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Flashcards in Blood Deck (66):
0

Acts as an acid base buffer for whole blood

Carbonic anhydrase

1

Total iron in the body

4-5g

2

Primary storage protein of iron in the liver

Ferritin

3

Secondary storage protein of iron

Hemosiderin

4

Transport of iron

Transferrin

5

Most numerous wbcs

Neutrophils

6

Least numerous wbcs

Basophils

7

Highly lobulated nucleus

Neutrophils

8

Bilobed nucleus, stain bright red with eosin dyr

Eosinophils

9

Bilobed/trilobed nucleus, largely densely basophilic(blue granules)

Basophils

10

Produces histamine, heparin, bradykinin, serotonin

Basophils

11

Largest wbc

Monocytes

12

Eccentrically placed nucleus

Monocyte

13

Life span of plateletd

7-10 days

14

Smallest wbc

Lymphocytes

15

Round densely stained nucleus with a pale basophilic non granular cytoplasm

Lymphocytes

16

Movement of neutrophils and macrophages

Ameboid

17

1st line of defense of the body

Tissue macrophages

18

2nd and 3rd line of defende

Neutrophils, monocytes

19

Adaptive immunity involves the formation of?

Antibodies

20

Divalent antibody

IgG

21

Most abundant antibody

IgG

22

Smallest ; secondary responses; so many

IgG

23

Primary immune response

IgM

24

Largest

IgM

25

Antibody that acts as an antigen receptor

IgD

26

Mechanism of action of antibiodies

Direct- agglutination, precipitation, neutralization, lysis; indirect- complement system

27

Complement is reponsible for

Opsonization, membrane attack complex, stimulation of inflammation

28

Complement responsible for opsonization

C3b

29

Complement that is anaphylatoxin

C3a,4a,5a

30

Complement wc is chemotactic

C5a

31

Complement wc is part of the membrane attack complex

C5b -C9

32

T helper cell: CD ___ and MHC ___

4, II

33

Cytotoxic T cells: CD ___ and MHC ___

8 and I

34

Targets virally infected cells, cancer cells, transplanted cells

Cytotoxic T cells

35

Suppresses action of helper T and cytotoxic T cells

Suppressor T cells

36

Activates helper t cells

IL 1

37

Activated cytotoxic, suppressor and memory t cells

IL 2

38

Activates B cells

IL 4,5,6

39

Antigen found in type A blood

N acetyl galactosamine

40

Antigen in type b bloodw

Galactose

41

Antigen in Rh + blood

D antigen

42

Cells responsible for graft rejection

T cells

43

Drugs used for graft rejection

Glucocorticoids, azathioprine, cyclosporine

44

Events in hemostasis

Vascular constriction, platelet plug formation, blood coagulation,

45

Mechanisms for platelet plug formation

Platelet adhesion, platelet aggregation

46

Responsible for platelet adhesion

vWF, glycoprotein 1b

47

responsible for platelet aggregation

Fibrinogen, glycoprotein IIb and IIIa

48

Converts prothrombin to thrombin

Prothrombin activator

49

Converts fibrinogen to fibrin

Thrombin

50

Important cation in blood coagulation

Ca

51

Pathway when there is trauma to vascular walls; faster and more explosive

Extrinsic

52

Pathway when there is trauma to blood cells or exposure to blood collagen from traumatized vessel walls

Intrinsic

53

The extrinsic pathway is initiated by

Tissue factor

54

Extrinsic pathway involves wc clotting factors

V, VII, X

55

thrombin causes a positive feedback by activation of wc clotting factor

v

56

Intrinsic pathway is initiated by

Factor XII and platelets

57

Clotting factors involved in intrinsic pathway

8,9,11,12

58

Clotting factors common to both intrinsic and extrinsic pathway

V,X

59

Hemophilia A is due to a deficiency in

Factor VIII

60

Hemophilia B is due to a deficiency in

IX

61

Hemophilia C is due to a deficiency in

XI

62

Hageman factor

XII

63

Calcium is factor?

IV

64

Stuart factor

X

65

Converts plasminogen to plasmin

Tissue plasminogen activator