Flashcards in Lippencott's Ch 24 - Skin Deck (39):
What are scaly, frequently pigmented, elevated papules with scales that are easily rubbed off called?
What are broad anastomosing cords of mature stratified squamous epithelium associated with small cysts of keratin?
What is CDKN2A better known as?
A mutation in what gene has been found in patients with dysplastic nevus/melanoma?
Cyclin Dependent Kinase 2A (CDKN2A)
What kind of gene is CDKN2A?
Tumor Suppressor Gene
What can actinic keratoses lead to?
Squamous Cell Carcinoma
What is the following describing: Cytologic atypia and dyskeratosis limited to the basal layers of the stratum spongiosum as well as kyperkeratosis and parakeratosis
What virus plays a role in Kaposi Sarcoma?
What is the following describing: Painful, purple nodules on the dorsal surface of left hand (chronic) with similar lesions found in the liver and lymphnodes
What is the genetic component of Ichthyosis vulgaris?
Autosomal dominant disorder
Describe the processes that occur in the epidermis of a person with Ichthyosis vulgaris
Mild hyperkeratosis and reduced/absent keratohyaline granules in the epidermis
What causes the scaling in Ichthyosis vulgaris?
Increased cohesiveness of the stratum corneum
What condition has a thin stratum granulosum?
What is another name for Lentigo maligna melanoma?
Hutchinson melanotic freckle
In psoriasis, what cells accumulate in the epidermis? Dermis?
Neutrophils; B and T lymphocytes
When are blisters noted in Epidermolysis Bullosa?
Frequently after birth
Patient presents with separation of the basal layer of the epidermis from the dermis without immunofluorescence. What is the likely Dx?
What is the protein targeted in pemphigus vulgaris by autoAbs? Therefore, which layers separate?
Desmoglein-3, Stratum spinosum from the stratum basalis
What is the most common malignant tumor in persons with pale skin?
Basal Cell Carcinoma
A patient with papillomatous lesions presents at the clinic. What is the likely Dx?
What is Erythema Nodosum frequently associated with?
Drugs and microorganisms
What are the two basement membrane proteins associated with Bullous Pemphigoid?
BPAG1 and BPAG2
What skin condition is related to Celiac's Disease?
What bacteria is associated with acne?
What processes occur in the epidermis of a person with Lichen Planus?
hyperkeratosis with little/no parakeratosis, stratum granulosum is thickened
What is a big histologic clue to a Lichen Planus Dx?
Saw-tooth dermal papillae
Where does Lichen planus generally occur?
Flexor surfaces of wrists
What are Wickham's Striae?
Patches/streaks on oral mucosa present in lichen planus
What is Mycosis Fungoides?
Variant of cutaneous T-cell lymphoma
What is Sezary Syndrome?
Systemic dissemination of mycosis fungoides
What is another name for cutaneous necrotizing vasculitis?
Describe pathogenesis of cutaneous necrotizing vasculitis
Immune complexes and C5a activate neutrophils which release lysosomal enzymes and obliterate blood vessels
What kind of condition is cutaenous necrotizing vasculitis?
What is a key clinical feature of cutaneous necrotizing vasculitis?
What are Langerhans cells?
Antigen presenting cells
In what type of skin reaction is Langerhan cell migration to the lymphatics critical?
Allergic Contact Dermatitis
What cells interact in the sensitization phase of allergic contact dermatitis?
Langerhans cells and CD4+ T helper cells
What condition is associated with fibrosis and tightening of the skin?