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Blood Components Flashcards

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1
Q

Components after Light Spin

LS - 2,000 RCF for 3 mins

A

Components after Light Spin

  • PRBCs
  • PRP
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2
Q

Components after Heavy Spin

5,000 RCF for 5 minutes

A

PC
PPP

If PPP is frozen - FFP

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3
Q

Components after Heavy Spin

5,000 RCF for 7 minutes

A

Cryoprecipitate

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4
Q

Transfusion Therapy

Main indication for use of RBCs
* Hemoglobin
* Hematorit

A

Hemolglobin: <6 g/dL
Hematocrit: <18%

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5
Q

Transfusion Therapy

Indication - WB Transfusion

A

Lodd of 25% of blood
Actively bleeding

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6
Q

Transfusion Therapy

Indication - PRBCs Transfusion

A

> 15% blood loss
No active bleeding, Normovolemic px.

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7
Q

Transfusion Therapy

PRBCs Hct

A

65-80% (not greater than 80%)

DOH - 55-75%

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8
Q

Prevent Febrile transfusion (FNHTRs)

A

leukocyte-reduced RBCs

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9
Q

Indication - Leukoreduced RBCs

A

Prevent:
1. FNHTRs
2. HLA Abs
3. CMV

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10
Q

Leukoreduced RBCs should retain ____% of RBCs

A

85%

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11
Q

<5 x 10^6 WBC

A

1 unit of leukoreduced RBCs and single donor platelet

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12
Q

<8.3x10^5 WBCs

A

1 unit of Leukoreduced Random platelet donor

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13
Q

Prevent TRALI

A

Washed RBCs

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14
Q

Inidication - Washed RBC

A

Inidication - Washed RBC

Transfusion hx:
* Allergic reactions
* Anaphylactic reactions
* TRALI

Remove plasma Proteins
PNH
Aplastic Anemia

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15
Q

Prevent GVHD

A

Irradiated RBCs

inactivate replication of lymphocytes

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16
Q

Indication - Irradiated RBCs

A

Indication - Irradiated RBCs
* Immunodeficient
* BM transplant
* Transfusion from immunocompetent 1st degree relative

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17
Q

Shelf life - Irradiated RBCs

A

28 days

Irradiation from collection: 14 dyas, Storage 14 days

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18
Q

cesium-137

A

commonly used to irradiated components

other: cobalt-60

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19
Q

Minimum dose of gamma irradiation

A

25GY

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20
Q

Transfusion therapy

Indication - Frozen RBCs

A
  • Storage of rare blood groups and autologous units
  • Ig-A deficient patients
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21
Q

Croprotective agent in Frozen RBCs

A

* Glycerol
* Dimethlysulfoxide

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22
Q

Glycerol

A

used in preparation of Frozen RBCs

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23
Q

Shlef Life - 10 years

A

Frozen RBCs

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24
Q

Method of Freezing RBCs - High Glycerol Method
* Reagent:
* Storage:
* Freezer:

A

Method of Freezing RBCs - High Glycerol Method
* Reagent: 40% glycerol
* Storage: -80C
* Freezer: Mechanical Freezer

