Block 2 Flashcards
(195 cards)
fundamental purpose of the cardiorespiratory system
to deliver O2 and nutrients to cells and to remove CO2 and other metabolic products from them.
switch from aerobic to anaerobic metabolism
Pasteur effect
The adaptations to hypoxia are mediated, in part, by the upregulation of genes encoding a variety of proteins, including
- glycolytic enzymes, such as phosphoglycerate kinase and phosphofructokinase
- glucose transporters Glut-1 and Glut-2
- growth factors, such as vascular endothelial growth factor (VEGF) and erythropoietin, which enhance erythrocyte production.
The hypoxia-induced increase in expression of these key proteins is governed by this hypoxiasensitive transcription factor?
hypoxia-inducible factor-1 (HIF-1).
During hypoxia, systemic arterioles
During hypoxia, systemic arterioles dilate, at least in part, by opening of K-ATP channels in vascular smooth-muscle cells due to the hypoxia-induced reduction in ATP concentration.
What happens in pulmonary vascular smooth-muscle cells during hypoxia?
By contrast, in pulmonary vascular smooth-muscle cells, inhibition of K+ channels causes depolarization which, in turn, activates voltage-gated Ca2+ channels raising the cytosolic [Ca2+] and causing smooth-muscle cell contraction.
Hypoxia-induced pulmonary arterial constriction shunts blood away from poorly ventilated portions toward better ventilated portions of the lung; however, it also increases pulmonary vascular resistance and right ventricular afterload.
Acute hypoxia causes
impaired judgment, motor incoordination, and a clinical picture resembling acute alcohol intoxication.
High-altitude illness is characterized
by
headache secondary to cerebral vasodilation, gastrointestinal symptoms,
dizziness, insomnia, fatigue, or somnolence.
Pulmonary arterial and sometimes venous constriction causes
capillary leakage and high-altitude pulmonary edema (HAPE), which intensifies hypoxia, further promoting vasoconstriction. Rarely, high-altitude cerebral edema (HACE) develops, which is manifest by severe headache
and papilledema and can cause coma. As hypoxia becomes more severe, the regulatory centers of the brainstem are affected, and death usually results from respiratory failure.
When hypoxia occurs from respiratory
failure, Pao2 ?
declines
when respiratory failure is persistent, the
hemoglobin-oxygen (Hb-O2) dissociation curve?
is displaced to the right, with greater quantities of O2 released at any level of tissue Po2.
TRUE OR FALSE:
Arterial hypoxemia, that is, a reduction of O2 saturation of arterial blood (Sao2), and consequent cyanosis are likely to be more marked when such depression of Pao2 results from pulmonary disease than when the depression occurs as the result of a decline in the fraction of oxygen in inspired air (Fio2).
TRUE
What happens when the depression occurs as the result of a decline in the fraction of oxygen in inspired air (Fio2)?
In this latter situation, Paco2 falls secondary to anoxia induced hyperventilation and the Hb-O2 dissociation curve is displaced to the left, limiting the decline in Sao2 at any level of Pao2.
The most common cause of respiratory hypoxia is ?
ventilation-perfusion mismatch resulting from perfusion of poorly ventilated alveoli.
Respiratory hypoxemia may also be caused by hypoventilation, in which
case it is associated with ?
an elevation of Paco2
A third cause of respiratory hypoxia is shunting of blood across the lung from the pulmonary arterial to the venous bed (intrapulmonary right-to-left shunting) by perfusion of nonventilated portions of the lung, as in?
pulmonary atelectasis or through pulmonary arteriovenous connections.
The low Pao2 in intrapulmonary right-to-left shunting is corrected by?
The low Pao2 in this situation is only partially corrected by an Fio2 of 100%.
ventilation-perfusion mismatch & hypoventilation can be corrected by?
These two forms of respiratory hypoxia are usually correctable by inspiring 100%
O2 for several minutes.
From a physiologic viewpoint, this cause of hypoxia resembles intrapulmonary right-to-left shunting but is caused by congenital cardiac malformations, such as?
- tetralogy of Fallot
- transposition of the great arteries
- Eisenmenger’s syndrome
Pao2 in anemic hypoxia
normal
the presence of COHb shifts the Hb-O2 dissociation curve to the ?
left
This pathophysiology
leads to an increased arterial-mixed venous O2 difference
(a-v-O2 difference), or gradient.
circulatory hypoxia
Generalized circulatory hypoxia occurs
in ?
heart failure and in most forms of shock
clinical
picture of patients with hypoxia due to an elevated metabolic rate, as
in fever or thyrotoxicosis,
the skin is warm and flushed owing to increased cutaneous
blood flow that dissipates the excessive heat produced, and cyanosis is
usually absent.