Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Flashcards Preview

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Flashcards in Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Deck (75)
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1

What are the 4 major brain DA pathways?

1) nigrostriatal
2) mesolimbic
3) mesocortical
4) tuberinfundibular

2

Describe the anatomy of the mesolimbic pathway.

VTA projects to:
-- NAc
-- HP
-- Amy

3

Describe the anatomy of the mesocortical pathway.

VTA projects to PFc

4

Describe the anatomy of the tuberinfundibular pathway.

arcuate nucleus of HT projects to median eminence; median eminence projects to AP to decrease PRL release

5

What is the function of the mesocortical pathway?

executive function
-- decision-making
-- impulsivity

6

What is the function of the mesolimbic pathway?

1) positive reinforcement
2) learning/memory
3) emotional control

7

How do drugs of abuse cause addiction?

increase DA in mesolimbic pathway
-- positive reinforcement, learning/memory, emotional control

8

Describe the anatomy of the nigrostriatal pathway.

Substantia nigra projects to striatum

9

What pathway is affected in PD?

nigrostriatal DA pathway

10

For what conditions are DAr agonists used?

1) PD
2) ADHD
3) hyper-PRL
4) RLS

11

For what conditions are DAr antagonists used?

1) anti-emetics
2) anti-psychotics
3) movement disorders (Huntingtons, Tourettes, dystonias)

12

What are the main receptor classes of DAr's?

1) Gs (D1 and D5-like)
2) Gi (D2-, 3, and 4-like)

13

What is the function of D1/D5 Gs receptors?

-- in CNS
-- typically post-synaptic
-- increase cAMP

14

What is the function of D2/3/4-like Gi receptors?

-- in CNS
-- pre and postsynatpic (like a2 and M2)
-- decrease cAMP

15

Which DAr is cloned?

D5-like

16

What are the peripheral roles of 5-HT?

1) platelet aggregation (storage granules of platelets)
2) peristalsis, n/v (enterochromaffin)
3) blood vessels and cardiac valves

17

What are the central roles of 5-HT?

1) mood
2) appetite
3) sleep
4) n/v
5) nociception

18

In what conditions is 5-HT dysregulation implicated?

1) migraine
2) anxiety
3) schizophrenia
4) depression
5) n/v
6) aggression/hostility
7) OCD/phobias

19

Where is 5-HT synthesized?

from Trp in Raphe Nucleus

20

How is 5-HT broken down?

1) MAOb
2) synthesized into melatonin

21

Where is melatonin synthesized?

pineal gland

22

Where is serotonin stored?

serotonergic cell groups

23

Where are melatonin receptors located?

1) SCN
2) anterior pituitary
3) periphery

24

What are the 5-HT receptors?

1) 5HT1 (A,B,D) Gi
2) 5HT2 (A,B,D) Gq
3) 5HT3 LGIC
4) 5HT4 Gs

25

Where does LSD act?

5HT2 antagonist

26

Where do the triptans act?

5HT1 antagonist
5HT4 agonist

27

Which serotonin receptor is inhibitory?

5HT1 Gi

28

Which serotonin receptor is an LGIC?

5HT3

29

What are the signs/sxs of serotonin syndrome?

1) diarrhea
2) euphoria
3) drowsiness/dizziness
4) rapid eye movement and muscle contraction
5) hyperthermia
6) shivering, seizures
7) arrhythmia
8) loss of consciousness, death

30

What drugs can cause serotonin syndrome?

1) SSRIs
2) MAOIs
3) TCAs
4) triptans