Bone Flashcards
1
Q
What does sclerostin do
A
Inhibits osteoblasts
BLOCKS Wnt/beta catenin pathway
DECREASES bone mass
2
Q
Where does sclerostin come from
A
osteocytes
3
Q
Transcription factors assoc w/ bone formation
A
RUNX2, beta catenin, Osx
4
Q
What do osteoblasts produce
A
RANKL, osteoprotegrin
5
Q
Receptors on osteoblasts
A
PTH
1,25 Vit D
6
Q
Receptors on osteoclasts
A
RANK
calcitonin
M-CSF
Integrin
7
Q
Inhibitors of osteoclasts
A
Calcitonin IL-10 OPG Estrogen TGF-beta Denosumab
8
Q
Organic composition of bone
A
Collagen Proteoglycans Osteocalcin Osteonectin Osteopontin
9
Q
Composition of proteoglycans
A
HA backbone
GAGs (keratin sulfate, chondroitin sulfate)
10
Q
Physis zones
A
Epiphysis Resting/Reserve Proliferative Hypertrophy (Maturation, Degenerative, Provisional calcification) Primary spongiosa (metaphysis) Secondary spongiosa
11
Q
Reserve zone of physis disorders
A
Gaucher’s
Kneist
Diastrophic dysplasia
Pseudoachondroplasia
12
Q
Proliferative zone of physis disorders
A
Achondroplasia
MHE
Gigantism
13
Q
Hypertrophic zone of physis disorders
A
SCFE Rickets Enchondromas Schmids SH1 fx
