Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Microscopic Anatomy > blood II > Flashcards

blood II Flashcards

1
Q

where is the site of hematopoiesis

A

red bone marrow in the flat bones of the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what bones are considered the flat bones of the body?

A 
sternum
vertebrae
ribs
clavicles
bones of pelvis
bones of skull
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is the function of hematopoietic stem cell niches

A

nurture stem cells and maintain their properties

facilitate activity of stem cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where are stem cell niches found?

A

in association with spongy bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what condition can result from alterations in stem cell niches?

A

preleukemic condition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the function of yellow bone marrow?

A

store reserve energy

reserve for hematopoietic tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

describe nucleus of a blast

A

large and euchromatic
several nucleoli can be seen
large nucleo:cytoplasmic ratio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

describe the cytoplasm of a blast

A

will appear pale blue
number ribosomes present
NO granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

as erthrocytes go through differentiation, what are the 4 changes the nucleus goes through?

A

decrease in size
chromatin becomes more heterochromatic
nucleoli will disappear
extrusion of the nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

as erthrocytes go through differentiation, what are the 4 changes the cytoplasm goes through?

A

decrease in basophilia (# of polysomes decrease)

increase in acidophilia (because Hb is becoming present)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the 7 cell types (in order) of erthrocytes?

A 
blast
basophilic erythroblast
polychromatophilic erythroblast
normoblast
reticulocyte, orthochromatic erthyroblast
mature RBC
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

describe basophilic erythroblast nucleus

A

nucleoli disappeared

checkerboard appearance of chromatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

color or basophilic erythroblast cytoplasm

A

basophilic

navy blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the duration of the basophilic erythroblast stage

A

1-2 days

capable of 1-2 mitotic divisions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

describe cytoplasm of a polychromatophilic erythroblast

A

gradual shift from intense basophilia to intense acidophilia due to increase of Hb and decrease of polysomes
Hb binds anionic dye eosin
RNA of ribosome binds cationic dye methylene blue
“double staining” reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

duration of polychromatophilic erythroblast stage

A

3 days

capable of about 3-4 mitotic divisions

17
Q

describe nucleus of a normoblast

A

no longer capable of mitosis
smaller than polychromataphilic erythroblast
totally heterchromatic

18
Q

color or normoblast cytoplasm

A 
mostly pink (with hint of blue)
lots of Hb present and few ribosomes left
19
Q

describe a reticulocyte

A

extruded its nucleus but still has a few cytoplasmic ribosomes (which can be stained blue)
make up about 1% of the circulating blood

20
Q

orthochromatic erythroblast

A

lose residual RNA before they exclude nucleus (so still has it in this stage)
bright eosinophilic cytoplasm

21
Q

color of eosiniphillic stain`

A

pink

22
Q

how long does erythrocyte production take

A

8-9 days

23
Q

where is the hormone erythropoietin synthesized?

A

kidney cortex

24
Q

what is the function of erythropoietin?

A

increase rate of mitosis in developing RBCs

increase RNA synthesis in developing RBCs

25
Q

what are erythroblastic islands?

A

polychromatophilic erythroblasts clustered around reticular cells

26
Q

what is the role of erythroblastic islands

A

play trophic role in the maturation of RBCs
supply nutrients and growth factors to developing RBCs
also will phagocytose extruded normoblast nuclei

27
Q

describe how a plasma cell looks

A

basophilic cytoplasm (pink)
eccentrically placed nucleus
clock fast distribution of chromatin

28
Q

describe a megakaryocyte

A

cytoplasm becomes eosinophilic

azurophilic granules appear in cytoplasm

29
Q

new model of platelet formation

A

pseudopod formation
pseudopod elongate forming proplatelets
platelets released from ends of proplatelets
demarcation channels are membrane reservoir

30
Q

how many days to platelets circulate and where are they destroyed?

A

10 days

spleen and liver

31
Q

what are the general features of lymphocytes differentiation?

A

cell size decreases
chromatin becomes condense
nucleoli becomes less visible
lymphocyte subsets acquire distinctive cell surface receptors

32
Q

where do B cells begin and end there differentiation

A

begin in bone marrow

complete it in the lymph nodes, spleen etc

33
Q

what are monocytes

A

lysosomes

34
Q

what is a useful marker for monocyte

A

a-naphthyl acetate esterase (monocytes contain this)

35
Q

how long can a tissue macrophage function

A

1-3 months

36
Q

how long does the formation of a monocyte take

A

2-3 days

37
Q

how many days are monocytes in peripheral circulation

A

1-2 days

Microscopic Anatomy (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions