Blood Brain Barrier Flashcards
1
Q
What were the initial perceptions of the blood brain barrier?
A
Acid dyes were excluded from the greater part of the CNS
Thought to be because nerve cells had failed to internalise the dye
Later established there must be a barrier between the brain and the blood
2
Q
Where is the BBB?
A
Demonstrated to be at the tight junctions of the vascular endothelium in the CNS vessels by Reese and Karnovsky in 1967
