyperkeratosis and parakeratosis

Actinic Keratosis

8

What virus plays a role in Kaposi Sarcoma?

HHV-8

9

What is the following describing: Painful, purple nodules on the dorsal surface of left hand (chronic) with similar lesions found in the liver and lymphnodes

Kaposi Sarcoma

10

What is the genetic component of Ichthyosis vulgaris?

Autosomal dominant disorder

11

Describe the processes that occur in the epidermis of a person with Ichthyosis vulgaris

Mild hyperkeratosis and reduced/absent keratohyaline granules in the epidermis

12

What causes the scaling in Ichthyosis vulgaris?

Increased cohesiveness of the stratum corneum

13

What condition has a thin stratum granulosum?

Ichthyosis vulgaris

14

What is another name for Lentigo maligna melanoma?

Hutchinson melanotic freckle

15

In psoriasis, what cells accumulate in the epidermis? Dermis?

Neutrophils; B and T lymphocytes

16

When are blisters noted in Epidermolysis Bullosa?

Frequently after birth

17

Patient presents with separation of the basal layer of the epidermis from the dermis without immunofluorescence. What is the likely Dx?

Epidermolysis Bullosa

18

What is the protein targeted in pemphigus vulgaris by autoAbs? Therefore, which layers separate?

Desmoglein-3, Stratum spinosum from the stratum basalis

19

What is the most common malignant tumor in persons with pale skin?

Basal Cell Carcinoma

20

A patient with papillomatous lesions presents at the clinic. What is the likely Dx?

Verruca vulgaris

21

What is Erythema Nodosum frequently associated with?

Drugs and microorganisms

22

What are the two basement membrane proteins associated with Bullous Pemphigoid?

BPAG1 and BPAG2

23

What skin condition is related to Celiac's Disease?

Dermatitis Herpetiformis

24

What bacteria is associated with acne?

Propionibacterium acnes

25

What processes occur in the epidermis of a person with Lichen Planus?

hyperkeratosis with little/no parakeratosis, stratum granulosum is thickened

26

What is a big histologic clue to a Lichen Planus Dx?

Saw-tooth dermal papillae

27

Where does Lichen planus generally occur?

Flexor surfaces of wrists

28

What are Wickham's Striae?

Patches/streaks on oral mucosa present in lichen planus

29

What is Mycosis Fungoides?

Variant of cutaneous T-cell lymphoma

30

What is Sezary Syndrome?

Systemic dissemination of mycosis fungoides

31

What is another name for cutaneous necrotizing vasculitis?

Leukocytoclastic vasculitis

32

Describe pathogenesis of cutaneous necrotizing vasculitis

Immune complexes and C5a activate neutrophils which release lysosomal enzymes and obliterate blood vessels

33

What kind of condition is cutaenous necrotizing vasculitis?

Hypersensitivity rxn

34

What is a key clinical feature of cutaneous necrotizing vasculitis?

Palpable purpura

35

What are Langerhans cells?

Antigen presenting cells

36

In what type of skin reaction is Langerhan cell migration to the lymphatics critical?

Allergic Contact Dermatitis

37

What cells interact in the sensitization phase of allergic contact dermatitis?

Langerhans cells and CD4+ T helper cells

38

What condition is associated with fibrosis and tightening of the skin?

Scleroderma

39

What does the mnemonic, "CREST" stand for?

calcinosis/anti-centromere, raynaud's, esophageal dysmotility, sclerodactyly, telangiectasias