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Immuno Block 1 > Block 1 Terms > Flashcards

Block 1 Terms Flashcards

1
Q

This is on naive T cells; it recognizes chemokines to bring them to the PALS in spleen and paracortex in lymph node

A

CCR7

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2
Q

Naïve T cells express & binds to carbohydrate ligands expressed only on the endothelial cells of HEVs.

A

L-Selectin

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3
Q

This is present on Activated T cells to draw T cells out of the nodes into the blood/circulation

A

Sphingosine 1-phosphate receptors

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4
Q

TNFα

A

Cytokine that attracts neutrophils. Produced by macrophages and dendritic cells

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5
Q

Cytokine that attracts neutrophils. Produced by macrophages and dendritic cells.
It plays a significant role in linking innate immunity and adaptive immunity
-pro-inflammatory cytokine

A

TNFα

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6
Q

Cytokine that attracts neutrophils. Produced by macrophages and dendritic cells.

  • It plays a significant role in linking innate immunity and adaptive immunity
  • stimulates inflammation
A

IL-1

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7
Q

Cytokine that plays a significant role in linking innate immunity and adaptive immunity

A

IL-6

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8
Q

This is an example of a Pattern Recognition Receptor in Innate Immunity which activates NF-κB and IRF-3
-they activate microbial function of macrophages

A

Toll-like receptors

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9
Q

This is an example of a Pattern Recognition Receptor in Innate Immunity
-microbial proteins have these, which are recognized by the receptor on the cell surface

A

N-formyl methionyl receptor

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10
Q

An example of a Pattern Recognition Receptor in Innate Immunity

  • they don’t recognize our self-cell glycoprotein but recognize bacteria
  • when these bind their ligands, they trigger phagocytosis of microbes
A

Mannose Receptor

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11
Q

this is activated by TLRs,
- it is Responsible for genes that activate the cells in the blood vessel in the endothelium that are in the area of the infection; promotes expression of various cytokines and endothelial adhesion molecules

A

NF-κB

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12
Q

this is activated by TLRs, stimulates production of antiviral type I interferons, cytokines that block viral replication

A

IRF-3

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13
Q

this is a part of the innate immune system - they go into membrane and form “carpet wormholes” = cell lysis

A

Defensins

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14
Q

these are important in leukocyte transmigration through blood vessels/inter-cellular junctions of vascular endothelial cells

A

PECAM-1

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15
Q

Present on Endothelial cells, recognizes carbs on leukocytes
plays an important rold in recruitment of cells to inflammatory sites.

A

E- Selectin

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16
Q

Cytokine in innate and adaptive immunity

  • released by NK cells,
  • activates macrophages to kill phagocytosed microbes
A

IFN-γ

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17
Q

this recognizes microbes coated with C3b (opsonin) to = phagocytosis

A

CR1

18
Q

Converts O2 to superoxide anion and free radicals

A

Phagocyte (NADPH) oxidase

19
Q

converts arginine to nitric oxide(NO)

A

iNOS

20
Q
  • Cytokine released by macrophages, recognized by NK cells which secrete IFN-γ for phagocytosis
  • stimulaes differentiation into TH1 T-cells
A

IL- 12

21
Q

Specific for IgG bound Ab, used in ADCC (antibody- dependent cellular cytotoxicity), recruits NK cells for apoptosis

A

FcgRIIIA receptor

22
Q

Activating receptors on NK cells found in cytoplasmic tails

A

immunoreceptor tyrosine-based activation motifs (ITAMs)

23
Q
  • Inhibitory Receptors on NK cells, -Specific for Class I MHC receptors, block signaling from activating receptors
  • found in cytoplasmic domains
A

immunoreceptor tyrosine-based inhibitory motifs

(ITIMs)

24
Q

Secreted by macrophages to work on macrophages and inhibit IL-12

A

IL-10

25
Q

Receptor on T cells that recognize costimulators for signal #2 in activation

A

CD28

26
Q

Example of a costimulator that is recognized by the CD28 receptors on T Cells. Made by macrophages

A

B7

27
Q

Product of complement which is an opsonin and recognized by macrophages

A

C3b

28
Q

Interacts with CR2 Type 2 complement receptor on B cells to activate(2nd signal) along with antigen

A

C3d

29
Q

Type 2 complement receptor on B cells used a 2nd signal to activate B cells

A

CR2

30
Q

Invariant and is the binding site for CD8+ T cells

A

α3 domain on MHC I

31
Q

Variant and form the peptide binding cleft

A

α1 and α2 domains on MHC Class I

32
Q

Invariant and is the binding site for CD4+ T cells

A

β2 domain of class II

33
Q

Variant and form the peptide binding cleft

A

α1 and β1 domains on MHC Class II

34
Q

Expressed on all nucleated cell, present antigen to CD8+ T cells
Acquire peptides from cytosolic proteins

A

Class I MHC molecules

35
Q

Expressed on dendritic cells, macrophages and B lymphocytes and present antigen to CD4+ T cells
Acquire peptides from intracellular vesicles (endosomes, phagosomes)

A

Class II MHC molecules

36
Q 
Protein chain present on MHC class II to block the peptide binding cleft to stop binding endogenous peptides made for the Class I pathway. 
Also facilitates the transport of MHC Class II to the endosome from the ER.
A

invariant chain protein (Ii)

37
Q

Proteins that grab endogenous peptides and brings them to the ER to interact with MHC class I

A

TAP proteins

38
Q

atalyzes the removal of the CLIP peptide and facilitates the binding of the peptide antigens.

A

HLA- DM

39
Q

What remains of the invariant chain after most has been degraded once it gets to the endosome.
Remains in the binding cleft.

A

CLIP (Class II Invariant chain Peptide)

40
Q

The peptides that bind the MHC molecules and stimulate an immune response. Only certain peptides on the antigens can bind to the MHC molecule so these “epitopes” that bind start their immune response

A

Immunodominant Epitopes

Immuno Block 1 (5 decks)

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