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Week 23: Anemia > Blood Films and Cases > Flashcards

Flashcards in Blood Films and Cases Deck (14)
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1

The 4 values you really want to look at on a CBC

WBC
HGB (hemoglobin)
MCV
PLT (platelets)
Tells you about the 3 cell lines and the RBC size

2

How big should a normal red cell usually be?

About the same diameter as a lymphocyte nucleus

3

How do we clinically diagnose anemia?

If a patient's Hb is low

4

What is the main cause of a lifelong microcytic anemia?

Thalassemia

5

Basophilic stippling is found in what anemia?

Thalassemia

6

Are retics high or low in thalassemia?

High
Its a type of hemolytic anemia

7

What physical findings are common in thalassemia?

Jaundice
Splenomegaly

8

2 cardinal features of anemia of chronic disease

MCV slightly low
Retics are not increased

9

2 causes of macrocytic anemia with increased retics

Hemolysis
Bleeding

10

What do WBCs look like in a megaloblastic anemia?

Hypersegmented
From B12 deficiency or drugs

11

What is a cardinal sign of B12 deficiency

Macrocytic anemia with a very high MCV
Retics would not be increased

12

What would the cause of a non-megaloblastic anemia be if the bone marrow was
1. Normal
2. Abnormal

1. Alcohol excess, liver disease, hypothyroidism, marrow suppression
2. Failure (MDS), infiltration (acute leukemia)

13

Schistocytes + thrombocytopenia =

MAHA (microangiopathic hemolytic anemia)
Destruction of RBCs due to shearing across occluded small blood vessels
Forms schistocytes

14

2 main causes of MAHA

HUS
DIC