BLOOD PRESERVATIVES/ ADDITIVES/REJUVENATION/ FREEZING

Question 1

The goal of blood preservation is to provide viable and functional blood components for patients requiring blood transfusion.

[?] is a measure of in vivo RBC survival following transfusion

The FDA requires an average 24-hour post-transfusion RBC survival of more than [?].

Answer 1

RBC viability

75%

Question 2

21days
21 days
21days
35 days
42 days

Answer 2

Acid –citrate dextrose (ACD)

Citrate-phosphate-dextrose (CPD)

Citrate-phosphate double dextrose (CP2D)

Citrate phosphate adenine (CPDA-1)

CPDA-2

Question 3

The loss of RBC viability has been correlated with the [?], which is associated with various biochemical changes

Answer 3

storage lesion

Question 4

Acts as anticoagulant, chelates calcium

Answer 4

Citrate

Question 5

Provides energy or glucose to RBC;

Answer 5

Dextrose/ glucose

Question 6

Substrate of ATP

Answer 6

Dextrose/ glucose

Question 7

Lowers pH thus prevent caramelization

Answer 7

Citric acid

Question 8

Maintains pH during storage

Answer 8

Monobasic sodium phosphate

Question 9

necessary for maintenance of adequate levels of 2,3-DPG

Answer 9

Monobasic sodium phosphate

Question 10

Increase ATP levels Adenine Production of ATP (Improve RBC survival from 21 to 35 days) The most commonly used anticoagulant-preservative solution for RBC is CPDA-1.

Answer 10

Monobasic sodium phosphate