Blood Bank Flashcards
A whole blood collection that is ____ mL can be used to produce any blood products.
A whole blood collection that is ____ mL can be used to produce Red Blood Cells only.
A whole blood collection that is 400 +/-45 or 500 +/-50 mL can be used to produce any blood products.
A whole blood collection that is 300-404 mL can be used to produce Red Blood Cells only.
A 340 mL collection is considered less than optimal. Based on anticoagulant volume, whole blood should be either 450 +/- 45 mL or 500 +/- 50 mL. A packed Red Blood Cell unit prepared from this collection is known as a low-volume unit, and is defined as a unit prepared from a 300-404 mL whole blood collection when aiming for 450 mL, or 333-449 mL when aiming for a 500 mL collection. The resulting Red Blood Cell unit may be transfused, but other components such Platelets, Fresh Frozen Plasma, and Cryoprecipitate should not be prepared from these units.
Reference(s):
Roback JD, et al, eds. AABB Technical Manual 17thed. Bethesda, MD: AABB; 2011:201.
According to AABB standards, when can a pregnant woman donate blood?
According to AABB standards, pregnant females cannot donate, and are deferred until 6 weeks post-partum.
The most common cause of hemolytic transfusion-related deaths in the United States reported to the FDA is hemolysis due to _______.
The most common cause of hemolytic transfusion-related deaths in the United States reported to the FDA is hemolysis due to non-ABO antibodies.
The only FDA approved indication for extracorporeal photopheresis (ECP) is ______.
Off-label uses include _____.
The only FDA approved indication is for cutaneous T-cell lymphoma.
However, there are multiple off-label uses including
- GVHD
- heart and lung transplant rejection
- Multiple centers are investigating the use of ECP for treatment of autoimmune diseases such as Crohn’s disease.
Blood donor testing for Trypanosoma cruzi, the organism which causes Chagas disease?
One-time testing of each donor
TRALI is defined as ___ that occurs within ___ hours of transfusing blood product(s) in a patient without alternative risk factors for ALI. Patients develop non-cardiogenic ___ and have characteristic ___ on chest X-ray.
TRALI is defined as acute lung injury (ALI) that occurs within 6 hours of transfusing blood product(s) in a patient without alternative risk factors for ALI. Patients develop non-cardiogenic pulmonary edema and have characteristic bilateral lung infiltrates on chest X-ray.
The most common cause of immune mediated platelet refractoriness is ___
The most common cause of immune mediated platelet refractoriness is antibodies against HLA class I antigens. These antibodies typically form after exposure to contaminating white blood cells in blood products or after pregnancy.
If RBCs are deglycerolized with an open system they expire in 24 hours if properly stored at __oC.
Weak D testing must be performed___.
Segments only need to be saved from ___.
Apheresis platelets must contain at least___.
- If RBCs are deglycerolized with an open system they expire in 24 hours if properly stored at 1-6oC.
- Weak D testing must be performed with every donation for D-negative donors and babies born to D-negative moms.
- Segments only need to be saved from red cell-containing components.
- Apheresis platelets must contain at least 3 x 1011 platelets.
What is weak D?
What is partial D?
Weak D
- D-positive people who require an IAT to prove that they are D-positive (previously called “Du”).
- normal but significantly decreased amounts of D antigen on their RBCs
Partial D
- abnormal forms of D antigen in normal amounts on their RBCs
See more at: http://www.bbguy.org/education/glossary/index.aspx?alphabet=w&id=228#sthash.DG6zFPQT.dpuf
Which of the following poses the greatest risk of transfusion transmitted infections in the United States?
A) Babesia sp.
B) Borrelia burgdorferi
C) HIV variants
D) Influenza A virus subtype H5N1
E) Parvovirus B19
The prevalence, clinical severity, and history of transfusion-transmitted cases all put babesiosis at the highest risk of these five agents
What can be used for treating bleeding patients who are anticoagulated with direct thrombin inhibitors (e.g. dabigatran) or anti-Xa inhibitors (rivaroxaban)?
A) 4 units of Fresh Frozen Plasma (FFP)
B) 2 units of Apheresis Platelets
C) 10 units of Cryoprecipitate
D) 5000 units of Prothrombin Complex Concentrate (PCC)
E) There is no appropriate product to try in this situation.
- PCC, aPCC and recombinant activated factor VII may be useful for treating bleeding patients who are anticoagulated with the new direct thrombin inhibitors (e.g. dabigatran) or anti-Xa inhibitors (rivaroxaban).
- Currently, no specific reversal agents have been identified. Plasma does not appear to be beneficial in this situation.
- Irradiated granulocytes expire __.
- Granulocytes are stored___.
- Cryoprecipitate expires ___.
- Thawed plasma expires ___.
- Washed RBCs expire___.
- Irradiated granulocytes have the same expiration time as non-irradiated granulocytes: 24 hours.
- Granulocytes are stored at 20-24oC without agitation.
- Cryoprecipitate expires 1 year from collection date.
- Thawed plasma expires in 5 days after thawing.
- Washed RBCs expire in 24 hours.
The most common platelet crossmatch platform utilizes ___ as the endpoint which ranges from __ (negative reaction) to __ (4+). To perform a platelet crossmatch, patient ___ is added to donor platelet to assess compatibility.
The most common platelet crossmatch platform utilizes AHG-coated RBCs as the endpoint which ranges from a single button of cells (negative reaction) to a uniform lawn of cells (4+). To perform a platelet crossmatch, patient serum is added to donor platelet to assess compatibility.
What is the mortality rate with TA-GVHD?
Is HIV/AIDS a risk factor for TA-GVHD?
When do the symptoms of TA-GVHD present?
AABB requires irradiation to at least ___ to the center of the component.
The pancytopenia and marrow aplasia is the key discriminating factor between TA-GVHD and hematopoietic progenitor cell (HPC)- associated GVHD and responsible for the very high mortality rate (>90%) seen with TA-GVHD.
HIV/AIDS has not been shown to be a risk factor for TA-GVHD.
The symptoms of TA-GVHD present 8-10 days after transfusion.
AABB requires irradiation to at least 25Gy to the center of the component.
What is the most common reason for deferring blood donors?
The most common reason for deferring blood donors is an unacceptable hemoglobin.
