Bone Marrow and Hematopoiesis Flashcards Preview

Week 23: Anemia > Bone Marrow and Hematopoiesis > Flashcards

Flashcards in Bone Marrow and Hematopoiesis Deck (11)
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1

Red Marrow

Active
Crammed with dividing stem cells and precursors of mature blood cells
Only in the heads of femur, humerus, sternum, ribs, cranium, pelvis, vertebrae

2

Yellow marrow

Inactive bone marrow
Dominated by fat cells
May be reactivated (ex: extreme blood loss)

3

2 methods to examine bone marrow

Bone marrow biopsy
Fine needle aspiration

4

Bone marrow biopsy

Large bore needle
Whole section placed on slide
Visualization of architecture (bone and marrow)
General distribution of cells but not detail

5

Fine needle aspiration

Spread on slide (marrow smear)
No sectioning/detail of architecture of bone
Visualization of cellular detail

6

How much red:yellow marrow is there?

50:50

7

3 lineages from a multipotential hematopoietic stem cell

Erythroid lineage
Myeloid lineage
Lymphoid lineage

8

6 key cells in erythropoiesis

Proerythroblast
Basophilic erythroblast
Polychromatic erythroblast
Normoblasts
Reticulocytes
Mature RBCs

9

2 key cells in granulopoiesis and how to differentiate

Myelocyte stage: nucleus occupies about half of cell
Meta-myelocyte: indented nucleus

10

Megakaryocytes

Huge cells
Platelets are fragmented bits of their cytoplasm

11

Monopoiesis

Develop from monoblasts
Monocytes circulate for a couple of hours before they enter CT, attach to endothelium, and become macrophages