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Physiology > Blood > Flashcards

Blood Flashcards

(66 cards)

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0
Q

Total iron in the body

A

4-5g

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1
Q

Acts as an acid base buffer for whole blood

A

Carbonic anhydrase

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2
Q

Primary storage protein of iron in the liver

A

Ferritin

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3
Q

Secondary storage protein of iron

A

Hemosiderin

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4
Q

Transport of iron

A

Transferrin

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5
Q

Most numerous wbcs

A

Neutrophils

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6
Q

Least numerous wbcs

A

Basophils

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7
Q

Highly lobulated nucleus

A

Neutrophils

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8
Q

Bilobed nucleus, stain bright red with eosin dyr

A

Eosinophils

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9
Q

Bilobed/trilobed nucleus, largely densely basophilic(blue granules)

A

Basophils

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10
Q

Produces histamine, heparin, bradykinin, serotonin

A

Basophils

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11
Q

Largest wbc

A

Monocytes

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12
Q

Eccentrically placed nucleus

A

Monocyte

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13
Q

Life span of plateletd

A

7-10 days

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14
Q

Smallest wbc

A

Lymphocytes

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15
Q

Round densely stained nucleus with a pale basophilic non granular cytoplasm

A

Lymphocytes

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16
Q

Movement of neutrophils and macrophages

A

Ameboid

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17
Q

1st line of defense of the body

A

Tissue macrophages

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18
Q

2nd and 3rd line of defende

A

Neutrophils, monocytes

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19
Q

Adaptive immunity involves the formation of?

A

Antibodies

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20
Q

Divalent antibody

A

IgG

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21
Q

Most abundant antibody

A

IgG

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22
Q

Smallest ; secondary responses; so many

A

IgG

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23
Q

Primary immune response

A

IgM

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24
Largest
IgM
25
Antibody that acts as an antigen receptor
IgD
26
Mechanism of action of antibiodies
Direct- agglutination, precipitation, neutralization, lysis; indirect- complement system
27
Complement is reponsible for
Opsonization, membrane attack complex, stimulation of inflammation
28
Complement responsible for opsonization
C3b
29
Complement that is anaphylatoxin
C3a,4a,5a
30
Complement wc is chemotactic
C5a
31
Complement wc is part of the membrane attack complex
C5b -C9
32
T helper cell: CD ___ and MHC ___
4, II
33
Cytotoxic T cells: CD ___ and MHC ___
8 and I
34
Targets virally infected cells, cancer cells, transplanted cells
Cytotoxic T cells
35
Suppresses action of helper T and cytotoxic T cells
Suppressor T cells
36
Activates helper t cells
IL 1
37
Activated cytotoxic, suppressor and memory t cells
IL 2
38
Activates B cells
IL 4,5,6
39
Antigen found in type A blood
N acetyl galactosamine
40
Antigen in type b bloodw
Galactose
41
Antigen in Rh + blood
D antigen
42
Cells responsible for graft rejection
T cells
43
Drugs used for graft rejection
Glucocorticoids, azathioprine, cyclosporine
44
Events in hemostasis
Vascular constriction, platelet plug formation, blood coagulation,
45
Mechanisms for platelet plug formation
Platelet adhesion, platelet aggregation
46
Responsible for platelet adhesion
vWF, glycoprotein 1b
47
responsible for platelet aggregation
Fibrinogen, glycoprotein IIb and IIIa
48
Converts prothrombin to thrombin
Prothrombin activator
49
Converts fibrinogen to fibrin
Thrombin
50
Important cation in blood coagulation
Ca
51
Pathway when there is trauma to vascular walls; faster and more explosive
Extrinsic
52
Pathway when there is trauma to blood cells or exposure to blood collagen from traumatized vessel walls
Intrinsic
53
The extrinsic pathway is initiated by
Tissue factor
54
Extrinsic pathway involves wc clotting factors
V, VII, X
55
thrombin causes a positive feedback by activation of wc clotting factor
v
56
Intrinsic pathway is initiated by
Factor XII and platelets
57
Clotting factors involved in intrinsic pathway
8,9,11,12
58
Clotting factors common to both intrinsic and extrinsic pathway
V,X
59
Hemophilia A is due to a deficiency in
Factor VIII
60
Hemophilia B is due to a deficiency in
IX
61
Hemophilia C is due to a deficiency in
XI
62
Hageman factor
XII
63
Calcium is factor?
IV
64
Stuart factor
X
65
Converts plasminogen to plasmin
Tissue plasminogen activator

Physiology (22 decks)

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