Blood and lymphoid system Flashcards Preview

Blood and Immunity > Blood and lymphoid system > Flashcards

Flashcards in Blood and lymphoid system Deck (5)
Loading flashcards...

Outline some key blood components

- RBC around 45% males, 40% females
-WBC (1%)
- Plasma 55% males, 60% females REM plasma mostly water, some protein, electrolytes, other solutes, nutrients, blood gases, regulatory substances (hormones and enzymes) and non protein N substances


Outline the appearance of different leukocytes

- Neutrophils- lobed, pinky faint granules
- Eosinophils- bilobed, red to brown granules
- Basophils (rare)- bi/tri-lobed- dominant purple granules
Granulocytes all in lobed shaped nucleus as cells are in various states of apoptosis

- Lymphocytes- large round nuclei with little bluish cytoplasm
- Monocytes- very large sausage shaped nucleus, bluish cytoplasm and no obvious granules


Functions of different blood cells

- RBC- blood- transport of O2 and CO2
- Platelets- blood- homeostasis, blood clot formation, repair injured tissue

WBC- primary defence:
Neutrophils- blood, connective tissue, spleen- phagocytose foreign substances and infected cells- before die chuck out their DNA so increasing traffic for bacteria to find theirs
- Eosinophils- Blood and most other tissues- Dampening immune response, allergic reactions/ asthma and defending against (e,g, worm)
- Basophil- blood- release vasoactive substances similar to mast cells in response to allergic reactions and asthma
- Lymphocytes- blood and most other tissues- T lymphocytes orchestrate specific immune defence, plasma cells, memory cells, cytotoxic T cells
- Monocytes- blood- circulating reserve macrophages (not main tissue-specific macrophages)


What cells are resident in tissue and not the blood- explain their appearance

Plasma cells- spokes of wheel
Macrophages- very large, oval, light or dented nucleus (may be hard to distinguish own nucleus from that of other cells die to undigested cellular material)
Mast cells - filled with granules- involved in vasodilation, weakening of desmosomes, arrestins to stop defence molecules so can leek out into tissue
But by time prepared often granules leaked out (like basophils)


Explain how leukocytes get out of blood

- We see the leukocytes (WBC) adhering to the wall- held by the arrestins- yet getting sloppier with rush of blood
- Leukocytes in transit- name for leukocytes squeezing out of blood vessels- increased with higher pressure of blood
Hence causing swelling of infected tissues