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Hugh's Intersystems > Blood > Flashcards

Flashcards in Blood Deck (17)
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1
Q

How many RBCs are they per litre?

A

3-5x10^12

2
Q

How often are RBCs replaced?

A

120days

2
Q

Apart from bone marrow, where else does haemopoiesis occur?

A

Liver and spleen in the first 6weeks to 7months of life

2
Q

Why can bone marrow transplants be given intravenously?

A

Because the bone marrow stroma is continuous with the systemic circulation and adhesion factors will capture infused cells

3
Q

How often are platelets replaced?

A

Every 10 days

4
Q

Which mature blood cells are myeloid in origin?

A

The granulocytes

Monocyte

Erythrocytes

Platelets

6
Q

How often are WBCs replaced?

A

Every 3-5 days

7
Q

What determines whether developing cells are released from the bone marrow?

A

Adhesion molecules

7
Q

Does a growth factor cause the same effects on all of its target cell population?

A

No, the same growth factor can have different effects depending on the developmental stage of the cell

9
Q

In which bones does most haemopoiesis occur in adults?

A

Axial skeleton: Pelvis, vertebrae, strenum and ribs

10
Q

What are the three most important haematinics?

A

Iron

Vitamin B12

Folate

11
Q

What is PICA?

A

Eating dirt and paper and similar material. Due to iron deficiency

13
Q

How much WBCs are there per litre?

A

2-6x10^9

14
Q

What are the granulocytes?

A

Neutrophil

Basophil

Eosinophil

15
Q

How many platelets are there per litre?

A

150-400x10^9

16
Q

What is Erythrocyte sedimentation rate (ESR) a measure of?

A

The height of RBCs that have settled in a tube at the end of an hour as a result of gravity

17
Q

How does inflammation effect ESR?

A

The inflammatory protein fibrogen is produced in excess by the liver and Ig is abundant. Both contribute to increased sendimentation therefore the height of RBCs in the tube is greater.