Commonly used; Slow uncontrolled freezing

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25
Method of Freezing RBCs - **Low Glycerol** Method * Reagent: * Storage: * Freezer:
Method of Freezing RBCs - **Low Glycerol** Method * Reagent: **20%** * Storage: **-120C** * Freezer: **Liquid nitrogen** | Rapid; Controlled freezing
26
Deglycerolization | removal of glycerol
washing RBCs in **HYPOTONIC** solution and follwed by a **ISOTONIC** solution
27
Indication - RBC Aliqouts
**Transfusion for neonates**
28
**Shelf Life - RBC Aliqouts** * Closed System * Open System
Shelf Life - RBC Aliqouts * Closed System - **Original expiration of unit from collection** * Open System: **24 hrs**
29
Indication - **Neocyte enriched RBC**
* Thalassemia * Hemochromatosis
30
Indication - PC
Platelet count: **<20,000/ul** Active bleeding
31
NOT INDICATED to recieve Platelet concentrate from **RDP** | Random Donor Platelet
**Immune thrombocytopenia/Idiopathic Thrombocytiopenia** | ITP has antibodies against platelet due to multiple platelet transfusion
32
RDP
derived from WB centrifugation
33
RDP * 1 unit of platelets contains * pH * 1 unit increase platelets by __________
RDP * 1 unit of platelets contains: 5.5 x 10^10 * pH: >6.2 * 1 unit increase platelets by **5,000 - 10,000/uL**
34
Recipients of platelet units can recieve ________ random units of pooled platelets prior to transfusion
Legend: 4-6 units Harmening: 6-8 units Turgeon: 6-10 units | Average: 6 units
35
SDP | require more preparation time: **1-3 hrs**
derived from **Plateletpheresis**
36
SDP * 1 unit of platelets contains * pH * 1 unit increase platelets by __________
SDP * 1 unit of platelet contains **3x10^11** * pH: >6.2 * 1 unit increase platelets by **30,000-60,000**
37
Indicaton - SDP
**ITP** | should be HLA matched
38
**Refractoriness** | unresponsive to platelet transfusion
**<5,000/ul** after 1 hr post transfusion
39
Most common cause of Refractoriness
HLA immunization (ITP)
40
Shelf life - PC * Closed System * Open System
Shelf life - PC * Closed System - **5 days **with *constant agitation* * Open System - **4 hours**
41
Indication - Granulocyte
* Severe neutropenia- <350/uL * Systemic infection uncontrolled by antibiotics
42
>1.0x10^10
1 unit of granulocyte
43
Indication - Plasma and Detivatives * PT * aPTT * Fibrinogen
Indication - Plasma and Detivatives * PT - >16 sec. * aPTT - >60 sec. * Fibrinogen - <100 mg.dL
44
FFP is prepared within: * **6 hours** * **8 hrours**
FFP is prepared within: * **6 hours** - *ACD* * **8 hours** - *CPD, CP2D, CPDA1*
45
FFP is initially stored ________ , but once frozen, change to ________ position
FFP is initially stored **HORIZONTALLY** , but once frozen, change to **VERTICAL** position
46
Storage & Shelf life - FFP * -18C * -65C
Storage & Shelf life - FFP * -18C: 1 year * -65C: 7 years
47
Storage and Life span - Thawed FFP * 1-6C * 4C | FFP should be thawed **30-37C** for 30-45 mins
Storage and Life span - Thawed FFP Storage: **1C-4C** & **4C** Life span: 24 hrs | 4C storage if PF VIII is not needed
48
Storage of Delayed Testing - Thawed FFP
1C-6C | Refrigerate plasma after thawed when delayed for testing
49
Indication - FFP
Multiple Coagulation Deficiences Bleeding patients - need PFII, V, VII, IX, and X Warfarin effects
50
Can be prepared from FFP
Cryoprecipitate
51
Preparation - Cryoprecipitate from FFP
**Preparation - Cryoprecipitate from FFP** **FFP** 1. Thaw FFP - **4C** 2. Centrifuge - Hard Spin (7 minutes) 3. Leave **10-15mL** of plasma in the precipitate 4. *Freeze within 1 hr *after becomes slushy 5. Refrozen cryosupernate (-18C) **Frozen Cryoprecipitate** 1. Thaw - 37C | FFP > Thaw (4C) > HS > Cryoprecipitate > Freeze > Frozen FFP > Thaw(37C)
52
Storage & Life Span - Thawed Cryprecipitate * Storage * Life Span
Storage & Life Span - Thawed Cryprecipitated * Storage - **20C-24C** * Life Span - **6 hours** | Thawed cryoprecipitate is stored in **Room Temp** if delayed testing
53
Storage & Life Span - Pooled Cryprecipitate * Storage * Life Span
Storage & Life Span - Pooled Cryprecipitate * Storage: **20C-24C** * Life Span: **4 hours**
54
Components - Cryoprecipitate
* Fibribogen * AHF:VIII c * vWF * F XIII
55
Pooled from plasma using **Cold Ethanol Fractionation Medthod**
Factor Concentrates | Factor VIII, IX, XIII - lyophilized products/freeze dried
56
Preparation/Methods of Factor concentrates | to eleiminate viral contamination
Pasteurization Solvent and Detergent treatment Monocolonal purification UV irradiation
57
Tx: Classic hemophilia, Hemophilia A, FVIII deficient
F VIII concentrates
58
Tx: Hemophilia B or F IX defeciency
Factor IX products
59
3 forms of F IX products
Prothrombin complex F IX concentrate Recombinant factor IX
60
RBC substitute
Perfluorocarbons (PFCs)
61
# Plasma Volume expander Ringer's Lactate
Crystalloids
62
# Plasma volume expanders Colloids
Dextran (6%-10%)
63
Increased - RBC Storage Lesions
* Lactic acid * Plasma K+ * Plasma hemoglobin * Microaggregates
64
Decreased - RBC Storage Lesions
* ATP * 2,3-DPG * pH * Glucose * Viable Cells
65
Most susceptible unit to bacterial contamination
Platelets
66
Y. enterolitica | cold resistant
most common isolate in **RBC** units
67
**2nd Most common** isolate for bacterial contamination
Pseudomonas spp.

IHBB (11 decks)

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