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Flashcards in Block 1 Deck (23)
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1

Which of the following is energy independent?
A. Necrosis
B. Apoptosis

A. Necrosis

2

Which of the following is dependent on intracellular iron for cell death?
A. Pyroptosis
B. Paraptosis
C. Ferroptosis
D. Parthanatos

C. Ferroptosis

3

The displacement of the cytoplasm by large fluid-filled vacuoles derived from macropinosomes is a hallmark feature of?

Methuosis

4

The apoptosome is composed of what?

cytochrome c, dATP, Apaf-1, caspase 9

5

Which BCL-2 sensor is essential for deletion of autoreactive B&T cells during development?

Bim

6

Which of the following is an anti-apoptotic Bcl-2 regulators?
A. PUMA
B. Bim
C. Bcl-x
D. Bak

C. Bcl-x

7

Cytochrome c is normally located where?
A. Endoplasmic reticulum
B. Within inner membrane of mitochondria
C. Between outer and inner membranes of mitochondria
D. Lysozomes

C. Between outer and inner membranes of mitochondria

8

In the intrinsic pathway of apoptosis, which caspase is the initiator caspase?
A. Caspase 3
B. Caspase 7
C. Caspase 8
D. Caspase 9

D. Caspase 9

9

Which caspase is the initiator caspase for extrinsic pathway of apoptosis?
A. Caspase 3
B. Caspase 7
C. Caspase 8
D. Caspase 9

C. Caspase 8

10

Which of the following is an example of an IAP?
A. Survivin
B. Cytochrome c
C. Caspase 3
D. SMAC

A. Survivin

11

Which of the following proteins is expressed during apoptosis to encourage phagocytosis of the cell?
A. PUMA
B. Apaf-1
C. Diablo
D. Phosphatidylserine

D. Phosphatidylserine

12

Which of the following is a DNA repair enzyme that can be cleaved and used as a diagnostic tool for apoptosis?
A. Apaf-1
B. PARP
C. Survivin
D. Cytochrome c

B. PARP

13

In the extrinsic pathway of apoptosis, FasL binds to what extracellular receptor?
A. FLIP
B. TRAIL
C. Pro-caspase 8
D. CD95

D. CD95

14

Which of the following inhibits the activation of pro-caspase 8 to caspase 8?
A. C-FLIP
B. FADD
C. Bid
D. DIABLO

A. C-FLIP

15

Which of the following is activated in the extrinsic pathway of apoptosis and activates the intrinsic pathway?
A. IAPs
B. Bid
C. Caspase 8
D. C-FLIP

B. Bid

16

Which of the following is a shock caspase?
A. Caspase 6
B. Caspase 7
C. Caspase 9
D. Caspase 11

D. Caspase 11

17

Necroptosis is mediated by which of the following?
A. Bcl-2 proteins
B. MPTP
C. Cytochrome-c
D. Fas

B. MPTP

18

Ligation of TNFR1 recruits RIP-1 and RIP-3 into a complex with which caspase?
A. Caspase 6
B. Caspase 8
C. Caspase 11
D. Caspase 13

B. Caspase 8

19

Which protein serves as a marker for a lysozome to bind with an autophagosome?
A. LC3
B. Hsp 70
C. Ubiquitin
D. Hsp 60

A. LC3

20

Which protein serves as a chaperone to bring proteins into the mitochondria?
A. Hsp 70
B. Hsp 60
C. Ubiquitin
D. C-FLIP

B. Hsp 60

21

What complex serves as the major upstream inhibitor of autophagy?
A. Beclin-1 complex
B. MTORC-1 complex
C. ULK complex
D. PI3KC1 complex

B. MTORC-1 complex

22

Which complex activates mTORC1?
A. ULK1/ULK2
B. PI3KC1
C. Atg 13
D. Beclin-1

B. PI3KC1

23

Name the components of the MTORC1

MTOR, raptor, Deptor, PRAS40, GbetaL