Board Flashcards
(221 cards)
Why should the dose of a medication be decreased when a patient stops smoking?
Smoking induces CYP1A2, lowering clozapine serum levels; upon cessation, levels rise.
How can liver disease impact drug levels in the body?
Liver disease affects enzyme activity, leading to potentially toxic drug levels.
What effect does kidney disease have on drug concentrations?
Kidney disease or drugs reducing renal clearance can increase serum drug levels.
What makes older adults more sensitive to psychotropics?
Factors include decreased metabolism, protein binding, muscle mass, and increased body fat concentration.
Why are inducers and inhibitors of enzymes important to know in drug therapy?
They impact drug levels which can lead to subtherapeutic or toxic levels.
What are some examples of drugs that can reduce renal clearance of lithium?
Examples include NSAIDs, thiazides, and ACE inhibitors like HCTZ.
Where is norepinephrine produced in the brain?
Norepinephrine is produced in the locus coeruleus and medullary reticular formation.
What is the role of GABA in the brain and how does it relate to anxiety?
GABA is an inhibitory NT; decreased levels can increase anxiety.
What are some risk factors associated with Autism Spectrum Disorder?
Risk factors include being male, genetic loading, and intellectual disability.
Which part of the brain is the largest and divided into lobes?
The cerebrum is the largest part of the brain, divided into lobes.
Define tolerance in relation to drugs.
Tolerance is the process of becoming less responsive to a particular drug over time.
What are the three levels of prevention in mental health?
Primary, secondary, and tertiary prevention.
What is the primary aim of primary prevention?
Decreasing the incidence of mental disorders.
Give an example of secondary prevention in mental health.
Screening programs or telephone hotlines.
What is the focus of tertiary prevention in mental health?
Decreasing disability and severity.
What are the DSM-5 criteria for ADHD in adults?
≥ 5 symptoms per category, noticeable in ≥ 2 settings, impact on functioning.
What are the common neurotransmitter dysfunctions in ADHD?
Dopamine, norepinephrine, and serotonin dysfunction.
What are the signs of stimulant abuse in ADHD?
Insomnia, tremors, elevated blood pressure, mood swings, etc.
Name a non-stimulant medication used for ADHD.
Strattera (atomoxetine).
What are some nonpharmacological management strategies for ADHD?
Behavioral therapy, psychoeducation, family therapy, etc.
Describe the primary symptoms of Borderline Personality Disorder.
Impulsivity, recurrent suicidal behavior, intense relationships, identity disturbances.
What treatment approach is recommended for Borderline Personality Disorder?
Dialectical Behavioral Therapy (DBT).
List some characteristics of Antisocial Personality Disorder.
Reckless, deceitful, lack of remorse, impulsivity, disregard for others.
What are the core symptoms of Rett Syndrome?
Loss of purposeful hand skills, stereotypic hand movements.