Block 12 Flashcards Preview

Pharm > Block 12 > Flashcards

Flashcards in Block 12 Deck (152)
Loading flashcards...
1

Drug to prevent malaria caused by vivax

Chloroquine

2

Drug(s) to treat malaria caused by vivax

Chloroquine +/-primaquine

- use primaquine if in liver stages

3

Drug to prevent malaria caused by falciparum

Mefloquine

4

Drug(s) to treat malaria caused by falciparum

Quinine + doxycycline

5

3 protozoal infections treated with metronidazole

- giardiasis
- e. Histolytica
- trichomoniasis

6

Drugs to treat protozoal infection: toxoplasmosis

Pyrimethamine + sulfadiazine

7

drugs to treat nematodes

- albendazole and mebendazole
- pyrantel
- ivermectin

8

Nematode MOA: inhibit microtuble synthesis and decrease glucose uptake

Albendazole and mebendazole

9

DOC for pinworms

Albendazole and mebendazole

10

Nematode MOA: Nm agonist, act like SCh, and cause paralysis

Pyrantel

11

Nematode MOA: GABA agonist, hyperpolarization of nerves and muscles

Ivermectin

12

DOC for onchocerciasis

Ivermectin

13

What is onchocerciasis

River blindness

14

Drug for trematodes and cestodes

Praziquantel

15

MOA: increase Ca permeability, causing contractions, leading to paralysis of worm

Praziquantel

16

Fungal MOA: inhibit squalene epoxidase, which inhibits ergosterol synthesis

Terbinafine

17

Does terbinafine treat systemic or superficial fungal infections

Superficial

18

Only fungal drug that affects cell wall

Fungin’s

19

Fungal MOA: binds to ergosterol and forms pores

Ampho B

20

Synergism for fungal infections

Ampho B + flucytosine

21

Adverse effects of ampho B

- flushing
- bone marrow suppression
- nephrotoxic

22

Fungal MOA: makes 5dUMP which inhibits thymine synthesis (which inhibits DNA synthesis)

Flucytosine

23

Fungal MOA: blocks C1,4 a-demethylase which causes lanosterol to accumulate

Azoles

24

DOC for candidas and cryptococcus meningitis

Fluconazole

25

If pt comes in with serious fungal infection, what is immediately started

Ampho B + flucytosine

26

DOC for aspergillius

Voriconazole

27

Fungal MOA: inhibit B- glucan synthesis

Fungin’s

28

5 drugs for TB

- isoniazid
- rifampin
- pyrazinamide
- ethambutol
- streptomycin

29

Initiation phase Tx of TB

- isoniazid
- rifampin
- pyrazinamide
- ethmbutol

For 2 months

30

Continuation phase of TB Tx

- isoniazid
- rifampin

For 4 months