Blocks/ Epidurals/ Pain Management Flashcards
(91 cards)
Blocks/ Epidurals/ Pain Management
What are opioids/ narcotics?
Binds to Mu, Delta, Kappa receptor sites to produce morphine like or opioid agonist effect by acting on pain modulating system. Can be natural or synthetic.
Caution: watch out for respiratory depression.
Blocks/ Epidurals/ Pain Management
What is morphine?
Prototype for strength of other narcotics
Can cause histamine release
Can cause spasm of biliary smooth muscle
Useful in treatment of angina in ACS
Peak effect in 20 minutes
Blocks/ Epidurals/ Pain Management
Morphine facts
Route IV
Dose 2-15mg
Onset < 1 minute
Peak 20 minutes
Duration 2-7 hours
Blocks/ Epidurals/ Pain Management
What is hydromorphone?
6x more potent than morphine
Recommended in renal patients d/t lack of active metabolites after broken down in the liver
Can be administered spinal / epidural due to high lipid solubility
Blocks/ Epidurals/ Pain Management
Hydromorphone facts
Dose 0.5 - 2mg IV
Onset < 60 sec
Peak 5 - 20 min
Duration 2 - 4 hrs
Blocks/ Epidurals/ Pain Management
What is fentanyl?
100x more potent than morphine
Can cause fixed chest syndrome
Blocks/ Epidurals/ Pain Management
Fentanyl facts
Dose 0.05 - 2mcg/kg IV
Onset < 30 sec
Peak 3 - 7 min
Duration 30 - 60 min
Monitor patient for respiratory depression for at least 1 hour after admission to PACU
Note that fentanly is administered as weight based.
Blocks/ Epidurals/ Pain Management
What is fixed chest syndrome?
Can be caused by rapid IV injection of Fentanyl
Leads to bronchial constriction and resistance to ventilation, rigidity of diaphragmatic and intercostal muscles.
Reversal - administer subclinical dose of succinylcholine (w/c will relieve rigidity of chest wall?)
Additional action - Ventilate
Succinylcholine is a non depolarizing muscle relaxant.
Blocks/ Epidurals/ Pain Management
What is Meperidine?
1/10x as potent as morphine
Primary for post operative shivering
Not commonly used for pain
Contraindications
a. Use of MAOIs - d/t resp depression w/ concurrent use of meperidine
b. potentiates seizure because of toxic metabolite (normeperidine) that lowers seizure threshold and induce CNS excitability
Trivia - meperidine is chemically smilar to atropine
Blocks/ Epidurals/ Pain Management
What are commonly prescribed MAOIs?
Selegiline
Isocarboxazid
Phenelzine
Tranylcypromine
Blocks/ Epidurals/ Pain Management
Meperidine facts
Dose 12.5 - 25 mg
Onset 1 - 3 min
Peak 5 - 20 min
Duration 2 - 4 hrs
Blocks/ Epidurals/ Pain Management
What is opioid overdose treatment?
Naloxone
0.2 - 0.4mg reverses respiratory depression
Titrate 0.04mg to avoid acute reversal of analgesia
Monitor patient for possible return of respiratory depression.
Blocks/ Epidurals/ Pain Management
What are advantages of local anesthesia?
Postop analgesia on site
Safe for patients with systemic disease
Fewer side effects (PONV, sedation, respiratory depression)
Blocks/ Epidurals/ Pain Management
What is the MOA of local anesthesia?
Impairs conduction of nerve impulses
Alters cell permeability to Na2+
Attaches to site near Na2+ channel
Thus Na2+ channel is kept in closed position which slows depolarization and blocks conduction
Blocks/ Epidurals/ Pain Management
What are the disadvantages of local anesthesia?
Toxicity
Allergic reaction
IV injection
Inadvertent infiltration
Blocks/ Epidurals/ Pain Management
What are 2 different types of local anesthesia?
Esters and Amides
Blocks/ Epidurals/ Pain Management
What medications are classified as Esters - local anesthetics?
Esters (one “i”), ends with “caine”
1. Cocaine
2. Procaine
3. Chloroprocaine
4. Tetracaine
Blocks/ Epidurals/ Pain Management
What medications are classified as Amides - local anesthetics?
Amides (two “ii”), ends with “caine”
1. Prilocaine
2. Lidocaine
3. Mepivacaine
4. Bupivacaine
5. Etidocaine
6. Ropivacaine
Blocks/ Epidurals/ Pain Management
What to watch out for in administering Prilocaine (an Amide - local anesthetic)?
Can cause methemoglobinemia - abnormal amount of methemoglobin in the blood leading to hypoxia
d/t prilocaine toxic build up
s/s tachypnea, brown-grey cyanosis, metabolic acidosis, chocolate colored blood
Treat with methylene blue
Blocks/ Epidurals/ Pain Management
What to watch out for in administering Bupivacaine (an Amide - local anesthetic)?
Do not use for bier block
Can cause cardiac toxicity if excessive dose or accidental injection
Blocks sensory more than motor function
Blocks/ Epidurals/ Pain Management
What to watch out for in administering Mepivacaine (an Amide - local anesthetic)?
Do not use for spinal anesthesia
Great alternative to lidocaine with epinephrine without vasodilation effect
Blocks/ Epidurals/ Pain Management
How are local anesthetics metabolized?
Esters - hydrolyzed by plasma cholinesterase (aka acetylcholinesterase, produced by liver and ALSO BREAKS DOWN SUCCINYLCHOLINE)
Amides - metabolized by liver
Blocks/ Epidurals/ Pain Management
What are important properties of local anesthetics?
- Amides with more rapid onset
- Site infection and acidosis slows onset
- Increased risk of toxicity with hypoxia and acidosis
- Adding bicarbonate speed onset and decreases duration of effect
Blocks/ Epidurals/ Pain Management
What are important properties of local anesthetics?
- Adding vasoconstrictors (epinephrine) slows absorption of local anesthetics
- Adding vasoconstrictor decrease bleeding
- Absorption is dose related
- Highly vascular areas with faster systemic absorption