Blood Brain Barrier Flashcards Preview

Neuro Block 1-RG > Blood Brain Barrier > Flashcards

Flashcards in Blood Brain Barrier Deck (22):
1

What are the two anatomical bases for the BBB?

-tight junctions between endothelial cells of capillaries
-astrocytes mediating what is able to move into neuron

2

What is a pericyte?

a cell type found in the area of astrocyte-neuronal junctions that does not have a known function

3

What are the three proteins that form tight junctions?

-occludin
-claudin
-JAM

4

MCT-1 transporter?

monocarboxyate transporter 1

5

What does the monocarboxylate transporter 1 do?

transports lactate, pyruvate, and ketone bodies through luminal and abluminal surfaces

6

What are the two ketone bodies

beta-hydroxybutyrate
acetoacetate

7

Under what circumstances are ketone bodies used heavily in metabolism?

-infancy from mother's milk
-starvation
-hibernation
-extreme exclusively keotgenic diet

8

What population has an especially high expression of MCT1?

infants because of high lactate and ketone body metabolism (high breast milk fat content)

9

What is the function of P-glycoprotein?

efflux transporter

10

Where is P-glycoprotein found?

only on luminal side of capillary wall

11

What is transcytosis?

mechanism of breaching BBB by endocytosing on luminal side and exocytosing on abluminal side

12

What is the "trojan horse" approach to breaching the BBB?

using receptors meant for different molecules to get in via transcytosis

13

2 methods of transcytosis

-receptor mediated
-non-receptor mediated

14

What is the function of chemokines?

increase adhesion of inflammatory cells to luminal surface and increase rate of diapedesis into BBB

15

What is diapedesis?

the movement of cells either through tight junctions or through endothelial cells

16

When is the BBB established?

first few weeks after fertilization

17

What produces CSF?

the choroid plexus

18

Where is the choroid plexus located?

lateral ventricles

19

What is the primary transporter responsible for creating the osmotic gradient responsible for the creation of CSF?

NKCC transporter

20

What diuretic is used to block the NKCC transporter?

furosemide (lasix)

21

What is the glymphatic system?

pushes CSF into lymphatics to clear waste, works faster in sleep

22

How is carbonic anhydrase important for CSF production?

H+ is used in H+/Na+ antiporter to bring in Na+ from luminal side, HCO3- is moved into CSF