Blood Clotting and Immune Function Flashcards
(27 cards)
What are granulocytes
Type of white blood cell that has granules in them
Where do granulocytes mature
Bone marrow
Name the 3 granulocytes
Neutrophil, Eosinophil, Basophil
What’s the role of neutrophil, eosinophil, basophil
Neutrophil - Phagocytosis
Eosinophil - parasitic infections
Basophil - Inflammation, allergic reaction
What are the types of macrophage
Tissue and stationary macrophage
What are tissue macrophage + examples
Big increase in size in tissue
Alveolar macrophage, dendritic cells
Examples of stationary macrophage
Kupffer cell -liver
Osteoclasts
Meaning of haemostasis
Stoppage of bleeding/haemorrhage
What are the 3 components of haemostasis
Contraction of injured blood vessel
Formation of platelets plug
Clot formation
What is released by the endothelial cells/platelets when injured
Endothelin
What is exposed when injured
Collogen fibre
What attaches to the exposed collogen during formation of platelet plug
Von Willebrand’s Factor
What activates clotting factors
Lipids on the surface of platelets
Where are clotting factors produced and what do they require in particular
Liver, vitamin K
How do clotting factors normally circulate the blood
As zymogens
What forms when fibrinogen is converted to fibrin
Fibrin clot
What kind of reaction is clotting factors involved in
Cascade reaction
What is fibrinogen
Plasma protein
What converts fibrinogen into fibrin
Thrombin
What’s the zymogen of thrombin
Prothrombin
What’s haemophilia
Rare, inherited bleeding disorder where blood doesn’t clot properly - lack of clotting factors
What does haemophilia A lack and causes it
Lack of factors VIII - sex linked
What does haemophilia B lack and causes it
X linked, lack clotting factor IX
What’s the most common hereditary haemostatic disorder in humans and dogs
Von Willebrand Disease Factor VIII
