BMS09-1015 Bone Cells Flashcards
What is bone
Living hard connective tissue protecting organs
What % of bone is mineral?
75
What forms matrix?
90% type 1 collagen
5% water
5% osteopontin, osteocalcin and other non-collagenous proteins
How many bones are there?
206
What is fibrocartilage?
Dense collagen 1 fibres added to hyaline matrix
What 2 things are made of elastic cartilage?
Auricle of the ear and the larynx
What is elastic cartilage?
Elastic fibres added to hyaline matrix
2 examples of hyaline cartilage
Ribs
Trachea
How do osteoclasts eat?
Lysosomes
Proton pumps
What connects osteocytes?
Canaliculi gap junctions
What shape are osteoblasts?
Cuboidal
What do osteoblasts make?
Osteoid
Structure of GAG’s
Brush like
Matrix proteins of bone (5)
Type 1 collagen Osteocalcin Osteonectin Osteopontin Proteoglycans
Proteoglycans
Regulation of collagen fibril formation and mineralisation
Osteopontin
Attaches cells to matrix
Osteonectin
Calcium binding
Osteocalcin
Bone specific calcium binding
Does woven or lamellar bone have more cells?
Woven
Where is cortical and trabecular bone?
Cortical outside trabecular inside
