Block 3 Anti-Inflammatory Flashcards Preview

Pharmacology > Block 3 Anti-Inflammatory > Flashcards

Flashcards in Block 3 Anti-Inflammatory Deck (17):
1

Aspirin

MOA: irreversible COX-I
SE: salicylism, ulcers, impaired gestation, Reye's syndrome, analgesic nephropathy
CI: lithium tox, warfarin tox,
OD Rx: NaHCO3

2

Ibuprofen, Naproxen, Diclofenac, Ketorolac, Sulindac, Indomethacin, Piroxicam

MOA: reversible COX-I
Ketorolac: post-op pain
Indomethacin: PDA closure
Diclofenac: Hepatic Toc

3

Celecoxib & Rofecoxib

MOA: reverisble COX2 inhib
SE: MI risk, renal dysfxn
Uses: anti-inflammatory

4

Acetaminophen

Only inhibits COX in cns
causes centrilobular heptox
OD Rx: N-Acetyl Cysteine

5

Hydroxychloroquine

MOA: stabilizes lysosomes & inhibits chemotaxis
SE: hemolysis, cinchonism, retinopathy

6

Methotrexate

MOA: cytotoxic to lymphocyte

7

Sulfasalazine

Met into Sulfapyradine & 5-ASA
Sulfapyridine inhibits B-cell fxns
5-ASA inhibits cox

8

Gold Salts

MOA: suppress phagocytosis & toxic to lymphocytes

9

Glucocorticoids

MOA: decreases leukotrienes, interleukins, & PAF
anti-inflammatory & immunosuppression

10

Penicillamine

MOA: suppresses T-cells & inhibits rheumatoid factor
used in chelates & Wilson's disease

11

Etanercept

MOA: decreases the effects of TNF-alpha by binding it
*prevents it from illiciting a response

12

Leflunomide

MOA: dihydro-orotic acid dehydrogenase
arrests lymphocytes in G1 phase

13

Infliximab

MOA: monoclonal antibody against TNF-alpha
*used for Crohn's
SE: infections

14

Anakinra

MOA: IL-1 receptor antagonist

15

NSAIDs & Colchicine (acute gout rx)

Colchicine: binds to tubulin during M-phase to inhibit micro-tubular polymerization
SE: heartburn

16

Allopurinol (chronic gout)

releases uric acid
MOA: inhibits xanthene oxidase

17

Probenecid & Sulfinpyrazone (chronic gout)

increase excretion of uric acid
MOA: dec tubular reabsorp of uric acids in pct & dec tub sec of WA